Results 181 to 190 of about 27,148 (247)

THYROID HORMONE, OESTROGEN, AND GLUCOCORTICOID EFFECTS ON TWO DIFFERENT PITUITARY GLYCOPROTEIN HORMONE ALPHA SUBUNIT POOLS

Clinical Endocrinology, 1978
SUMMARYSeven hypothyroid women (six postmenopausal and one premenopausal) were treated with 200 or 300 μg of levo‐T4 daily in order to suppress the secretion of TSH and its alpha and beta subunits. After such therapy, serum TSH and beta subunit of TSH (TSH‐β) levels were usually not detectable. Serum alpha decreased from a mean value of 4.5 ± 0.8 ng/ml
I A, Kourides, B D, Weintraub, R N, Re, E C, Ridgway, F, Maloof   +4 more
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Molecular Cloning of the Rhesus Glycoprotein Hormone α-Subunit Gene

DNA and Cell Biology, 1991
A rhesus monkey genomic library was screened with a cDNA for the glycoprotein hormone alpha-subunit. Genomic clones hybridizing with exon-specific probes were selected and the DNA sequences were determined for 1.6 kb of 5'-flanking DNA, all four exons, the second and third introns, all exon-intron junctions, and 357 bp of 3'-flanking DNA.
T G, Golos, M, Durning, J M, Fisher
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Efficient preparation of glycoprotein hormones lacking an α-subunit oligosaccharide

Biochemical and Biophysical Research Communications, 2003
The oligosaccharide on alpha-subunit loop 2 (alpha 2) is needed for full glycoprotein hormone efficacy. Efforts to prepare glycoprotein hormone antagonists usually involve removing the alpha 2 oligosaccharide and are hampered by its requirement for efficient heterodimer secretion from mammalian cells.
Yongna, Xing, William R, Moyle
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Secretion of Glycoprotein Hormoneα-Subunit by Pituitary Tumors*

The Journal of Clinical Endocrinology & Metabolism, 1987
Serum glycoprotein hormone alpha-subunit levels were determined in 165 patients with pituitary adenomas. Elevated serum alpha-subunit levels were found in 17 patients (acromegaly, 5 of 58; prolactinoma, 6 of 56; nonfunctioning adenoma, 5 of 32; and ACTH-producing adenoma, 1 of 19), most of whom had normal serum TSH and gonadotropin levels.
M, Ishibashi, T, Yamaji, F, Takaku, A, Teramoto, T, Fukushima   +4 more
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Tilapia glycoprotein hormone α subunit: cDNA cloning and hypothalamic regulation

Molecular and Cellular Endocrinology, 2001
The cDNA encoding the glycoprotein alpha (GPalpha) subunit of tilapia (Oreochromis mossambicus) was partially cloned using RACE-polymerase chain reaction (PCR) technique. The amplified cDNA was found to be 583 bases long, and to consist of a portion of the signal peptide, the full sequence encoding the mature peptide (94 amino acids) and the 3 ...
Gur, G, Rosenfeld, H, Melamed, P, Meiri, I, Elizur, A, Yaron, Z   +5 more
openaire   +3 more sources

Dopaminergic inhibition of glycoprotein hormone α-subunit in normal subjects

Metabolism, 1991
The pituitary glycoprotein hormones thyrotropin (TSH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) consist of two noncovalently linked subunits, alpha and beta. In addition to producing intact hormone, the pituitary releases free alpha-subunit, which is stimulated by gonadotropin-releasing hormone (GnRH) and thyrotropin-releasing ...
S, Boesgaard, C, Hagen, A, Nyboe Andersen, T, Agner   +3 more
openaire   +2 more sources

Glycoprotein hormone alpha-subunit production in somatotroph adenomas with and without Gs alpha mutations

Journal of Clinical Endocrinology & Metabolism, 1992
Activating mutations of the Gs alpha subunit have been identified in a subset of somatotroph adenomas. The mutant form of the Gs alpha subunit causes persistent activation of adenylyl cyclase and consequently results in high intracellular levels of cAMP. Because cAMP is known to stimulate the synthesis of the glycoprotein hormone (GPH) alpha-subunit as
P E, Harris, J M, Alexander, H A, Bikkal, D W, Hsu, E T, Hedley-Whyte, A, Klibanski, J L, Jameson   +6 more
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The synthesis of the glycoprotein hormone α subunit by human breast carcinomas

European Journal of Cancer (1965), 1979
The glycoprotein hormone α subunit content of 58 primary breast carcinomas was studied using an antiserum prepared against hCG α subunit. α Subunit was detected in 44% of tumour cytosols and 26% of supernatants from short-term tumour culture using a radioimmunoassay and in 23% of tumours examined by an immunoperoxidase method. In the cytosols examined,
Cove, D H, Smith, S C, Walker, R, Howell, A   +3 more
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The amino acid sequence of the rabbit glycoprotein hormone alpha subunit

Journal of Protein Chemistry, 1984
The amino acid sequence of the alpha subunit of rabbit (lagomorph) lutropin (lLH) has been determined. Overlapping peptides from trypsin and chymotrypsin digestions were isolated by reverse-phase high-pressure liquid chromatography (HPLC). Sequencing was by the dansyl-Edman procedure.
Stephan D. Glenn, Hyun S. Nahm, Darrell N. Ward   +2 more
openaire   +1 more source

Regulation of glycoprotein hormone free alpha-subunit secretion and intracellular alpha-subunit content in primary pituitary cells

Endocrinology, 1994
The effects and interactions of GnRH, TRH, a cAMP analog, a protein kinase-C (PKC) activator, a calcium ionophore, and a calcium channel blocker on pituitary glycoprotein hormone free alpha-subunit secretion and intracellular free alpha-subunit content were investigated.
J G, Holdstock, J M, Burrin
openaire   +3 more sources