Results 341 to 350 of about 226,163 (382)
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Current Pharmaceutical Design, 2012
Increasing evidence suggests that abnormalities in glutamatergic transmission may be associated with psychosis risk. Genetic polymorphisms associated with schizophrenia converge on NMDA receptor signalling pathways, and transgenic animal models and human neuroimaging studies have shown the functional impact of these risk alleles.
Egerton, Alice +2 more
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Increasing evidence suggests that abnormalities in glutamatergic transmission may be associated with psychosis risk. Genetic polymorphisms associated with schizophrenia converge on NMDA receptor signalling pathways, and transgenic animal models and human neuroimaging studies have shown the functional impact of these risk alleles.
Egerton, Alice +2 more
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2002
The toxic effects of glutamate exposure on neurons were first recognized nearly half a century ago, when Lucas and Newhouse observed that subcutaneous administration of glutamate caused loss of neurons in the inner nuclear layer of the retina in both adult and neonatal mice (1). Olney extended these findings to other regions of brain, including neurons
Dennis W. Choi, B. Joy Snider
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The toxic effects of glutamate exposure on neurons were first recognized nearly half a century ago, when Lucas and Newhouse observed that subcutaneous administration of glutamate caused loss of neurons in the inner nuclear layer of the retina in both adult and neonatal mice (1). Olney extended these findings to other regions of brain, including neurons
Dennis W. Choi, B. Joy Snider
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Hippocampal glutamate receptors
Molecular and Cellular Biochemistry, 1981For years, the hippocampus has been the privileged domain of anatomists and electrophysiologists for investigating various neurobiological processes. The present review deals with recent work which shows that this structure is also well suited to study the role of glutamate as a neurotransmitter and more particularly the characteristics of glutamate ...
Gary Lynch, Michel Baudry
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Progress in Neurobiology, 2001
Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to glutamate transporter proteins present in the plasma membranes of both glial cells and neurons. The transporter proteins represent the only (significant) mechanism for removal of glutamate from the extracellular fluid and their importance for the long-term maintenance
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Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to glutamate transporter proteins present in the plasma membranes of both glial cells and neurons. The transporter proteins represent the only (significant) mechanism for removal of glutamate from the extracellular fluid and their importance for the long-term maintenance
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2012
Orexin neurons are localized in the lateral hypothalamus and regulate many functions including sleep-wake states. Substantial number of neurotransmitters and neuromodulators has been proposed to influence orexinergic system. Glutamate, as the major excitatory amino acid neurotransmitter in the hypothalamus, was shown to mediate orexin neurons in the ...
Minbay, Zehra +2 more
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Orexin neurons are localized in the lateral hypothalamus and regulate many functions including sleep-wake states. Substantial number of neurotransmitters and neuromodulators has been proposed to influence orexinergic system. Glutamate, as the major excitatory amino acid neurotransmitter in the hypothalamus, was shown to mediate orexin neurons in the ...
Minbay, Zehra +2 more
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Metabotropic glutamate receptors
Cell and Tissue Research, 2006Metabotropic glutamate receptors (mGlus) are a family of G-protein-coupled receptors activated by the neurotransmitter glutamate. Molecular cloning has revealed eight different subtypes (mGlu1-8) with distinct molecular and pharmacological properties. Multiplicity in this receptor family is further generated through alternative splicing. mGlus activate
Ferraguti F., Shigemoto R.
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Effects of molecular weight on thermal responsive property of pegylated poly-l-glutamates
Chinese Journal of Polymer Science, 2013Shusheng Zhang, Chongyi Chen, Zhibo Li
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Thermoresponsive polypeptides from pegylated poly-L-glutamates.
Biomacromolecules, 2011Chongyi Chen, Zhaohui Wang, Zhibo Li
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