Results 111 to 120 of about 17,667 (261)

Purification and Characterization of an Arene cis-Dihydrodiol Dehydrogenase Endowed with Broad Substrate Specificity toward Polycyclic Aromatic Hydrocarbon Dihydrodiols [PDF]

Applied and Environmental Microbiology 72 (2006) 4726-4734, 2009
Initial reactions involved in the bacterial degradation of polycyclic aromatic hydrocarbons (PAHs) include a ring-dihydroxylation catalyzed by a dioxygenase and a subsequent oxidation of the dihydrodiol products by a dehydrogenase. In this study, the dihydrodiol dehydrogenase from the PAH-degrading Sphingomonas strain CHY-1 has been characterized.
arxiv  

Assessment of urinary 6‐oxo‐pipecolic acid as a biomarker for ALDH7A1 deficiency

Journal of Inherited Metabolic Disease, Volume 48, Issue 1, January 2025.
Abstract ALDH7A1 deficiency is an epileptic encephalopathy whose seizures respond to treatment with supraphysiological doses of pyridoxine. It arises as a result of damaging variants in ALDH7A1, a gene in the lysine catabolism pathway. α‐Aminoadipic semialdehyde (α‐AASA) and Δ1‐piperideine‐6‐carboxylate (P6C), which accumulate because of the block in ...
Youssef Khalil, Emma Footitt, Reddy Vootukuri, Michael F. Wempe, Curtis R. Coughlin II, Spyros Batzios, Matthew P. Wilson, Viktor Kožich, Peter T. Clayton, Philippa B. Mills   +9 more
wiley   +1 more source

Structure–function relation of cytokinins determines their differential efficiency in mediating tobacco resistance against Pseudomonas syringae

Physiologia Plantarum, Volume 177, Issue 1, January/February 2025.
Abstract The classic plant growth‐promoting phytohormone cytokinin has been identified and established as a mediator of pathogen resistance in different plant species. However, the resistance effect of structurally different cytokinins appears to vary and may regulate diverse mechanisms to establish resistance.
Dominik K. Großkinsky, Eva M. Molin, Federico Bosetto, Kerstin Edelsbrunner, Michal Oravec, Kristýna Večeřová, Jan Tříska, Thomas Roitsch   +7 more
wiley   +1 more source

Substrates and mechanism of 2-hydroxyglutaryl-CoA-dehydratase from Clostridium symbiosum [PDF]

, 2009
Muconyl-CoA, 2-hydroxyadipoyl-CoA, oxalocrotonyl-CoA and butynedioyl- CoA were synthesised and characterised as substrates of the (R)-2- hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum.
Parthasarathy, Anutthaman
core   +1 more source

Glutaric Aciduria Type I Diagnosis Case with Normal Glutaryl Carnitine and Urine Organic Acid Analysis

Journal of Pediatric Research, 2018
Glutaric aciduria Type I (GA-I) is a rare inherited metabolic disease, deficiency of glutaryl-CoA dehydrogenase results in accumulation of the putatively neurotoxic metabolites glutaric and 3-hydroxyglutaric acid (GA, 3-OH-GA) in body tissues ...
Ebru Canda, Havva Yazıcı, Esra Er, Cenk Eraslan, Yasemin Atik Altınok, Hepsen Mine Serin, Sara Habif, Gül Serdaroğlu, Sema Kalkan Uçar, Hüseyin Onay, Ferda Özkınay, Mahmut Çoker   +11 more
doaj   +1 more source

Oxidative stress and cellular senescence: Roles in tumor progression and therapeutic opportunities

MedComm – Oncology, Volume 3, Issue 4, December 2024.
Cellular senescence is intrinsically related to multiple aspects of tumor development. Oxidative stress contributes to tumor development by regulating cellular senescence. Targeting cellular senescence by modulating oxidative stress can benefit tumor management.
Ping Jin, Xu‐Dong Feng, Cheng‐Shuang Huang, Jia Li, Hui Wang, Xian‐Mei Wang, Lei Li, Lan‐Qing Ma   +7 more
wiley   +1 more source

Evidence of a single origin for the most frequent mutation (R402W) causing glutaryl-CoA dehydrogenase deficiency: Identification of 3 novel polymorphisms and haplotype definition [PDF]

, 2000
Christiane Busquets, M. Josep Coll, Antònia Ribes   +2 more
openalex   +2 more sources

Treatment of glutaric aciduria type I (GA-I) via intracerebroventricular delivery of GCDH

Fundamental Research, 2022
Glutaric aciduria type I (GA-I) is an autosomal recessive genetic disorder caused by a deficiency in glutaryl-CoA dehydrogenase (GCDH). Patients who do not receive proper treatment may die from acute encephalopathic crisis.
Lu Guo, Zhikun Li, Yuhuan Li, Bin Qu, Guanyi Jiao, Chen Liang, Zongbao Lu, Xin-Ge Wang, Cheng Huang, Hongwei Du, Jianmin Liang, Qi Zhou, Wei Li   +12 more
doaj  

Increased glutamate receptor and transporter expression in the cerebral cortex and striatum of gcdh-/- mice: possible implications for the neuropathology of glutaric acidemia type I.

PLoS ONE, 2014
We determined mRNA expression of the ionotropic glutamate receptors NMDA (NR1, NR2A and NR2B subunits), AMPA (GluR2 subunit) and kainate (GluR6 subunit), as well as of the glutamate transporters GLAST and GLT1 in cerebral cortex and striatum of wild type
Valeska Lizzi Lagranha, Ursula Matte, Talita Giacomet de Carvalho, Bianca Seminotti, Carolina Coffi Pereira, David M Koeller, Michael Woontner, Stephen I Goodman, Diogo Onofre Gomes de Souza, Moacir Wajner   +9 more
doaj   +1 more source

Acute renal proximal tubule alterations during induced metabolic crises in a mouse model of glutaric aciduria type 1 [PDF]

, 2013
The metabolic disorder glutaric aciduria type 1 (GA1) is caused by deficiency of the mitochondrial glutaryl-CoA dehydrogenase (GCDH), leading to accumulation of the pathologic metabolites glutaric acid (GA) and 3-hydroxyglutaric acid (3OHGA) in blood ...
Braulke, Thomas, Koeller, David M., Lamp, Jessica, Meyer-Schwesinger, Catherine, Mühlhausen, Chris, Schweizer, Michaela, Thies, Bastian, Ullrich, Kurt   +7 more
core   +1 more source