Results 281 to 290 of about 163,140 (347)

Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction

open access: yesAging Cell, EarlyView.
In this study, we demonstrated that metabolic responses to a daily‐fed caloric restriction (CR) protocol remain robust in mice that cannot engage in canonical ketogenesis. This surprising finding is due to mice physiologically adapting to the daily bouts of fasting during CR by downregulating ketone production. ABSTRACT Caloric restriction (CR) extends
Chung‐Yang Yeh   +13 more
wiley   +1 more source

Small Extracellular Vesicles From Human Amniotic Membrane Mesenchymal Stem Cells Rejuvenate Senescent β Cells and Cure Age‐Related Diabetes in Mice

open access: yesAging Cell, EarlyView.
hAMSC‐sEVs rejuvenate β cells and improve glycaemic control via the miR‐21‐5p/IL‐6RA/STAT3/MCU axis, restoring mitochondrial Ca2+ homeostasis and insulin secretion in aged T2DM mice. ABSTRACT Targeting senescent pancreatic β‐cells represents a promising therapeutic avenue for age‐related diabetes; however, current anti‐senescence strategies often ...
Lei Xiao   +8 more
wiley   +1 more source

Development of Whole-Grain Rice Lines Exhibiting Low and Intermediate Glycemic Index with Decreased Amylose Content. [PDF]

open access: yesFoods
Chaichoompu E   +10 more
europepmc   +1 more source

Low testosterone levels in men at age 31 associates with future risk of prediabetes and type 2 diabetes: A birth cohort study

open access: yesAndrology, EarlyView.
Abstract Objective We aimed to investigate the association of a low serum testosterone concentration with the risk of abnormal glucose metabolism (i.e., prediabetes and type 2 diabetes) in men at a 15‐year follow‐up. Study population and methods In a population birth cohort, men with low testosterone (testosterone < 12.1 nmol/L, n = 136) and normal ...
Tuomisto A   +7 more
wiley   +1 more source

Healthy Aging Men Do Not Suffer From Relevant Limitations of Their Reproductive Functions

open access: yesAndrology, EarlyView.
Abstract Background While metabolic disorders are well‐established contributors to testosterone decline and erectile dysfunction (ED), little is known about the natural progression of reproductive parameters in healthy aging men. Objectives This study aimed to evaluate longitudinal changes in reproductive parameters and sought to determine the ...
Simone Bier   +8 more
wiley   +1 more source

Diabetes Mellitus is a Risk Factor for Hepatic Encephalopathy Following Transjugular Intrahepatic Portosystemic Shunt

open access: yesAlimentary Pharmacology &Therapeutics, EarlyView.
Diabetes mellitus independently increases the risk of hepatic encephalopathy following TIPS placement in patients with cirrhosis. These findings emphasize the need for careful risk assessment in patients with cirrhosis and portal hypertension complications undergoing TIPS.
Michelle Spaan   +16 more
wiley   +1 more source

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