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Subcutaneous insulin: pharmacokinetic variability and glycemic variability
Diabetes & Metabolism, 2005The therapeutic goal in insulin-treated diabetic patients is to maintain on the long-term a tight glucose control (HbA1, < 6.5-7% or less) through an insulin regimen which "mimic" the physiological insulin profile: a basal insulin secretion to maintain glucose homeostasis and an acute post-prandial secretion in response to meal intake.
J.P. Sauvanet, B. Guerci
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Influence of Glycemic Variables on Hemoglobin ALC
Endocrine Practice, 2007To assess the influences of a wide variety of glucose variables on hemoglobin A1c (A1C).The Diabetes Control and Complications Trial database, restricted to volunteers whose 7-point daily capillary glucose profiles were complete in >or=80% of quarterly collections and who were in the study for >or=4 years, was used for analysis.
F John, Service, Peter C, O'Brien
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Diabetes Care, 2008
Diabetes is characterized by glycemic disorders that include both sustained chronic hyperglycemia and acute glucose fluctuations. There is now cogent evidence for the deleterious effects of sustained chronic hyperglycemia that results in excessive protein glycation and generation of oxidative stress. The role of glucose variability from peaks to nadirs
Louis Monnier, Claude Colette
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Diabetes is characterized by glycemic disorders that include both sustained chronic hyperglycemia and acute glucose fluctuations. There is now cogent evidence for the deleterious effects of sustained chronic hyperglycemia that results in excessive protein glycation and generation of oxidative stress. The role of glucose variability from peaks to nadirs
Louis Monnier, Claude Colette
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Current concepts and clinical importance of glycemic variability
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 2021Evolving evidence indicate that variations in blood glucose levels are likely to be an important factor in developing diabetic complications. Monitoring glucose fluctuations in patients remains as a therapeutic challenge and more evidence needs to be created in order to bring GV into limelight.
Ramya Ravi +3 more
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Glycemic risk factors of diabetic vascular complications: the role of glycemic variability
Diabetes/Metabolism Research and Reviews, 2009AbstractAchieving adequate targets relatively to all risk factors is considered a standard of care for patients with diabetes mellitus. To date, current guidelines underline the importance of the ‘glucose triad’ (post‐prandial glucose, fasting plasma glucose and glycated haemoglobin) as the three glycemic factors that should be controlled in diabetes ...
Giovanni Ghirlanda +2 more
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Clinical Interpretation of Indices of Quality of Glycemic Control and Glycemic Variability
Postgraduate Medicine, 2011The practicing physician is faced with the task of interpreting>2 dozen indices of quality of glycemic control and glycemic variability. It would be desirable to have reference data from relevant patient populations (eg, patients with the same type of diabetes, duration of diabetes, therapeutic regimen, or glycated hemoglobin [HbA1c] levels).
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Glycemic variability in the development of cardiovascular complications in diabetes
Diabetes/Metabolism Research and Reviews, 2018SummaryDiabetes mellitus represents a major risk factor for the development of coronary artery disease and other vascular complications. Glycated haemoglobin, fructosamine, and fasting blood glucose levels are partial parameters to exhaustively describe patient dysglycemic status.
Annunziata Nusca +7 more
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