Results 41 to 50 of about 153,624 (265)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Peroxisome population control by phosphoinositide signaling at the endoplasmic reticulum‐plasma membrane interface

Traffic : the International Journal of Intracellular Transport, 2023
Phosphoinositides are lipid signaling molecules acting at the interface of membranes and the cytosol to regulate membrane trafficking, lipid transport and responses to extracellular stimuli. Peroxisomes are multicopy organelles that are highly responsive
Barbara Knoblach, R. A. Rachubinski
semanticscholar   +1 more source

Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan, John R. Mills, Paulina Vargas, Naveen K. Paramasivan, Connie E. Lesnick, Eati Basal, Surendra Dasari, James P. Fryer, Shannon R. Hinson, Joseph Laporta, Amy Espinal, Dennis Fitzgerald, Carolina Garcia, Anna E. Morenkova, Paola Pergami, Anna Shah, Andrew Knight, Reghann LaFrance Corey, Vanda A. Lennon, Anastasia Zekeridou, Sean J. Pittock, Divyanshu Dubey, Andrew McKeon   +22 more
wiley   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

GABA transporter function, oligomerization state, and anchoring: correlates with subcellularly resolved FRET [PDF]

, 2009
The mouse γ-aminobutyric acid (GABA) transporter mGAT1 was expressed in neuroblastoma 2a cells. 19 mGAT1 designs incorporating fluorescent proteins were functionally characterized by [^3H]GABA uptake in assays that responded to several experimental ...
Abramoff, Bal, Bal, Bartholomäus, Bauman, Bjerggaard, Blackman, Boudanova, Boyd, Brückner, Chen, Chiu, Chiu, Cole, Corry, Corry, Deken, Doherty, Drenan, Elangovan, Farhan, Farhan, Farhan, Farhan, Feige, Fraser J. Moss, Gauthier, Geiser, Gordon, Guastella, Harris, Hastrup, Henry A. Lester, Hess, Holton, Hu, Hung, Imoukhuede, Jares-Erijman, Jia Hu, Joanna L. Jankowsky, Just, Kanner, Kanner, Kerschensteiner, Khakh, Kilic, Kimberly Scott, Korkhov, Kuryatov, Lakowicz, Lakowicz, Lester, Lester, Li, Lin, Loder, Loo, Madsen, Mager, Manley, Mazei-Robison, McHugh, Melikian, Michael W. Quick, Miranda, Miranda, Morel, Munro, Nashmi, Nashmi, Ormö, P.I. Imoukhuede, Quick, Raicu, Raicu, Ramamoorthy, Reiterer, Reith, Riven, Rizzo, Roux, Rudnick, Rudnick, Sallette, Schmid, Scholze, Sekar, Sheng, Son, Soragna, Sorkina, Spudich, Tadross, Taunton, Tokunaga, Torres, Torres, Wallrabe, Wang, Whitworth, Xia, Yamashita, Zacharias, Zahniser, Zhang   +105 more
core   +3 more sources

Tailoring the Properties of Functional Materials With N‐Oxides

Advanced Functional Materials, EarlyView.
The properties of materials bearing N‐oxide groups are often dominated by the polar N+─O− bond. It provides hydrophilicity, selective ion‐binding, electric conductivity, or antifouling properties. Many of the underlying mechanisms have only recently been discovered, and the interest in N‐oxide materials is rapidly growing.
Timo Friedrich, Michelle Kobus, Shirin Mesgarha, Erica Moretto, Laurens Grosche, Wolfgang Maison   +5 more
wiley   +1 more source

Structure of the novel membrane-coating material in proton-secreting epithelial cells and identification as an H+ATPase. [PDF]

, 1987
Specialized proton-secreting cells known collectively as mitochondria-rich cells are found in a variety of transporting epithelia, including the kidney collecting duct (intercalated cells) and toad and turtle urinary bladders.
Brown, D, Gluck, S, Hartwig, J
core  

Involvement of the leaf-specific multidrug and toxic compound extrusion (MATE) transporter Nt-JAT2 in vacuolar sequestration of nicotine in Nicotiana tabacum [PDF]

, 2014
Alkaloids play a key role in higher plant defense against pathogens and herbivores. Following its biosynthesis in root tissues, nicotine, the major alkaloid of Nicotiana species, is translocated via xylem transport toward the accumulation sites, leaf ...
Goossens, Alain, Hayashida, Minaho, Ito, Shingo, Minami, Shota, Morita, Masahiko, Moriyama, Yoshinori, Moriyasu, Masataka, Omote, Hiroshi, Shitan, Nobukazu, Sugiyama, Akifumi, Takanashi, Kojiro, Yazaki, Kazufumi   +11 more
core   +4 more sources

Plasma Membrane-Located Purine Nucleotide Transport Proteins Are Key Components for Host Exploitation by Microsporidian Intracellular Parasites

PLoS Pathogens, 2014
Microsporidia are obligate intracellular parasites of most animal groups including humans, but despite their significant economic and medical importance there are major gaps in our understanding of how they exploit infected host cells.
E. Heinz, Christian Hacker, P. Dean, J. Mifsud, A. V. Goldberg, T. Williams, S. Nakjang, A. Gregory, R. Hirt, J. Lucocq, Edmund R. S. Kunji, T. Embley   +11 more
semanticscholar   +1 more source

Peptide Sequencing With Single Acid Resolution Using a Sub‐Nanometer Diameter Pore

Advanced Functional Materials, EarlyView.
To sequence a single molecule of Aβ1−42–sodium dodecyl sulfate (SDS), the aggregate is forced through a sub‐nanopore 0.4 nm in diameter spanning a 4.0 nm thick membrane. The figure is a visual molecular dynamics (VMD) snapshot depicting the translocation of Aβ1−42–SDS through the pore; only the peptide, the SDS, the Na+ (yellow/green) and Cl− (cyan ...
Apurba Paul, Archith Rayabharam, Lisa Almonte, Eveline Rigo, Joshy Joseph, Ashutosh Kumar, Zhuxin Dong, Narayana Aluru, Gregory Timp   +8 more
wiley   +1 more source