Results 11 to 20 of about 15,240 (224)

Enhancing Solubility and Dissolution Rate of Antifungal Drug Ketoconazole through Crystal Engineering

Pharmaceuticals, 2023
To improve the solubility and dissolution rate of the BCS class II drug ketoconazole, five novel solid forms in 1:1 stoichiometry were obtained upon liquid-assisted grinding, slurry, and slow evaporation methods in the presence of coformers, namely ...
Hongmei Yu, Li Zhang, Meiju Liu, Dezhi Yang, Guorong He, Baoxi Zhang, Ningbo Gong, Yang Lu, Guanhua Du   +8 more
doaj   +1 more source

Anesthetic management of multiple acyl-coenzyme A dehydrogenase deficiency in a series of surgeries under general anesthesia: a case report

JA Clinical Reports, 2021
Background Glutaric acidemia is a type of multiple acyl-coenzyme A dehydrogenase deficiency, an inborn error in fatty acid metabolism. In patients with glutaric acidemia, during the perioperative period, prolonged fasting, stress, and pain have been ...
Ryoko Owaki-Nakano, Midoriko Higashi, Kohei Iwashita, Kenji Shigematsu, Emiko Toyama, Ken Yamaura   +5 more
doaj   +1 more source

Deliquescence and crystallization of ammonium sulfate‐glutaric acid and sodium chloride‐glutaric acid particles [PDF]

Geophysical Research Letters, 2004
In the following, we report the deliquescence relative humidities (DRH) and crystallization relative humidities (CRH) of mixed inorganic‐organic particles, specifically ammonium sulfate‐glutaric acid and sodium chloride‐glutaric acid particles. Knowledge of the DRH and CRH of mixed inorganic‐organic particles is crucial for predicting the role of ...
Parsons, Matthew T., Fok, Abel, Pant, Atul, Bertram, Allan K., Mak, Jackson   +4 more
openaire   +2 more sources

Characterizations and Assays of α-Glucosidase Inhibition Activity on Gallic Acid Cocrystals: Can the Cocrystals be Defined as a New Chemical Entity During Binding with the α-Glucosidase?

Molecules, 2020
Cocrystallization with co-former (CCF) has proved to be a powerful approach to improve the solubility and even bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs).
Na Xue, Yutao Jia, Congwei Li, Binnan He, Caiqin Yang, Jing Wang   +5 more
doaj   +1 more source

Glutaric Acidemia, Pathogenesis and Nutritional Therapy

Frontiers in Nutrition, 2021
Glutaric acidemia (GA) are heterogeneous, genetic diseases that present with specific catabolic deficiencies of amino acid or fatty acid metabolism. The disorders can be divided into type I and type II by the occurrence of different types of recessive ...
Qian Li, Chunlan Yang, Lijuan Feng, Yazi Zhao, Yong Su, Hong Liu, Hongkang Men, Yan Huang, Heinrich Körner, Xinming Wang, Xinming Wang   +10 more
doaj   +1 more source

Biochemical Testing Promotes Interpretation of Variants of Uncertain Significance in Prenatal Genetic Disease Testing in Four Organic Acidurias. [PDF]

Clin Genet
This review demonstrates how amniotic fluid biochemical testing provides critical phenotypic evidence (ACMG PP4) for reclassifying variants of uncertain significance (VUS) in prenatal organic acidurias. Integrating metabolite analysis with genetic testing enhances diagnostic accuracy and enables informed clinical decisions for affected families ...
Yin K, Qi Q.
europepmc   +2 more sources

Two patients with glutaric aciduria type 3: a novel mutation and brain magnetic resonance imaging findings

The Turkish Journal of Pediatrics, 2020
Background. Glutaric Aciduria Type 3 (GA-3) is a rare metabolic disease which is inherited autosomal recessively and characterized by isolated glutaric acid excretion. To date, a limited number of cases have been reported in the literature.
Sevil Dorum, Cengiz Havalı, Özlem Görükmez, Orhan Görükmez   +3 more
doaj   +1 more source

Cloud condensation nucleus (CCN) behavior of organic aerosol particles generated by atomization of water and methanol solutions [PDF]

, 2006
Cloud condensation nucleus (CCN) experiments were carried out for malonic acid, succinic acid, oxalacetic acid, DL-malic acid, glutaric acid, DL-glutamic acid monohydrate, and adipic acid, using both water and methanol as atomization solvents, at three ...
Flagan, R. C., McFiggans, G., Rissman, T. A., Seinfeld, J. H., Surratt, J. D., Topping, D. O., Varutbangkul, V.   +6 more
core   +5 more sources

Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I [PDF]

, 2007
Glutaric acidemia type I (GA-I) is an inherited disorder of lysine and tryptophan metabolism presenting with striatal lesions anatomically and symptomatically similar to Huntington disease.
Banos, Blemings, Cathy Housman, Colon, Cornford, Daniel, Daniel, Hayashi, Ian Simpson, James P. O’Callaghan, James R. Connor, Jelena Lazovic, Juliet, Kathryn LaNoue, Keith C. Cheng, Kyllerman, Leibel, Lowry, Michael Woontner, Miller, Provencher, Rao, Russell, Russell E. Jacobs, Stephen I. Goodman, Strauss, Strauss, Tews, Vonsattel, William J. Zinnanti, Williamson   +30 more
core   +3 more sources

A rare inborn error of metabolism masquerading as meningitis

Medical Journal of Dr. D.Y. Patil University, 2016
We hereby describe a 7-month-old female baby, born to first-degree cousins, who was initially diagnosed as meningitis based on the features of seizures and dystonia with fever.
Madhumita Nandi, Sumantra Sarkar, Tapan Dhibar   +2 more
doaj   +1 more source