Results 191 to 200 of about 27,148 (247)

[Free alpha-subunit glycoprotein hormones: physiological and pathological data].

Journal of steroid biochemistry, 1990
The glycoprotein hormone alpha-subunit is secreted as a free molecule as well as a molecule combined to a glycoprotein hormone beta-subunit. In human subjects, plasma levels of the free alpha-subunit were measured by means of a specific radioimmunoassay. Plasma concentrations were high during the neonatal period, then decreased to a nadir at the age of
M, Roger, N, Lahlou, B, Couzinet, J L, Chaussain, R, Scholler   +4 more
openaire   +1 more source

Immunohistochemical detection of glycoprotein hormone alpha subunit in somatoprolactinic and pure somatotroph adenomas

Journal of Endocrinological Investigation, 1998
Glycoprotein hormone alpha subunit (alpha SU) is expressed in nearly all thyreotroph adenomas and most gonadotrophinomas, but is less well documented in plurisecreting adenomas. We therefore examined the immunohistochemical (IHC) expression of alpha SU in a generally accepted model of plurisecreting adenomas (somatoprolactinic type) by comparison to a ...
M C, Vantyghem, C, Cortet, C, Bauters, M H, Gevaert, D, Dewailly, J, Lefebvre, M, Mazzucca   +6 more
openaire   +2 more sources

[Glycoprotein hormone alpha-subunit secretion in non-functioning pituitary adenomas].

Orvosi hetilap, 1997
The aim of the present study was to investigate the prevalence of elevated free glycoprotein hormone alpha-subunit in different pituitary adenomas, to establish the diagnostic value of the basal and stimulated free alpha-subunit secretion in non-functioning adenomas.
M, Góth, I, Szabolcs, S, Czirják, E, Hubina, L, Kovács, O, Dohán, G, Szilágyi   +6 more
openaire   +1 more source

[Glycoprotein hormone alpha subunit as a marker of pituitary adenoma].

Polski tygodnik lekarski (Warsaw, Poland : 1960), 1990
Blood serum FSH, LH, prolactin and testosterone as well as urinary excretion of 17KS and 17-OHCS were determined in 8 patients with chromophobe pituitary adenomas treated by transphenoidal microsurgical removal or craniotomy with or without subsequent telecobalt therapy.
R, Waśko, M, Gembicki, J, Kosowicz
openaire   +1 more source

Activation of the glycoprotein hormone α-subunit gene promoter in thyrotropes

Molecular and Cellular Endocrinology, 1998
Pituitary expression of the glycoprotein hormone alpha-subunit gene localizes to thyrotropes and gonadotropes. Factors that activate the alpha-subunit promoter exclusively in thyrotropes have not been described. In the current studies, alpha-subunit promoter activity was compared in alphaTSH thyrotropic and alphaT3 gonadotropic cells.
V D, Sarapura, H L, Strouth, W M, Wood, D F, Gordon, E C, Ridgway   +4 more
openaire   +2 more sources

Production of the α-subunit of glycoprotein hormones by pituitary adenomas

Pathology - Research and Practice, 1988
Positive immunoreactions with alpha-subunit antibodies were present in 43% of biopsy samples obtained from 147 subsequently operated pituitary adenomas representing all major endocrine types (57 endocrine inactive adenomas, 43 prolactinomas, 30 adenomas causing acromegaly, and 17 adenomas causing Cushing's disease or Nelson's syndrome).
A M, Landolt, P U, Heitz, H R, Zenklusen
openaire   +2 more sources

[The pituitary glycoprotein hormones, alpha subunit].

Vnitrni lekarstvi, 1994
Pituitary glycoprotein hormones FSH (follicle-stimulating hormone), LH (luteinizing hormone) and thyrotropic hormone, TSH (thyroid-stimulating hormone) are formed by two subunits: alpha which is essentially the same for all three hormones, and beta which is responsible for their biochemical specificity. The alpha subunit is from the quantitative aspect
openaire   +1 more source

Characterization of Glycoprotein Hormone Free α-Subunit from Human Pituitary and Placenta Extracts

Hormone Research, 1986
Standard alpha-subunit dissociated from glycoprotein hormones differs from individual (free) alpha-subunit found in sera or in cell culture media; secreted free alpha-subunit is larger, more acidic and lacks the ability of recombining in vitro with standard hCG-beta.
R, Chen, E, Barnea, R, Benveniste
openaire   +2 more sources

Rapid maturation of glycoprotein hormone free alpha-subunit (GPHalpha) and GPHalpha alpha homodimers.

Molecular endocrinology (Baltimore, Md.), 2007
The dynamics of glycoprotein hormone alpha-subunit (GPHalpha) maturation and GPHalpha alpha homodimer formation were studied in presence (JEG-3 choriocarcinoma cells) and absence (HeLa cells) of hCGbeta. In both cases, the major initially occurring GPHalpha variant in [35S]Met/Cys-labeled cells carried two N-glycans (M(r app) = 22 kDa).
Jean-Michel, Krause, Peter, Berger, Jordi, Roig, Vinod, Singh, Wolfgang E, Merz   +4 more
openaire   +1 more source

[Eutopic and ectopic production of glycoprotein hormones alpha and beta subunits].

Annales d'endocrinologie, 1997
Human chorionic gonadotropin (hCG) is a glycoprotein composed of two subunits, alpha and beta, linked together by a covalent bond. Ectopic production of hCG has been described in various histological types of cancer. Actually, these malignant tumors predominantly secrete the free beta subunit (hCG beta) and not hCG.
J M, Bidart, E, Baudin, F, Troalen, D, Bellet, M, Schlumberger   +4 more
openaire   +1 more source