Results 281 to 290 of about 30,656 (311)

Ontogenesis of UDP-glucuronosyltransferase enzymes in sheep

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology, 2011
UDP glucuronosyltransferases (UGTs) are important for the metabolism of many drugs. To understand the ontogeny of these enzymes in sheep (Ovis aries), knowledge of their expression levels at different developmental stages is important. cDNA sequences of six UGTs (UGT1A1, UGT1A3, UGT1A4, UGT1A6 and UGT1A9) were cloned in sheep liver by rapid ...
Geoff Hammond, Manoja Pretheeban, Dan W. Rurak, Stelvio M. Bandiera, Wayne Riggs   +4 more
openaire   +3 more sources

Transcriptional Regulation of UDP-Glucuronosyltransferases

2009
Totowa, New ...
Xie, Wen, Mackenzie, Peter Ian, Radominska-Pandya, A   +2 more
openaire   +1 more source

Genetic polymorphisms of UDP-glucuronosyltransferases and their functional significance

Toxicology, 2002
UDP-Glucuronosyltransferase (UGT), the microsomal enzyme responsible for glucuronidation reactions, exists as a superfamily of enzymes. Genetic polymorphism has been described for 6 of the 16 functional human UGT genes characterised to date, namely UGT 1A1, 1A6, 1A7, 2B4, 2B7 and 2B15.
Ross A. McKinnon, Peter I. Mackenzie, John O. Miners   +2 more
openaire   +3 more sources

Roles of UDP-Glucuronosyltransferases in Chemical Carcinogenesi

Critical Reviews in Biochemistry and Molecular Biology, 1991
UDP-glucuronosyltransferases (UGT) play a major role in the elimination of nucleophilic metabolites of carcinogens, such as phenols and quinols of polycyclic aromatic hydrocarbons. In this way they prevent their further oxidation to electrophiles, which may react with DNA, RNA, and protein.
openaire   +2 more sources

Metabolism of Endobiotics and Xenobiotics by UDP-Glucuronosyltransferase

1997
Publisher Summary All organisms are exposed to a number of chemical compounds that are toxic were it not for metabolic mechanisms available to the organism to moderate their effects. Chemical substances may be xenobiotics, such as drugs, or compounds presented to the organism from environmental or dietary sources.
Mitchell D. Green, Christopher D. King, Thomas R. Tephly, Ziqiang Cheng, Birgit L. Coffman, Gladys R. Rios   +5 more
openaire   +3 more sources

UDP-glucuronosyltransferases

Pharmacology & Therapeutics, 1989
B, Burchell, M W, Coughtrie
openaire   +2 more sources

UDP-Glucuronosyltransferase inhibitors

European Journal of Drug Metabolism and Pharmacokinetics, 1998
Zlatina Naydenova, Konstantin Grancharov, Evgeny Golovinsky   +2 more
openaire   +2 more sources

Transcriptome analysis of Panax zingiberensis identifies genes encoding oleanolic acid glucuronosyltransferase involved in the biosynthesis of oleanane-type ginsenosides

Planta, 2018
Qingyan Tang, Geng Chen, Wan-ling Song, W. Fan, K. Wei, Si-mei He, Guang-hui Zhang, Junrong Tang, Ying Li, Yuan Lin, Sheng-chao Yang   +10 more
semanticscholar   +1 more source

The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling

Clinical Pharmacokinetics, 2018
J. Badée, S. Fowler, S. Wildt, A. Collier, S. Schmidt, N. Parrott   +5 more
semanticscholar   +1 more source

Inhibition of human UDP‐glucuronosyltransferase enzymes by lapatinib, pazopanib, regorafenib and sorafenib: Implications for hyperbilirubinemia

Biochemical Pharmacology, 2017
J. Miners, N. Chau, A. Rowland, Kushari Burns, R. Mckinnon, P. Mackenzie, G. Tucker, K. Knights, G. Kichenadasse   +8 more
semanticscholar   +1 more source