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Glutamine synthetase and hepatocellular carcinoma
Clinics and Research in Hepatology and Gastroenterology, 2023Glutamine synthetase (GS) is an enzyme that converts ammonia and glutamate to glutamine using adenosine triphosphate. GS is expressed in the brain, kidney, and liver tissues under normal physiological conditions. GS is involved in abnormal lipid metabolism of the liver by catalyzing de novo synthesis of glutamine, thereby inducing liver inflammation ...
Jinghua, Jiang +3 more
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Glutamine synthetase deficiency
2020Prenatal onset malformations of the brain, seizures, necrolytic erythema of the skin, enteropathy with diarrhea, early neonatal death, and multiorgan failure or chronic encephalopathy and developmental delay, hyperammonemia, low concentration of glutamine in plasma and cerebrospinal fluid, and deficient activity of glutamine synthetase.
William L. Nyhan +3 more
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Inhibitors of Glutamine Synthetase
2002Due to the chemical inertness of the N2 molecule, the availability of metabolically accessible inorganic nitrogen sources was a key limiting factor for plant life on earth. The large scale conversion of N2 into NH3 and NO 3 - and their use as nitrogen fertilizer has been an agricultural standard for less than a century.
Guenter Donn, Helmut Köcher
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Induction of glutamine synthetase by cortisol
Biochimica et Biophysica Acta (BBA) - General Subjects, 1968Abstract A 2-fold increase in the activity of hepatic glutamine synthetase ( L -glutamate: ammonia ligase (ADP), EC 6.3.1.2) was observed following the administration of cortisol to adrenalectomized rats and this response was prevented by actinomycin D.
F. Rosen, P.N. Raina
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Glutamine synthetase deadenylylating enzyme
Biochemical and Biophysical Research Communications, 1968The glutamine synthetase of Escherichiacoli exists in various forms differing from each other by their content of covalently bound adenylyl groups (Shapiro etal., 1967;Wulff etal., 1967). The biosynthetic activity of unadenylylated glutamine synthetase is very much greater with Mg2+ as the activating cation than with Mn2+, and its γ-glutamyl ...
Bennett M. Shapiro, Earl R. Stadtman
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Regulation of glutamine synthetase
Archives of Biochemistry and Biophysics, 1966Abstract The glutamine synthetase of Escherichia coli, which is subject to cumulative feedback inhibition by eight different products of glutamine metabolism, is also regulated by repression. The enzyme is repressed by growth on media containing readily available nitrogen, such as yeast extract-peptone or high concentrations of ammonium salts.
Earl R. Stadtman +2 more
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Glutamine synthetase in the avian diencephalon
Journal of Experimental Zoology, 1973AbstractGlutamine synthetase (GS) activities are high in the nucleus rotundus of the avian diencephalon in late embryos and hatched chicks. The nucleus rotundus is known to be one component of a visual pathway in birds involving also the neural retina, the optic tectum and the cerebral ectostriatum.
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Regulation of Glutamine Synthetase Activity
EcoSal Plus, 2004Detailed studies of the glutamine synthetase (GS) in Escherichia coli and other bacteria have shown that the activity of this enzyme is regulated by at least five different mechanisms: (i) cumulative feedback inhibition by multiple end products of glutamine metabolism, (ii) interconversion between taut and relaxed ...
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The optical specificity of glutamine synthetase
Archives of Biochemistry and Biophysics, 1960The optical specificity of the glutamine synthetase isolated from dried peas has been studied. The degree of optical specificity shown by the enzyme is a function of the pH, the activating meta-lion concentration, the metal-ion species and the concentration of ammonia or hydroxylamine.
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Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2008
Glutamine plays important roles in the interorgan transport of nitrogen, carbon and energy but little is known about glutamine metabolism in the horse. In this study we determined the tissue distribution of glutamine synthetase expression in three Standardbred mares.
Malcolm Watford +5 more
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Glutamine plays important roles in the interorgan transport of nitrogen, carbon and energy but little is known about glutamine metabolism in the horse. In this study we determined the tissue distribution of glutamine synthetase expression in three Standardbred mares.
Malcolm Watford +5 more
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