Results 61 to 70 of about 87,618 (315)
Hyodeoxycholate-6-O-glucuronide cannot be quantitated with 3 alpha-hydroxysteroid dehydrogenase
Journal of Lipid Research, 1987 The reaction of the 6-hydroxylated bile acid, hyodeoxycholic acid, and its 6-O-glucuronide conjugate with 3 alpha-hydroxysteroid dehydrogenase was examined. A standard end-point assay and determination of the initial rates of reaction showed only minimal
J M Little +3 more
doaj +1 more source
Unraveling the functional role of the orphan solute carrier, SLC22A24 in the transport of steroid conjugates through metabolomic and genome-wide association studies. [PDF]
, 2019 Variation in steroid hormone levels has wide implications for health and disease. The genes encoding the proteins involved in steroid disposition represent key determinants of interindividual variation in steroid levels and ultimately, their effects ...
Boerwinkle, Eric +13 more
core +2 more sources
British Journal of Clinical Pharmacology, EarlyView.Background and Purpose Although opioids are central to end of life (EoL) care, tissue‐level opioid exposure remains poorly understood. The objective of this study was to characterize the relationship between prescription‐derived morphine equivalent daily dose (MEDD) and measured morphine concentrations across multiple organs.
Niamh Higgins +23 more
wiley +1 more source
Unveiling Hepatic Protein Alterations in Neonatal and Infant Biliary Atresia
Clinical Pharmacology &Therapeutics, EarlyView.Pediatric populations differ from adults in drug elimination capacity. While current scaling methods account for enzyme and transporter maturation, they overlook comorbidities, such as biliary atresia (BA), a liver disease appearing within the first 2–8 weeks of life that can progress to cirrhosis.
Zubida M. Al‐Majdoub +5 more
wiley +1 more source
In vivo metabolism of ibuprofen in growing conventional pigs : a pharmacokinetic approach [PDF]
, 2019 The juvenile conventional pig has been suggested as a preclinical animal model to evaluate pharmacokinetic (PK), pharmacodynamic (PD), and safety parameters in children. However, a lot of developmental changes in pig physiology still need to be unraveled.
Croubels, Siska +3 more
core +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Human radiolabeled mass balance studies are crucial for comprehensively characterizing the absorption, distribution, metabolism, and excretion (ADME) of investigational drugs, providing essential data for drug development, regulatory evaluation, and product labeling.
Jason Boer +24 more
wiley +1 more source
Microbial phenolic metabolites are associated with better frontal lobe cognition
Food Science and Human WellnessWith increasing life expectancy, neurodegenerative diseases have become one of the leading causes of ill-health in the elderly. Preventive strategies include following healthy diets, such as the Mediterranean diet, which is particularly rich in ...
Inés Domínguez-López +9 more
doaj +1 more source
Journal of Analytical Methods in Chemistry, 2017 Icaritin is a naturally bioactive flavonoid with several significant effects. This study aimed to clarify the metabolite profiling, pharmacokinetics, and glucuronidation of icaritin in rats.
Beibei Zhang +5 more
doaj +1 more source
Bioavailability of orange juice (poly)phenols: the impact of short-term cessation of training by male endurance athletes [PDF]
, 2017 Background: Physical exercise has been reported to increase the bioavailability of citrus flavanones. Objective: To investigate the bioavailability of orange juice (OJ) (poly)phenols in endurance-trained men before and after cessation of training for 7 ...
Crozier, Alan +7 more
core +2 more sources
Drug Testing and Analysis, EarlyView.The study developed a single Abnormal Steroid Profile Score (ASPS) to improve interpretation of the Athlete Biological Passport steroid module. Using Bayesian modelling and logistic regression, biomarker patterns from laboratory and doping control data successfully discriminated between doped and clean individuals, with improved classification ...
James G. Hopker +3 more
wiley +1 more source