Results 61 to 70 of about 5,871 (233)

Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line

Medical and Veterinary Entomology, EarlyView.
Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre, Karoline dos Anjos Lima, Fernanda de Paula Pepino, Daniela Cosentino‐Gomes, Adivaldo Fonseca, Lesley Bell‐Sakyi, Georgia Correa Atella, Lucia H. Pinto‐da‐Silva   +7 more
wiley   +1 more source

Glutaric aciduria type 1 and neonatal screening: time to proceed—with caution [PDF]

, 2018
The new technology of tandem mass spectrometry is having a significant impact on the diagnostics of inborn metabolic errors. One of the most important aspects of this new technology is the possibility of recognising a whole class of disorders within a ...
Superti-Furga, Andrea
core  

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer

International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.
Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley   +1 more source

Analysis of polymorphic marker rs9384 located in the GCDH gene region associated with glutaricaciduria type 1. [PDF]

, 2016
زمینه و هدف: گلوتاریک اسید یوریای نوع 1 نوعی اختلال متابولیکی عصبی می باشد که در اثر جهش در ژن رمز کننده آنزیم گلوتاریل کوآدهیدروژناز (GCDH) ایجاد می شود.
Badr, Zahra., Jazayeri, Ali., Salehi, Zivar., Vallian-Brojeni, Sadegh.   +3 more
core  

Anaerobic Microbial Degradation of Hydrocarbons: From Enzymatic Reactions to the Environment [PDF]

, 2016
Hydrocarbons are abundant in anoxic environments and pose biochemical challenges to their anaerobic degradation by microorganisms. Within the framework of the Priority Program 1319, investigations funded by the Deutsche Forschungsgemeinschaft on the ...
Boll, Matthias, Buckel, Wolfgang, Einsle, Oliver, Ermler, Ulrich, Golding, Bernard T., Gunsalus, Robert P., Heider, Johann, Kroneck, Peter M.H., Krueger, Martin, Lueders, Tillmann, Martins, Berta M., Meckenstock, Rainer U., Musat, Florin, Rabus, Ralf, Richnow, Hans H., Schink, Bernhard, Seifert, Jana, Szaleniec, Maciej, Treude, Tina, Ullmann, G. Matthias, Vogt, Carsten, von Bergen, Martin, Wilkes, Heinz   +22 more
core   +2 more sources

Ratoon Season Rice Reduces Methane Emissions by Limiting Acetic Acid Transport to the Rhizosphere and Inhibiting Methanogens

Advanced Science, Volume 13, Issue 8, 9 February 2026.
This study finds that the interaction between ABA‐OsCIPK2‐OsSWEET1A reduces the allocation of methane producing bacteria carbon source (acetic acid) content to the rhizosphere soil of ratoon season rice, thereby reducing methane emissions. Abstract Rice paddies are a major, persistent source of atmospheric methane (CH4), emission rates depend on the ...
Jingnan Zou, Hailong Xu, Bin Qin, Chaojie Lan, Jinying Li, Bianhong Zhang, Huabin Zhang, Chunlin Guo, Hongfei Chen, Zhongming Fang, Quanzhi Zhao, Wenfei Wang, Changxun Fang, Zhixing Zhang, Wenxiong Lin   +14 more
wiley   +1 more source

Precise Similarity of Many Human Proteins to Proteins of Prokarya [PDF]

, 2007
Proteins originated in early forms of life and have long survived, because they have always been required. Some recognizably similar proteins are found in all sequence comparisons between species, no matter how distant, including prokaryotes and ...
Roy Britten
core   +2 more sources

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, Volume 13, Issue 10, 18 February 2026.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

On the enzymatic mechanism of 2-hydroxyisocaproyl-CoA dehydratase from Clostridium difficile [PDF]

, 2004
Die Gene ldhA und hadA aus Clostridium difficile (DSMZ 1296T) wurden kloniert und in Escherichia coli exprimiert. Die erhaltenen Proteine wurden gereinigt und als D-2-Hydroxyisocaproat-Dehydrogenase (LdhA) und 2-Hydroxyisocaproat-CoA-Transferase (HadA)
Buckel Wolfgang (Prof. Dr.), Kim Ji-Hoe
core   +1 more source

Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways

Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton, Nur Jury‐Garfe, Jiahui Liu, Caleb Beimfohr, Chitra Sunil, Steven Brooks, Pengyue Zhang, Sean D. McCabe, Timothy I. Richardson, Kun Huang, Cristian A. Lasagna‐Reeves, Jie Zhang, Travis S. Johnson   +12 more
wiley   +1 more source