Results 261 to 270 of about 21,521,606 (315)

Enzymology of Cytosolic Glutathione S- Transferases

1994
Publisher Summary The glutathione S-transferases (GSTs) catalyze a range of reactions of glutathione (GSH) with hydrophobic electrophiles. Their most established role is the glutathione conjugation of electrophiles, which would otherwise cause toxic reactions with macromolecules.
B, Ketterer, L G, Christodoulides
openaire   +2 more sources

Enzymology of Microsomal Glutathione S-Transferase

1994
Publisher Summary The study of the microsomal glutathione transferase regarding molecular properties, substrate specificity, kinetic behavior, and activation mechanisms has advanced considerably over the past few years. Polyhalogenated hydrocarbons that form toxic and carcinogenic glutathione conjugates need to be characterized with the purified ...
C, Andersson, E, Mosialou, R, Weinander, R, Morgenstern   +3 more
openaire   +2 more sources

Trialkyl phosphorothioates and glutathione S-transferases

Chemico-Biological Interactions, 1985
Using a rat liver cytosol source of enzyme trialkyl phosphorothioates have been shown to be substrates of glutathione S-transferases. Using OSS-trimethyl phosphorodithioate (OSS-Me(O] and OOS-trimethyl phosphorothioate (OOS-Me(O] the methyl transferred to the sulphydryl of glutathione is that attached to phosphorus via an oxygen atom.
W N, Aldridge, H, Grasdalen, K, Aarstad, B W, Street, T, Norkov   +4 more
openaire   +2 more sources

Glutathione-S-Transferases

1995
Glutathione S-transferases (GSTs) are a group of phase II detoxification enzymes of wide tissue distribution. They are classified into three groups, alpha, mu, and pi, on the basis of their chromosomal location, isoelectric point, and immunoreactivity.
openaire   +1 more source

Binding of acrylamide with glutathione-S-transferases

Chemico-Biological Interactions, 1980
Introduct ion GST, a family of cytosolic enzymes, plays an important role in cellular biotransformation and elimination of toxic electrophiles by glutathione conjugation and subsequent excretion as mereapturic acid [1,2]. GST bind a broad range of substrate and non~substrate ligands and subsequently function both as catalytic proteins for cellular ...
R, Dixit, H, Mukhtar, P K, Seth, C R, Murti   +3 more
openaire   +2 more sources

Glutathione S‐transferase in human brain

Neuropathology and Applied Neurobiology, 1990
The glutathione S‐transferases are a complex group of multifunctional enzymes which may detoxify a wide range of toxic substances including drugs and carcinogens. Different isoenzymes vary in substrate specificity, tissue distribution and level of expression during development.
P J, Carder, R, Hume, A A, Fryer, R C, Strange, J, Lauder, J E, Bell   +5 more
openaire   +2 more sources

Induction of glutathione S-transferase by prostaglandins

Mechanisms of Ageing and Development, 2000
Exposure of cells to a wide variety of chemoprotective compounds confers resistance to a broad set of carcinogens. For a subset of the chemoprotective compounds, protection is generated by an increase in the abundance of protective enzymes such as glutathione S-transferases (GSTs). We have recently developed a cell culture system that potently responds
openaire   +2 more sources

Assays for differentiation of glutathione S-transferases.

Methods in Enzymology, 1981
W. Habig, W. Jakoby
semanticscholar   +1 more source

THE FUNCTIONS AND REGULATION OF GLUTATHIONE S-TRANSFERASES IN PLANTS.

Annual Review of Plant Physiology and Plant Molecular Biology, 1996
K. Marrs
semanticscholar   +1 more source

Glutathione S-transferases.

Biochemical Society Transactions, 1990
Timothy J. Mantle, Fiona M. McCusker, Michael F. Phillips, Sinead J. Boyce   +3 more
semanticscholar   +1 more source