A study of the effects of exercise on the urinary metabolome using normalisation to individual metabolic output [PDF]
, 2015 Aerobic exercise, in spite of its multi-organ benefit and potent effect on the metabolome, has yet to be investigated comprehensively via an untargeted metabolomics technology.
Anthony, Nahoum +5 more
core +2 more sources
Performance of the Roche Total Mycophenolic Acid® assay on the Cobas Integra 400®, Cobas 6000® and comparison to LC-MS/MS in liver transplant patients [PDF]
, 2011 Background: Mycophenolic acid (MPA) is an immunosuppressant for which therapeutic drug monitoring (TDM) is performed for optimal prophylaxis and avoidance of toxicity in transplant patients.
Decavele, An-Sofie +3 more
core +1 more source
Using a competitive counterflow assay to identify novel cationic substrates of OATP1B1 and OATP1B3
Frontiers in Physiology, 2022 OATP1B1 and OATP1B3 are two drug transporters that mediate the uptake of multiple endo- and xenobiotics, including many drugs, into human hepatocytes. Numerous inhibitors have been identified, and for some of them, it is not clear whether they are also ...
Regina D. Schnegelberger +3 more
doaj +1 more source
Dissociation between Cervical Mucus and Urinary Hormones during the Postpartum Return of Fertility in Breastfeeding Women [PDF]
, 2018 Identifying the return of fertility with cervical mucus observations is challenging during the postpartum period. Use of urinary measurements of estrogen and progesterone can assist in understanding the return to fertility during this period.
Blackwell, Len +4 more
core +2 more sources
Risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed [PDF]
, 2017 Peer reviewedPublisher ...
EFSA Panel on Contaminants in the Food Chain (CONTAM)
core +1 more source
Glucuronidation: driving factors and their impact on glucuronide disposition
Drug Metabolism Reviews, 2017 Glucuronidation is a well-recognized phase II metabolic pathway for a variety of chemicals including drugs and endogenous substances. Although it is usually the secondary metabolic pathway for a compound preceded by phase I hydroxylation, glucuronidation alone could serve as the dominant metabolic pathway for many compounds, including some with high ...
Guangyi, Yang +15 more
openaire +3 more sources
PharmaceuticsBackground: Glucuronidation is an essential metabolic pathway for a variety of drugs. IMM-H004 is a novel neuroprotective agent against ischemic stroke, and its glucuronide metabolite IMM-H004G exhibits similar pharmacological activity.
Jianwei Jiang +6 more
doaj +1 more source
Characterization and Quantification of Major Flavonol Glycosides in Ramps (Allium tricoccum)
Molecules, 2019 The ramp (Allium tricoccum) is a traditional plant in the eastern Appalachian Mountains. Ramps have been used in traditional medicine for their health-promoting roles in lowering blood pressure and cholesterol.
Wijdan M. Dabeek +3 more
doaj +1 more source
Identification of plasma and urinary metabolites and catabolites derived from orange juice (poly)phenols: analysis by high-performance liquid chromatography–high-resolution mass spectrometry [PDF]
, 2016 Orange juice is a rich source of (poly)phenols, in particular, the flavanones hesperetin-7-O-rutinoside and naringenin-7-O-rutinoside. Following the acute consumption of 500 mL of orange juice containing 398 μmol of (poly)phenols by 12 volunteers, 0–24 h
Ada García +10 more
core +1 more source
Advanced Science, EarlyView.This study maps the spatiotemporal distribution of hydrophobic toxicants and endogenous metabolites in the developing placenta and fetus. By integrating mass spectrometry imaging with snRNA‐seq, we identify SR‐B1 as a key transporter driving early‐gestation xenobiotic transfer and reveal a critical exposure window associated with persistent fetal ...
Yixuan Huang +10 more
wiley +1 more source