Results 291 to 300 of about 30,656 (311)

Characterisation and Regulation of UDP-Glucuronosyltransferases

1991
Many drugs, xenobiotics and endogenous compounds are metabolised via common two stage pathway, which was designated as phase 1 (oxidative metabolism) and phase II (conjugation) by Williams (1). Glucuronidation reactions catalysed by the UDP-glucuronosyltransferases (UDPGTs) is arguably the major conjugation system of phase II metabolism. The metabolism
openaire   +2 more sources

Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk

Drug metabolism reviews (Softcover ed.), 2016
D. Hu, P. Mackenzie, R. Mckinnon, R. Meech   +3 more
semanticscholar   +1 more source

Identification and characterization of naturally occurring inhibitors against UDP-glucuronosyltransferase 1A1 in Fructus Psoraleae (Bu-gu-zhi).

Toxicology and Applied Pharmacology, 2015
Xin-xin Wang, X. Lv, Shi-yang Li, J. Hou, Jing Ning, Jia-Yue Wang, Yun-feng Cao, Guangbo Ge, Bin Guo, Ling Yang   +9 more
semanticscholar   +1 more source

Simultaneous Quantification of the Abundance of Several Cytochrome P450 and Uridine 5′-Diphospho-Glucuronosyltransferase Enzymes in Human Liver Microsomes Using Multiplexed Targeted Proteomics

Drug Metabolism And Disposition, 2014
Brahim Achour, Matthew Russell, J. Barber, A. Rostami-Hodjegan   +3 more
semanticscholar   +1 more source

Relevance of UDP-glucuronosyltransferase polymorphisms for drug dosing: A quantitative systematic review.

Pharmacology and Therapeutics, 2014
J. Stingl, J. Stingl, H. Bartels, R. Viviani, M. Lehmann, J. Brockmöller   +5 more
semanticscholar   +1 more source

Transcriptional regulation of human UDP-glucuronosyltransferase genes

Drug metabolism reviews (Softcover ed.), 2014
D. Hu, R. Meech, R. Mckinnon, P. Mackenzie   +3 more
semanticscholar   +1 more source

Inhibition of human drug-metabolising cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in vitro by uremic toxins

European Journal of Clinical Pharmacology, 2014
K. J. Barnes, A. Rowland, T. Polasek, J. Miners   +3 more
semanticscholar   +1 more source

Expression of UDP‐glucuronosyltransferase 1A in bladder cancer: Association with prognosis and regulation by estrogen

Molecular Carcinogenesis, 2014
K. Izumi, Yi Li, H. Ishiguro, Yichun Zheng, Jorge Yao, G. Netto, H. Miyamoto   +6 more
semanticscholar   +1 more source

Differential induction and glycosylation of UDP-glucuronosyltransferase

Biochemical Society Transactions, 1984
Peter I. Mackenzie, Ida S. Owens
openaire   +3 more sources

DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS

Drug Metabolism And Disposition, 2004
J. A. Williams, R. Hyland, Barry Jones, Dennis A. Smith, S. Hurst, T. Goosen, Vincent C. Peterkin, Jeffrey R. Koup, Simon E. Ball   +8 more
semanticscholar   +1 more source