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ACS Chemical Neuroscience, 2018
Alzheimer's disease is a progressive neurodegenerative disorder that mainly affects the elderly. Soluble β-amyloid oligomer, which can induce neurotoxicity, is generally regarded as the main neurotoxin in Alzheimer's disease. Here we report that eckmaxol,
Jialing Wang +14 more
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Alzheimer's disease is a progressive neurodegenerative disorder that mainly affects the elderly. Soluble β-amyloid oligomer, which can induce neurotoxicity, is generally regarded as the main neurotoxin in Alzheimer's disease. Here we report that eckmaxol,
Jialing Wang +14 more
semanticscholar +1 more source
Nuclear Glycogen and Glycogen Synthase Kinase 3
Biochemical and Biophysical Research Communications, 1998Glycogen is the principal storage form of glucose in animal cells. It accumulates in electron-dense cytoplasmic granules and is synthesized by glycogen synthase (GS), the rate-limiting enzyme of glycogen deposition. Glycogen synthase kinase-3 (GSK-3) is a protein kinase that phosphorylates GS.
John A. Hanover +3 more
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Glycogen and glycogen synthase from pig leucocytes
International Journal of Biochemistry, 1979Abstract 1. 1. Pig polymorphonuclears and lymphocytes show a lower glycogen content than human leucocytes. 2. 2. The glycogen synthase activity from pig leucocytes has the same value as that from human leucocytes. 3. 3. Two forms of glycogen synthase interconvertible by phosphorylation-dephosphorylation reactions are present in pig ...
F. Pegueroles, R. Cusso
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Localization of Glycogen Synthase in Brain
Journal of Neurochemistry, 1988AbstractAntisera against glycogen synthase from canine brain were prepared and used for investigation of the localization of the enzyme in the brain. Antisera cross‐reacted only with the 88‐kilodalton protein that is the subunit of brain glycogen synthase.
Nobuhiro Inoue +3 more
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Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1989
Several polycations were tested for their abilities to inhibit the activity of glycogen synthase kinase 3 (GSK-3). L-Polylysine was the most powerful inhibitor of GSK-3 with half-maximal inhibition of glycogen synthase phosphorylation occurring at approx. 100 nM.
Mohammed G. Hegazy +3 more
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Several polycations were tested for their abilities to inhibit the activity of glycogen synthase kinase 3 (GSK-3). L-Polylysine was the most powerful inhibitor of GSK-3 with half-maximal inhibition of glycogen synthase phosphorylation occurring at approx. 100 nM.
Mohammed G. Hegazy +3 more
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On the activities of glycogen phosphorylase and glycogen synthase in the liver of the rat
Biochimica et Biophysica Acta (BBA) - General Subjects, 1978A procedure was developed for determination of glycogen synthase and phosphorylase activities in liver after various in vivo physiological treatments. Liver samples were obtained from anaesthetised rats by freeze-clamping in situ. Other procedures were shown to stimulate the activity of phosphorylase and depress the activity of glycogen in the liver ...
J.McD. Armstrong, Julie D. Newman
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Diabetes, 1972
The present status of the molecular nature of the enzyme glycogen synthase from rabbit skeletal muscle is reviewed. It is shown that per 90,000 Dalton subunit there are six phosphorylatable sites and six sulfhydryl groups. No pyridoxal phosphate is present.
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The present status of the molecular nature of the enzyme glycogen synthase from rabbit skeletal muscle is reviewed. It is shown that per 90,000 Dalton subunit there are six phosphorylatable sites and six sulfhydryl groups. No pyridoxal phosphate is present.
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The Journal of Nutrition, 1984
Rats were fasted 24, 48 or 72 hours to determine the effect of several days without food on glycogen synthase and synthase phosphatase activity in heart. The basal percentage of synthase I decreased gradually from approximately 20% in fed animals to approximately 6% in rats starved for 72 hours. Glycogen increased progressively from 4.6 mg/g wet weight
Frank Q. Nuttall, Mary C. Gannon
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Rats were fasted 24, 48 or 72 hours to determine the effect of several days without food on glycogen synthase and synthase phosphatase activity in heart. The basal percentage of synthase I decreased gradually from approximately 20% in fed animals to approximately 6% in rats starved for 72 hours. Glycogen increased progressively from 4.6 mg/g wet weight
Frank Q. Nuttall, Mary C. Gannon
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2003
The chapter provides a short summary of the structure, substrate specificity, functions, and regulation of glycogen synthase kinase 3 protein. Glycogen synthase kinase 3 (GSK3) is a protein that phosphorylates and inhibits glycogen synthase, the enzyme that catalyzes the transfer of glucose from UDPG to glycogen.
Cohen, Philip, Frame, Sheelagh
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The chapter provides a short summary of the structure, substrate specificity, functions, and regulation of glycogen synthase kinase 3 protein. Glycogen synthase kinase 3 (GSK3) is a protein that phosphorylates and inhibits glycogen synthase, the enzyme that catalyzes the transfer of glucose from UDPG to glycogen.
Cohen, Philip, Frame, Sheelagh
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Glycogen Synthase and Glycogen Synthase Kinases
1981Publisher Summary This chapter focuses on properties and other biochemical and physiological processes related to glycogen synthase and glycogen synthase kinases. The reversible covalent modification of proteins appears to be one of the fundamental mechanisms that have evolved to regulate the inherent properties of enzyme molecules.
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