対称ジエステルの選択的モノ加水分解反応の大量スケールへの発展と開環メタセシス重合による置換ポリノルボルンネン合成への応用 [PDF]
室蘭工業大学博士（工学）対称ジエステルにおける等価な２つのエステル基の片方のみを高選択的にモノ加水分解する反応は、有機合成や高分子化学において有用な中間体であるハーフエステルの合成手法として長年注目されてきた。 本研究では、まずシュウ酸の対称ジエステルを用いた高選択的かつmolという大量スケールでのモノ加水分解法を確立した。具体的には、塩基としてKOHまたはNaOHの水溶液を用い、水またはTHF/水の共溶媒系にて穏和な条件下で反応を行い、ハーフエステルを高収率・高選択性で得ることができた。塩基の種類 ...
LIN, XIAOXUE, リン, シャオシュエ
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Understanding epilepsy in IDH-mutated gliomas: towards a targeted therapy. [PDF]
Neuro Oncol, 2022 Winkler F.
europepmc +1 more source
Synthesis and evaluation of the antibacterial activity of Cu(II) and Ni(II) complexes with mixed ligands based on glycine and dicarboxylic acids [PDF]
A large number of metal complexes have the ability to inhibit bacterial growth. Cu(II) and Ni(II) complexes based on glycine (Gly), itaconic acid (Ita), and oxalic acid (Ox) were synthesized by conventional methods and evaluated for their antibacterial ...
Elizabeth Pabón-Gelves +2 more
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Radiopharmaceutical for detecting PSMA - positive metastatic colon cancer: Matched-pair comparison of 18F-BF3-Cy3-ACUPA and 68Ga-PSMA PET/MRI. [PDF]
Nucl Med Rev Cent East Eur, 2022 Aras O +4 more
europepmc +1 more source
Malic enzyme 2 as a therapeutic target for cancer: comments on 'Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate'. [PDF]
J Mol Cell Biol, 2022 Zhang Z, Du W.
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3-Methyl Glutaconic Aciduria and Elevated Plasma Growth Differentiation Factor 15 Level in an Adult with Monoallelic <i>SPG7</i> Pathogenic Variant. [PDF]
Acta MyolOlarewaju BA +7 more
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Repeatability of Semi-Quantitative and Volumetric Features from Artificial-Intelligence-Guided Lesion Segmentation on <sup>18</sup>F-DCFPyL PSMA-PET/CT Images: Results from a Test-Retest Cohort. [PDF]
TomographyIslam MZ +12 more
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A Pathogenic L2HGDH Variant Impairs Mitochondrial Targeting and Enzyme Function in L-2-Hydroxyglutaric Aciduria: Clinical and Functional Evidence from Two Affected Siblings. [PDF]
Genes (Basel)Guo Q +4 more
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