Results 161 to 170 of about 2,626,240 (311)

Safety and Effect of 12‐Month Ecopipam Treatment in Pediatric Patients with Tourette Syndrome

open access: yesMovement Disorders Clinical Practice, EarlyView.
Abstract Background Tourette syndrome (TS) is a chronic neurodevelopmental tic disorder with a considerable quality of life (QOL) burden. Objectives The goal was to determine the long‐term safety, tolerability, and clinical effects of ecopipam, a first‐in‐class dopamine D1 receptor antagonist, for TS.
Donald L. Gilbert   +7 more
wiley   +1 more source

Xanomeline‐Trospium Chloride (Cobenfy): A New Era in Managing Schizophrenia—Comparative Effectiveness and Economic Challenges

open access: yesMedicine Advances, EarlyView.
Xanomeline‐trospium chloride (cobenfy) is a muscarinic agonist used to treat hallucinations and psychotic illnesses such as Alzheimer's and Schizophrenia. It has been constructed for patients who are unable to tolerate dopamine‐targeting therapies and a comparison is drawn against other similar drugs with variables like cost, mechanism of action ...
Jawairya Muhammad Hussain   +4 more
wiley   +1 more source

Irreversible thermal denaturation of human carbonic anhydrase [PDF]

open access: yes
Carbonic Anhydrase (CA; carbonate hydro-lyase, EC 4.2.1.1)), a zinc containing enzyme, catalyzes reversible hydration of carbon dioxide. This metalloenzyme is found in animals, photosynthesizing organisms, and in some nonphotosynthetic bacteria. Thermal
امانی, مجتبی   +4 more
core  

Vitreoscilla sp. hemoglobin (VHb) Expression in Heterologous Hosts: Some Aspects of Their Biotechnological Application [PDF]

open access: yesarXiv, 2019
It is worth mentioning that the high output of different physiological responses under the expression of vgb, may have a considerable effect on the enzyme productivity, dairy industry, heavy metal uptake, biodegradation of different organic pollutants and other applications.
arxiv  

Yerba Mate (Ilex paraguariensis St. Hill.) Tea May Have Cardiometabolic Beneficial Effects in Healthy and At‐Risk Subjects: A Randomized, Controlled, Blind, Crossover Trial in Nonhabitual Consumers

open access: yesMolecular Nutrition &Food Research, EarlyView.
Yerba mate intake shows cardiometabolic beneficial effects decreasing blood pressure, blood lipids, inflammatory biomarkers and body fat in healthy and hypercholesterolemic non‐habitual consumers. ABSTRACT Yerba mate has been reported to have antihypertensive, hypocholesterolemic, antidiabetic, or antiobesity properties.
Laura Bravo   +4 more
wiley   +1 more source

A Study on Proteolytic Enzyme Activity in the Erythrocytes of Diabetic Patients [PDF]

open access: yes, 2011
The present study demonstrates the possibility of increased proteolytic activities in diabetic individuals. Proteolytic activity was measured by the amount of amino group released by the erythrocyte lysate of the diabetic individual using phenylhydrazine
Bhat, Gopalakrishna P, BS, Varashree
core  

Beta cells to brain cells: The pivotal role of insulin and glucose metabolism in Alzheimer's disease

open access: yesNeuroprotection, EarlyView.
Common metabolic, histochemical, and molecular pathologies: Type 2 diabetes and dementia. Abstract The risk factors and neuropathologies of cognitive decline and the onset and progression of dementia‐related disorders were, until recently, obtuse. A critical predisposing factor to Alzheimer's disease (AD) that has emerged is glucose dysmetabolism.
Stanley S. Schwartz   +3 more
wiley   +1 more source

Genetic and environmental contributions to the associations between midlife personality and late‐life metabolic health

open access: yesObesity, EarlyView.
Abstract Objective Personality traits such as conscientiousness and emotional stability are consistently linked with better metabolic health, but there is limited evidence on the etiology of these associations and their robustness across the life‐span. Methods Therefore, we estimated phenotypic, genetic, and unique environmental associations of traits ...
Colin D. Freilich   +8 more
wiley   +1 more source

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