Results 41 to 50 of about 15,240 (224)

Formulation of itraconazole nanococrystals and evaluation of their bioavailability in dogs [PDF]

, 2014
The aim of the study is to increase the bioavailability of itraconazole (ITRA) using nanosized cocrystals prepared via wet milling of ITRA in combination with dicarboxylic acids.
Adriaensens, Peter, Carleer, Robert, De Beer, Thomas, De Smet, Lieselotte, Remon, Jean Paul, Saerens, Lien, Van Bocxlaer, Jan, Vervaet, Chris   +7 more
core   +1 more source

Membrane translocation of glutaric acid and its derivatives

Journal of Inherited Metabolic Disease, 2008
SummaryThe neurodegenerative disorder glutaric aciduria type I (GA I) is characterized by increased levels of cytotoxic metabolites such as glutaric acid (GA) and 3‐hydroxyglutaric (3OHGA). The present report summarizes recent investigations providing insights into mechanisms of intra‐ and intercellular translocation of these metabolites.
Muehlhausen, Chris, Burckhardt, Birgitta-Christina, Hagos, Yohannes, Burckhardt, Gerhard, Keyser, Britta, Lukacs, Zoltan, Ullrich, Kurt, Braulke, Thomas   +7 more
openaire   +3 more sources

Deliquescence of malonic, succinic, glutaric, and adipic acid particles [PDF]

Journal of Geophysical Research: Atmospheres, 2004
In order to understand and predict the role of organic particles in the atmosphere their deliquescence behavior must be understood. Using an optical microscope coupled to a flow cell, we investigated the deliquescence of malonic, succinic, glutaric, and adipic acid particles with sizes ranging from 2 to 40 μm.
Lipetz, Sarah R., Mak, Jackson, Parsons, Matthew T., Bertram, Allan K.   +3 more
openaire   +2 more sources

Thermal analysis, X-ray powder diffraction and electron microscopy data related with the production of 1:1 Caffeine:Glutaric Acid cocrystals

Data in Brief, 2016
The data presented in this article are related to the production of 1:1 Caffeine:Glutaric Acid cocrystals as part of the research article entitled “Green production of cocrystals using a new solvent-free approach by spray congealing” (Duarte et al., 2016)
Íris Duarte, Rita Andrade, João F. Pinto, Márcio Temtem   +3 more
doaj   +1 more source

Peptomer Linkers Enable Kinetic Control over Co‐Delivery of Multiple Chemotherapeutics

Advanced Healthcare Materials, EarlyView.
A key challenge in combinatorial chemotherapeutic drug delivery is independent control over release kinetics, especially with drugs of similar size and structure. Here, peptoid substitutions to proteolytically degradable peptides enabled the design of fast and slow‐releasing drug linkers.
Carolyn M. Watkins, Samuel L. Hallam, Mariah J. Austin, Adrianne M. Rosales   +3 more
wiley   +1 more source

Remote‐Controllable Immune‐Priming Spot Formation Via Nanocomplexed Hydrogel‐Assisted Histotripsy: Immunoasis

Advanced Materials, EarlyView.
A novel immunotherapeutic strategy combines injectable, adjuvant‐loaded hydrogels with externally controlled histotripsy to create immune‐priming sites within tumors. This approach generates millimeter‐sized immune‐activated lesions with flexible, patient‐tailored treatment scheduling, enabling precise immune activation through tumor ablation‐mediated ...
Sung Hoon Kim, Wonseok Choi, Yurim Kim, Hyeongmin Kim, Gu Won Jeong, Hyewon Park, Inchan Youn, Yoon Park, Sungmin Han, Young‐Min Kim   +9 more
wiley   +1 more source

Homogeneous vs. heterogeneous nucleation in water-dicarboxylic acid systems [PDF]

Atmospheric Chemistry and Physics, 2009
Binary heterogeneous nucleation of water-succinic/glutaric/malonic/adipic acid on nanometer-sized particles is investigated within the frame of classical heterogeneous nucleation theory. Homogeneous nucleation is also included for comparison. It is found
A. I. Hienola, H. Vehkamäki, I. Riipinen, M. Kulmala   +3 more
doaj  

Concentrations of higher dicarboxylic acids C5 – C13 in fresh snow samples collected at the High Alpine Research Station Jungfraujoch during CLACE 5 and 6 [PDF]

, 2008
Samples of freshly fallen snow were collected at the high alpine research station Jungfraujoch (Switzerland) in February and March 2006 and 2007, during the Cloud and Aerosol Characterization Experiments (CLACE) 5 and 6. In this study a new technique has
Fries, Elke, Kippenberger, Matthias, Moortgat, Geert K., Sieg, Karsten, Williams, Jonathan, Winterhalter, Richard   +5 more
core  

Organic component vapor pressures and hygroscopicities of aqueous aerosol measured by optical tweezers [PDF]

, 2014
Measurements of the hygroscopic response of aerosol and the particle-to-gas partitioning of semivolatile organic compounds are crucial for providing more accurate descriptions of the compositional and size distributions of atmospheric aerosol. Concurrent
Cai, Chen, Clegg, Simon L., Dutcher, Cari S., Ohm, Peter, Reid, Jonathan P., Stewart, David J., Zhang, Yun Hong   +6 more
core   +2 more sources

A Bioinstructive Injectable Hydrogel for Enhancing Intrinsic Regeneration through Cell Recruitment and Training

Advanced Science, EarlyView.
A bioinstructive injectable hydrogel enables sustained release of stromal cell–derived factor‐1 alpha (SDF‐1α) and stable retention of laminin through ionic and hydrophobic interactions. This dual‐signaling matrix promotes endogenous stem cell recruitment and training, supports angiogenesis, and enhances intrinsic regenerative processes in ischemic ...
Yurim Kim, Young‐Min Kim
wiley   +1 more source