Results 61 to 70 of about 17,667 (261)

Kinetic Model for a Threshold Filter in an Enzymatic System for Bioanalytical and Biocomputing Applications [PDF]

J. Phys. Chem. B 118, 12435-12443 (2014), 2014
A recently experimentally observed biochemical "threshold filtering" mechanism by processes catalyzed by the enzyme malate dehydrogenase is explained in terms of a model that incorporates an unusual mechanism of inhibition of this enzyme that has a reversible mechanism of action.
arxiv   +1 more source

Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase [PDF]

, 2016
With the increased incidence of tuberculosis (TB) caused by Mycobacterium tuberculosis there is an urgent need for new and better anti-tubercular drugs.
Besra, Gurdyal S., Blindauer, Claudia A., Chauhan, Smita, Dowson, Christopher G., Gehring, Kalle, Imam, Hasan T., Kozlov, Guennadi, Lloyd, Adrian J., Roper, David I., Usha, Veeraraghavan   +9 more
core   +2 more sources

Occurrence of subdural hematomas in Dutch glutaric aciduria type 1 patients [PDF]

, 2016
Patients with glutaric aciduria type 1 (GA1), a rare inherited metabolic disorder, have an increased risk for subdural hematomas (SDHs). GA1 is therefore generally included in the differential diagnosis of children presenting with SDHs.
Rijn, R.R. (Rick) van, Spronsen, F.J. van, Vester, M.E.M. (Marloes E.M.), Visser, G. (G.), Wijburg, F.A. (Frits), Williams, M. (Martine)   +5 more
core   +1 more source

A Treatable Neurometabolic Disorder: Glutaric Aciduria Type 1

Case Reports in Pediatrics, 2014
Glutaric aciduria type 1 (GA-1) is an autosomal recessive disorder of lysine, hydroxylysine, and tryptophan metabolism caused by deficiency of glutaryl-CoA dehydrogenase. It results in the accumulation of 3-hydroxyglutaric and glutaric acid.
S. Pusti, N. Das, K. Nayek, S. Biswas
doaj   +1 more source

Diagnosis and management of glutaric aciduria type I – revised recommendations [PDF]

, 2011
Glutaric aciduria type I (synonym, glutaric acidemia type I) is a rare organic aciduria. Untreated patients characteristically develop dystonia during infancy resulting in a high morbidity and mortality. The neuropathological correlate is striatal injury
A Boneh, A Cerisola, A Laich, A MacDonald, AA Basinger, AA Monavari, AAM Morris, Alberto B. Burlina, Alessandro P. Burlina, AM Krstulovic, Angels García Cazorla, AP Burlina, Avihu Boneh, AW Elster, B Wilcken, Bridget Wilcken, C Busquets, C Gitiaux, C Mellerio, C Mühlhausen, Cheryl R. Greenberg, Chris Mühlhausen, CR Greenberg, CR Greenberg, D Wert, David M. Koeller, DEM Francis, DH Chace, DH Morton, DW Seccombe, E Christensen, E Christensen, E Monbaliu, E Müller, E Neumaier-Probst, EA Crombez, Edith Müller, EL Twomey, EP Treacy, ER Naughten, Ernst Christensen, G Huner, G Rakocevic, Georg F. Hoffmann, GF Hoffmann, GF Hoffmann, I Baric, I Harting, J Brismar, J Heringer, J Rice, J Woelfle, J Zschocke, James V. Leonard, JB Hennermann, JC Haworth, JF Martinez-Lage, JH Walter, JH Walter, JK Hald, Jürgen G. Okun, KA Strauss, KA Strauss, KB Bjugstad, KG Dewey, KK Oguz, LM Hartley, M Dixon, M Kyllerman, M Kyllerman, M Köhler, M Lindner, M Lindner, M Nasser, M Rijn Van, Marinus Duran, Marjorie Dixon, MH Beauchamp, MJ Barry, MJ Thomason, MS Watson, Mårten Kyllerman, N Napolitano, NJ Brandt, NK Desai, O Bähr, OY Al-Dirbashi, P Garcia, Peter Burgard, PH Lipkin, R Forstner, RA Chalmers, RC Gallagher, RJ Pollitt, S Bijarnia, S Kölker, S Kölker, S Kölker, S Külkens, S Tortorelli, S Yannicelli, SI Goodman, SI Goodman, SK Lin, Stefan Kölker, Stephen I. Goodman, SW Sauer, TD Sanger, V Lütcherath, V Prietsch, VM McClelland, WE Smith, WJ Zinnanti, World Health Organization, Y Shigematsu, Z Fu, ZA Jamjoom   +116 more
core   +3 more sources

GC-MS Profile of Diodella sarmentosa (SW) Bacigalupo El Cabral ex Borhidi Ethanol Leaf Extract and its Total Dehydrogenase Inhibitory Potential [PDF]

arXiv, 2021
Phytochemical composition of ethanol leaf extract of Diodella sarmentosa was profiled with GC-MS and the inhibitory property of the extract against total microbial dehydrogenases were assessed. The major constituents of the extract were squalene (29.50%), Phytol (24.68%), phenol, 3-pentadecyl- (18.58%), 1-Butanol, 3-methyl- (9.09%) and n-Hexadecanoic ...
arxiv  

A cross-sectional controlled developmental study of neuropsychological functions in patients with glutaric aciduria type I [PDF]

, 2015
Background: Glutaric aciduria type I (GA-I) is an inherited metabolic disease due to deficiency of glutaryl-CoA dehydrogenase (GCDH). Cognitive functions are generally thought to be spared, but have not yet been studied in detail.
Boy, Nikolas, Burgard, Peter, Garbade, Sven F., Glahn, Esther M., Haege, Gisela, Heringer, Jana, Hoffmann, Georg F., Kölker, Stefan   +7 more
core   +1 more source

Discovery and implementation of a novel pathway for n-butanol production via 2-oxoglutarate [PDF]

, 2019
Background One of the European Union directives indicates that 10% of all fuels must be bio-synthesized by 2020. In this regard, biobutanolnatively produced by clostridial strainsposes as a promising alternative biofuel.
Ferreira, Ana Sofia Araújo, Liu, Filipe Alexandre Wang, Pereira, R., Rocha, Isabel, Vilaça, P.   +4 more
core   +4 more sources

Collaborative learning of images and geometrics for predicting isocitrate dehydrogenase status of glioma [PDF]

arXiv, 2022
The isocitrate dehydrogenase (IDH) gene mutation status is an important biomarker for glioma patients. The gold standard of IDH mutation detection requires tumour tissue obtained via invasive approaches and is usually expensive. Recent advancement in radiogenomics provides a non-invasive approach for predicting IDH mutation based on MRI.
arxiv  

Alterations of the mitochondrial proteome caused by the absence of mitochondrial DNA: A proteomic view [PDF]

Electrophoresis 27 (04/2006) 1574-83, 2006
The proper functioning of mitochondria requires that both the mitochondrial and the nuclear genome are functional. To investigate the importance of the mitochondrial genome, which encodes only 13 subunits of the respiratory complexes, the mitochondrial rRNAs and a few tRNAs, we performed a comparative study on the 143B cell line and on its Rho-0 ...
arxiv   +1 more source