Results 271 to 280 of about 163,140 (347)

Metabolic Profiling of the EmDia Cohort by LC‐MS Reveals Empagliflozin‐Intake Associated Regulation of 1,5‐anhydroglucitol and Urate

open access: yesPROTEOMICS, EarlyView.
ABSTRACT The EmDia trial, designed to study the effects of the sodium glucose cotransporter‐2 (SGLT2) inhibitor empagliflozin on cardiovascular comorbidities in type 2 diabetes mellitus (T2DM) patients, has been investigated for short‐term metabolic alterations by a limited set of clinical assays. To expand on this data, we report on the development of
Fabian Schmitt   +7 more
wiley   +1 more source

A Combined Modeling Approach to Predict the Effect of Gastric Emptying Delay on the Pharmacokinetics of Small Molecules

open access: yesCPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Dulaglutide, a long‐acting glucagon‐like peptide‐1 (GLP‐1) receptor agonist, is approved for improving glycemic control and reducing cardiovascular risks in patients with type 2 diabetes mellitus (T2DM). This research investigates the effect of dulaglutide on gastric emptying and its impact on the pharmacokinetics (PK) of orally administered ...
Maria M. Posada   +9 more
wiley   +1 more source

Stimuli‐responsive systems: A focus on controlled drug delivery for posterior segment ocular disease

open access: yesResponsive Materials, EarlyView.
This review highlights recent advances in stimuli‐responsive drug delivery for posterior segment diseases, focusing on mechanisms and potential. It also explores mechanically interlocked molecules and bioorthogonal reactions as novel approaches. Challenges and future perspectives are discussed, aiming to bridge the gap between research and clinical ...
Chengzhi Zhang   +11 more
wiley   +1 more source

eVLP‐Mediated Cas9 Delivery for Preventing IBMIR in Islet Transplantation

open access: yesSmall, EarlyView.
Engineered virus‐like particles (eVLPs) are used to deliver Cas9 nuclease to knock out tissue factor (TF) and plasminogen activator inhibitor‐1 (PAI‐1) genes in pancreatic islets. The edited islets maintained viability and function, while reducing instant blood‐mediated inflammatory reaction (IBMIR) markers and improving glycemic control in diabetic ...
Manju Shrestha   +6 more
wiley   +1 more source

Emerging Biomedical Engineering Therapies for Infected Diabetic Foot Ulcers: Toward Antibacterial Functionalization and Pathology‐Responsive Regulation

open access: yesSmall Science, EarlyView.
Infected diabetic foot ulcer endangers patients with high amputation, disability, mortality risks, and heavy medical burdens. This review analyzes its pathogenic factors, the limitations of current treatments, the breakthroughs of responsive antimicrobial biomaterials, and the challenge of multifunctional biomaterial innovations for further developing ...
Yaqi Yao   +8 more
wiley   +1 more source

Starch digestion and physiochemical properties of a newly developed rice variety with low glycemic index. [PDF]

open access: yesFood Chem X
Liao C   +8 more
europepmc   +1 more source

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