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Glycosylated Hemoglobins

The Nurse Practitioner, 1982
Glycosylated hemoglobins are minor components of human red cell hemoglobin, Structurally, they are closely related to adult hemoglobin and are formed nonenzymatically by condensation of glucose or other reducing sugars with hemoglobin A. Biosynthesis, structure and function of these modified hemoglobin molecules as well as their clinical implications ...
Vickie L. Anderson, Camilla Wood
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Glycosylated hemoglobins: increased glycosylation of hemoglobin A in diabetic patients

Diabetes, 1979
The components of the hemoglobin-A1 fraction —hemoglobins A1a-c—arise from nonenzymatic glycosylation of hemoglobin A at the β-chain N-terminal amino groups and can be resolved from hemoglobin A by cation exchange chromatography. Glycosylation can also occur at the α-chain N-terminals as well as the E-amino groups of lysine residues of both α- and β ...
K H, Gabbay   +4 more
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Glycosylated hemoglobins and diabetes mellitus

Human Pathology, 1979
Glycosylated hemoglobins result from post-translational changes in the hemoglobin molecule, and their levels correlate well with glycemic levels over the previous six to 10 weeks. Their use as an aid in monitoring diabetic control appears to be well established, but their value in predicting complications of diabetes and in diagnosing milder forms of ...
J M, McDonald, J E, Davis
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The clinical utility of glycosylated hemoglobin

The American Journal of Medicine, 1981
Measurement of glycosylated hemoglobins in diabetic patients has been available to clinicians for about five years. Such measurements correlate with mean serum glucose determinations over time; therefore, they have stimulated a number of studies to determine (1) if these assays are useful in diagnosing diabetes, (2) the clinical utility of ...
L, Jovanovic, C M, Peterson
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Glycosylated hemoglobin in chronic alcoholics

Drug and Alcohol Dependence, 1983
Glycosylated hemoglobin (Hb AI) is commonly accepted as a parameter of the last 2-3 months metabolism of the glucides; therefore its growth must be proportionate to the metabolic unbalance [1]. We observed that chronic alcoholics often had significantly increased levels of Hb AI when compared with normal controls, although with a normal oral glucose ...
G, Proto, S, De Marchi, E, Cecchin
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A Case of Pseudoelevation of Glycosylated Hemoglobin

Clinical Laboratory
Glycosylated hemoglobin (HbA1c) is a stable compound in human blood that covalently binds the N-terminal valine residue of the β-chain in hemoglobin A to the free aldehyde group of glucose. It can reflect the average blood glucose level of patients in the past 2 - 3 months. Therefore, the accuracy of HbA1c detection results is of great significance for
Gangfeng, Li   +3 more
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Glycosylated Hemoglobin Measurements and Diabetes

JAMA: The Journal of the American Medical Association, 1982
To the Editor.— The glycosylated hemoglobin (Hb A 1 ) test results used to estimate the prevalence of unrecognized diabetes among patients admitted to a coronary care unit are of interest; however, I was a bit stressed by the conclusions of Norman G. Soler, MD, PhD, and Stuart Frank, MD (1981;246:1690).
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Is Glycosylated Hemoglobin Clinically Useful?

New England Journal of Medicine, 1984
The chemical reaction between glucose and hemoglobin is an example of a widespread biologic process called "nonenzymatic glycosylation" (more properly called "glucosylation," in reference to glucos...
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Glycosylation of invertebrate hemoglobins

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1990
Abstract 1. 1. The coelomic, water vascular and intestinal hemoglobins of the sea cucumber Molpadia arenicola have been assayed by phenylboronate affinity chromatography and found to contain 5.5%, 1.3% and 4.4% glycosylated hemoglobin, respectively. 2. 2. The intracellular hemoglobins from the clam Barbatia reeveana and the innkeeper worm
Gene D. McDonald, G.Barrie Kitto
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The Effect of Hemoglobin F Upon Glycosylated Hemoglobin Determinations

American Journal of Clinical Pathology, 1982
Glycosylated hemoglobin (Hgb A1) determinations have been advocated for monitoring the control of diabetes mellitus. The prevalent method today for measuring Hgb A1 for most clinical laboratories has been a "mini-column" utilizing ion exchange chromatography.
J R, Krause, V, Stolc, E, Campbell
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