Results 171 to 180 of about 27,148 (247)

Identification of luteinizing hormone-releasing factor and alpha-subunit of glycoprotein hormones in human pancreatic islets

Life Sciences, 1980
Abstract Using an immunoperoxidase technique, staining of human pancreatic islets was observed with antisera to luteinizing hormone-releasing factor (LRF) and to the glycoprotein hormones hCG, LH and the alpha-subunit. Treatment of fixed tissue sections with protease inhibitors or heat did not affect the staining indicating that the positive results ...
M, Seppälä, T, Wahlström
openaire   +3 more sources

Production of alpha-subunit of glycoprotein hormones by pituitary somatotroph adenomas in vitro

Acta Endocrinologica, 1993
Somatotroph adenomas of the pituitary secrete growth hormone in excess and are associated with acromegaly. Morphologically, they can be separated into two entities, densely and sparsely granulated variants. It has been shown that a number of somatotroph adenomas produce α-subunit of glycoprotein hormones; however, it is not clear whether α-subunit ...
G, Kontogeorgos, S L, Asa, K, Kovacs, H S, Smyth, W, Singer   +4 more
openaire   +3 more sources

Simultaneous production of the alpha-subunit of glycoprotein hormones and other hormones in pituitary adenomas

Pathology - Research and Practice, 1988
The immunohistological classification of 97 pituitary adenomas revealed in 34 cases alpha-subunit (a-su) positive cells in the tumor tissue. In 15 cases a-su was the only hormone found, in 11 cases the beta-subunits of the glycoprotein hormones could also be detected (10 cases with LH/FSH and 1 case with TSH).
G. Jautzke
openaire   +3 more sources

Glycoprotein hormone α-subunit in pituitary adenomas

Trends in Endocrinology & Metabolism, 1992
Elevated serum glycoprotein hormone alpha-subunit (alpha-subunit) levels are seen in about one of six patients bearing pituitary adenomas. This finding has particular clinical significance in patients with nonfunctioning pituitary adenomas. Moreover, the measurement of alpha-subunit along with the calculation of the molar ratio between alpha-subunit ...
P. Beck-Peccoz, L. Persani, G. Faglia
openaire   +2 more sources

Regulation of glycoprotein hormone alpha-subunit gene expression.

Recent progress in hormone research, 1999
The appropriate, regulated expression of the glycoprotein hormone subunit genes is required to enable the biosynthesis of luteinizing hormone, follicle-stimulating hormone, thyroid-stimulating hormone, and chorionic gonadotropin. We have focused our attention on mechanisms mediating regulated transcription of the common alpha-subunit gene.
R A, Maurer, K E, Kim, W E, Schoderbek, M S, Roberson, D J, Glenn   +4 more
openaire   +2 more sources

Serum glycoprotein hormone alpha subunit levels in patients with cancer

Cancer, 1979
The serum glycoprotein hormone alpha subunit concentration was measured in 957 nonpregnant patients with benign disorders and 683 patients with unselected malignancies. Postmenopausal women had significantly higher alpha levels than premenopausal women or men.
G D, Braunstein, A B, Forsythe, J L, Rasor, M B, Van Scoy-Mosher, R W, Thompson, M E, Wade   +5 more
openaire   +2 more sources

Evidence for two folding domains in glycoprotein hormone alpha-subunits

Endocrinology, 1994
We reconstituted ovine (o) LH alpha from its amino- and carboxyl-terminal fragments obtained as follows. oLH alpha was nicked at Arg46-Ser47 with Arg-C protease. Nicked oLH alpha disulfide bonds were broken by sulfitolysis, and its N-terminal peptide and C-terminal glycopeptide were separated by Sephacryl S-200 chromatography. Both fragments were mixed,
Bousfield, George R., Ward, Darrell N.
openaire   +3 more sources

HeLa cells secrete α subunit of glycoprotein tropic hormones

Nature, 1976
THE HeLa line, derived from a carcinoma of the cervix, was the first continuous human tissue culture line to be established in vitro1, and has been one of the primary sources for the study of human cell biology. Although such studies have documented the biosynthesis of certain intra-cellular and membrane proteins2–4, there has been little specific ...
J M, Lieblich, B D, Weintraub, S W, Rosen, J Y, Chou, J C, Robinson   +4 more
openaire   +2 more sources

Comparison of glycoprotein hormone α‐subunits of laboratory animals

Molecular Reproduction and Development, 2002
AbstractThe common α‐subunit of glycoprotein hormones (CGα) is a core protein shared by follicle‐stimulating hormone (FSH), luteinizing hormone (LH), and thyroid‐stimulating hormone (TSH). In order to obtain a molecular basis for an efficient superovulation technique applicable to a wide range of animal species and to discuss the phylogenetic aspect ...
Osamu, Suzuki, Keiji, Mochida, Yoshie, Yamamoto, Yoko, Noguchi, Kaoru, Takano, Junichiro, Matsuda, Astuo, Ogura   +6 more
openaire   +2 more sources

Alpha Subunit of Glycoprotein Hormone: Presence in Peripheral Serum after LHRH

European Journal of Clinical Investigation, 1975
Abstract. A method is described for the selective measurement of human luteinizing hormone (hLH) and α subunit. The assays employ highly purified tracers of hLH and of subunit of human chorionic gonadotropin (hCGα) and a “mixed population” of antibody: Population I (directed against determinants on β subunit of hCG) and Population II (directed against
R, Benveniste, L A, Frohman, J, Bell, I, Spitz, D, Rabinowitz   +4 more
openaire   +2 more sources