Organic acidurias: Major gaps, new challenges, and a yet unfulfilled promise [PDF]
, 2020 Organic acidurias (OADs) comprise a biochemically defined group of inherited metabolic diseases. Increasing awareness, reliable diagnostic work-up, newborn screening programs for some OADs, optimized neonatal and intensive care, and the development of ...
Baumgartner, M.R. (Matthias) +7 more
core +1 more source
Enzymatic AND-Gate Based on Electrode-Immobilized Glucose-6-Phosphate Dehydrogenase: Towards Digital Biosensors and Biochemical Logic Systems with Low Noise [PDF]
Biosens. Bioelectron. 25, 695-701 (2009), 2009 Electrode-immobilized glucose-6-phosphate dehydrogenase is used to catalyze an enzymatic reaction which carries out the AND logic gate. This logic function is considered here in the context of biocatalytic processes utilized for the biocomputing applications for "digital" (threshold) sensing/actuation.
arxiv +1 more source
Production of glutaconic acid in recombinant Escherichia coli [PDF]
, 2010 Glutaric and glutaconic acids serve as monomers for the production of polymers. Glutaric acid (pentanedioic acid) might be used for polyester synthesis, related to the biodegradable Ecoflex available from BASF.
Djurdjevic, Ivana
core +1 more source
Glutarate regulates T cell metabolism and anti-tumour immunity [PDF]
, 2023 T cell function and fate can be influenced by several metabolites: in some cases, acting through enzymatic inhibition of α-ketoglutarate-dependent dioxygenases, in others, through post-translational modification of lysines in important targets.
Antrobus, Robin +16 more
core +1 more source
DHTKD1 Mutations Cause 2-Aminoadipic and 2-Oxoadipic Aciduria [PDF]
, 2012 Abnormalities in metabolite profiles are valuable indicators of underlying pathologic conditions at the molecular level. However, their interpretation relies on detailed knowledge of the pathways, enzymes, and genes involved.
Danhauser, Katharina +13 more
core +1 more source
Recommendations for diagnosing and managing individuals with glutaric aciduria type 1: Third revision [PDF]
, 2022 Glutaric aciduria type 1 is a rare inherited neurometabolic disorder of lysine metabolism caused by pathogenic gene variations in GCDH (cytogenic location: 19p13.13), resulting in deficiency of mitochondrial glutaryl-CoA dehydrogenase (GCDH) and ...
Ballhausen, Diana +30 more
core +1 more source
The University of California San Francisco Preoperative Diffuse Glioma MRI (UCSF-PDGM) Dataset [PDF]
Radiology: Artificial Intelligence 4.6 (2022): e220058, 2021 Here we present the University of California San Francisco Preoperative Diffuse Glioma MRI (UCSF-PDGM) dataset. The UCSF-PDGM dataset includes 500 subjects with histopathologically-proven diffuse gliomas who were imaged with a standardized 3 Tesla preoperative brain tumor MRI protocol featuring predominantly 3D imaging, as well as advanced diffusion ...
arxiv +1 more source
Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase [PDF]
J Theor Biol 240: 464-474 (2006), 2005 Integrating biological information from different sources to understand cellular processes is an important problem in systems biology. We use data from mRNA expression arrays and chemical kinetics to formulate a metabolic model relevant to K562 erythroleukemia cells. MAP kinase pathway activation alters the expression of metabolic enzymes in K562 cells.
arxiv +1 more source
The sodium-dependent di- and tricarboxylate transporter, NaCT, is not responsible for the uptake of D-, L-2-hydroxyglutarate and 3-hydroxyglutarate into neurons [PDF]
, 2006 Multi-objective evolutionary algorithms (MOEAs) have become increasingly popular as multi-objective problem solving techniques. Most studies of MOEAs are empirical. Only recently, a few theoretical results have appeared.
Katja Brauburger +2 more
core +3 more sources
Mechanistic effects of amino acids and glucose in a novel glutaric aciduria type 1 cell model. [PDF]
PLoS ONE, 2014 Acute neurological crises involving striatal degeneration induced by a deficiency of glutaryl-CoA dehydrogenase (GCDH) and the accumulation of glutaric (GA) and 3-hydroxyglutaric acid (3-OHGA) are considered to be the most striking features of glutaric ...
Xi Fu +7 more
doaj +1 more source