Results 191 to 200 of about 667,395 (258)

Artificial Intelligence‐Guided Phenotypic Drug Repurposing Against Streptococcus pneumoniae

Advanced Science, EarlyView.
Integrated artificial intelligence (AI) ensembles identify highly potent repurposed drugs against Streptococcus pneumoniae. Prospective virtual screening of 6747 drugs uncovers nine active candidates, including thiostrepton. This drug exhibits low picomolar potency and bypasses established resistance in multidrug‐resistant strains, demonstrating an ...
Joshua S. Fitch, Muhammad D. Ariadi, Min Jung Kwun, Leonie Howells, Saiveth Hernandez‐Hernandez, Nicholas J. Croucher, Pedro J. Ballester   +6 more
wiley   +1 more source

Valorization of seaweed residue and agricultural side streams for molded biocomposite production: sequential RSM optimization of formulation and hot pressing. [PDF]

RSC Adv
Thi-Tuyet Hoang N, Thi-Kim Tran A, Nguyen DD.   +2 more
europepmc   +1 more source

Structural Control Over Bicontinuous Emulsions from Solvent‐Transfer Induced Phase Separation Through Nanoparticle Loading

Advanced Science, EarlyView.
The nanoparticle loading enables effective control over the liquid domain size in bicontinuous interfacially jammed emulsion gels (bijels) produced through solvent‐transfer induced phase separation (STrIPS). The relationship between the nanoparticle loading and domain size profiles in STrIPS bijels is resolved through confocal microscopy and explained ...
Jesse M. Steenhoff, Martin F. Haase
wiley   +1 more source

Role of Glycerol-3-Phosphate Dehydrogenase in the Development, Pathogenicity, and Glycerol Biosynthesis of <i>Aspergillus flavus</i>. [PDF]

J Fungi (Basel)
Zhang L, Zhao J, Lin H, Wu S, Wu F, Ning H, Wang X, Yuan J, Yang Y.   +8 more
europepmc   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Microbial oil production by Yarrowia lipolytica strains using glycerol as carbon source. [PDF]

Braz J Microbiol
Coelho EDG, Palladino F, Teixeira EAA, Oliveira FLC, Pasa VMD, Rosa LH, Rosa CA.   +6 more
europepmc   +1 more source

F‐Type Pyocin Versus Phage λ Tail: Conserved Hub, Divergent Fibers

Advanced Science, EarlyView.
Near‐atomic cryo‐EM structures of a Gram‐negative F‐type pyocin reveal a conserved tail tip architecture shared with bacteriophage λ together with a previously unrecognized side‐fiber attachment mode. These findings provide new insight into tailocin assembly and host recognition and establish a structural framework for engineering precision ...
Zhiwei Gu, Yufan Xie, Lanxin Wang, Luyan Ma, Xiaofei Ge, Jiawei Wang   +5 more
wiley   +1 more source

Optimized microwave pretreatment and ultrasound-assisted deep eutectic solvent extraction for efficient valorization of Citrus paradisi peel bioactives. [PDF]

Bioresour Bioprocess
Zumar S, Imtiaz F, Almehizia AA, Assiri AA, Sajid A, Manzoor Q, Saeed ST.   +6 more
europepmc   +1 more source

Genome‐Wide and Multi‐Omics Analysis Identified DNA‐Interacting Circular RNA circFOXK2 as MLL1 Regulator for Histone H3K4 Methylation in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Circular RNA circFOXK2 is frequently upregulated in pancreatic ductal adenocarcinoma to promote tumor heterogeneity, growth, and metastasis. Through circRNA‐DNA interaction at different genomic locations, circFOXK2 removes the PPIE inhibitory effects on MLL1 for gene‐activating H3K4 methylation of the oncogenes.
Chi Hin Wong, Jessica Jazmin Peña‐Paladines, Sum Yin Valerie Leung, Ka‐Fai To, Kenneth Siu Ho Chok, Yangchao Chen   +5 more
wiley   +1 more source

<i>Mycoplasma mycoides</i> subsp. <i>capri</i> encodes multiple pathways for hydrogen peroxide production. [PDF]

iScience
Chandran S, Gonzalez-Juarbe N, Assad-Garcia N, Yimthin T, Démoulins T, Zhang J, Alperovich N, Chuang RY, Falquet L, Blanchard A, Sirand-Pugnet P, Lartigue C, Jores J, Vashee S.   +13 more
europepmc   +1 more source