Results 81 to 90 of about 17,667 (261)

Cardioprotective potential of simvastatin in the hyperhomocysteinemic rat heart

Journal of Advanced Pharmaceutical Technology & Research, 2012
The present study investigated the probable role of simvastatin, 3-hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase inhibitor, in abrogated cardioprotection in hyperhomocysteinemic (Hhcy) rat hearts.
Ankur Rohilla, M U Khan, Razia Khanam
doaj   +1 more source

Predicting isocitrate dehydrogenase mutation status in glioma using structural brain networks and graph neural networks [PDF]

arXiv, 2021
Glioma is a common malignant brain tumor with distinct survival among patients. The isocitrate dehydrogenase (IDH) gene mutation provides critical diagnostic and prognostic value for glioma. It is of crucial significance to non-invasively predict IDH mutation based on pre-treatment MRI.
arxiv  

Effects of HMG CoA reductase (HMGCR) deficiency on skeletal muscle development

The FEBS Journal, EarlyView.
Three skeletal muscle diseases are linked to HMGCR, a key enzyme in cholesterol synthesis. These diseases include a muscular dystrophy associated with pathogenic variants in the HMGCR gene, statin‐associated myopathy, and autoimmune anti‐HMGCR myopathy.
Mekala Gunasekaran, Hannah R. Littel, Natalya M. Wells, Johnnie Turner, Gloriana Campos, Sree Venigalla, Elicia A. Estrella, Partha S. Ghosh, Audrey L. Daugherty, Seth A. Stafki, Louis M. Kunkel, A. Reghan Foley, Sandra Donkervoort, Carsten G. Bönnemann, Laura Toledo‐Bravo de Laguna, Andres Nascimento, Daniel Natera‐de Benito, Isabelle Draper, Christine C. Bruels, Christina A. Pacak, Peter B. Kang   +20 more
wiley   +1 more source

A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells. [PDF]

, 2019
Microbial metabolites are an emerging class of mediators influencing CD4+ T-cell function. To advance the understanding of direct causal microbial factors contributing to Crohn's disease, we screened 139 predicted Crohn's disease-associated microbial ...
Borneman, James, Braun, Jonathan, Bushman, Frederic, Casero, David, Chang, Yu-Ling, Harre, Nicholas, Humphries, Romney, Huttenhower, Curtis, Lewis, James, McGovern, Dermot PB, Miller, Shelley, Rossetti, Maura, Salzman, Nita, Sartor, R Balfour, Simpson, Kenneth W, Stappenbeck, Thaddeus, Sunga, Gemalene, Vlamakis, Hera, Wu, Gary, Xavier, Ramnik   +19 more
core   +1 more source

Enzymatic AND Logic Gates Operated Under Conditions Characteristic of Biomedical Applications [PDF]

J. Phys. Chem. B 114, 12166-12174 (2010), 2010
Experimental and theoretical analyses of the lactate dehydrogenase and glutathione reductase based enzymatic AND logic gates in which the enzymes and their substrates serve as logic inputs are performed. These two systems are examples of the novel, previously unexplored, class of biochemical logic gates that illustrate potential biomedical applications
arxiv   +1 more source

Remodeling of the terpenoid metabolism during prolonged phosphate depletion in the marine diatom Phaeodactylum tricornutum

Journal of Phycology, EarlyView.
Abstract Terpenoids are a diverse class of naturally occurring organic compounds, which derive from five‐carbon isoprene units and play crucial roles in physiology, ecological interactions such as defense mechanisms, or adaptation to environmental stresses.
Florian Pruckner, Luca Morelli, Payal Patwari, Michele Fabris   +3 more
wiley   +1 more source

Electrochemical Characterization of Escherichia coli Adaptive Response Protein AidB [PDF]

, 2012
When exposed to known DNA-damaging alkylating agents, Escherichia coli cells increase production of four DNA repair enzymes: Ada, AlkA, AlkB, and AidB. The role of three enzymes (Ada, AlkA, and AlkB) in repairing DNA lesions has been well characterized ...
Becker, Bowles, Byron, Catherine Drennan, Chohan, Cintyu Wong, Clark, Delaney, Demple, Evensen, Falnes, Falnes, Fink, Frerman, Frick, Ghisla, Hamill, He, Husain, Johnson, Karran, Kim, Landini, Landini, Lenn, Leys, Maier, Marco Jost, Massey, Massey, Massey, Michael Hamill, Mulrooney, Nicholas Bene, Pace, Rippa, Roberts, Roberts, Rohankhedkar, Saenger, Samson, Sean Elliott, Sedgwick, Sedgwick, Sedgwick, Stankovich, Stiehler, Swanson, Toogood, Toogood, Trewick, Vetter, Volkert, Volkert   +53 more
core   +2 more sources

Biochemical and molecular features of Chinese patients with glutaric acidemia type 1 detected through newborn screening

Orphanet Journal of Rare Diseases, 2021
Background Glutaric acidemia type 1 (GA1) is a treatable disorder affecting cerebral organic acid metabolism caused by a defective glutaryl-CoA dehydrogenase (GCDH) gene.
Yiming Lin, Wenjun Wang, Chunmei Lin, Zhenzhu Zheng, Qingliu Fu, Weilin Peng, Dongmei Chen   +6 more
doaj   +1 more source

Bioinformatic Scaling of Allosteric Interactions in Biomedical Isozymes [PDF]

, 2015
Allosteric (long-range) interactions can be surprisingly strong in proteins of biomedical interest. Here we use bioinformatic scaling to connect prior results on nonsteroidal anti-inflammatory drugs to promising new drugs that inhibit cancer cell metabolism.
arxiv   +1 more source

Allopolyploidization events and immense paleogenome reshuffling underlying the diversification of plants and secondary metabolites in Oleaceae

Journal of Systematics and Evolution, Volume 63, Issue 2, Page 208-228, March 2025.
In this study, we revealed the frequent allopolyploidization events and immense paleogenome reshuffling during the diversification of plants in Oleaceae. At the same time, we explored the effects of these ancient evolutionary events on the synthesis of specific secondary metabolites and environmental adaptability of extant plants from Oleaceae ...
Jiaqi Wang, Yue Ding, Yinfeng Li, Xintong Gao, Xiangming Kong, Feng Long, Yishan Feng, Yan Zhang, Yu Li, Zijian Yu, Tianyu Lei, Li Wang, Xiu‐Qing Li, Jinpeng Wang   +13 more
wiley   +1 more source