Engineering the glyoxylate cycle for chemical bioproduction [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 With growing concerns about environmental issues and sustainable economy, bioproduction of chemicals utilizing microbial cell factories provides an eco-friendly alternative to current petro-based processes.
Peng Yang +3 more
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Permeability of the peroxisomal membrane: lessons from the glyoxylate cycle [PDF]
Frontiers in Physiology, 2013 Glyoxylate serves as intermediate in various metabolic pathways, although high concentrations of this metabolite are toxic to the cell. In many organisms glyoxylate is fed into the glyoxylate cycle. Enzymes participating in this metabolism are located on
Markus eKunze, Andreas eHartig
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The Methylcitrate Cycle and Its Crosstalk with the Glyoxylate Cycle and Tricarboxylic Acid Cycle in Pathogenic Fungi [PDF]
Molecules, 2023 In fungi, the methylcitrate cycle converts cytotoxic propionyl-coenzyme A (CoA) to pyruvate, which enters gluconeogenesis. The glyoxylate cycle converts acetyl-CoA to succinate, which enters gluconeogenesis.
Zhicheng Huang +8 more
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Cellular responses of Candida albicans to phagocytosis and the extracellular activities of neutrophils are critical to counteract carbohydrate starvation, oxidative and nitrosative stress. [PDF]
PLoS ONE, 2012 Neutrophils are key players during Candida albicans infection. However, the relative contributions of neutrophil activities to fungal clearance and the relative importance of the fungal responses that counteract these activities remain unclear.
Pedro Miramón +6 more
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The Glyoxylate Cycle Is Involved in White-Opaque Switching in Candida albicans [PDF]
Journal of Fungi, 2021 Candida albicans is a commensal yeast that inhabits the gastrointestinal tract of humans. The master regulator of the white-opaque transition WOR1 has been implicated in the adaptation to this commensal status.
Susana Hidalgo Vico +4 more
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Fat-to-glucose interconversion by hydrodynamic transfer of two glyoxylate cycle enzyme genes [PDF]
Lipids in Health and Disease, 2008 The glyoxylate cycle, which is well characterized in higher plants and some microorganisms but not in vertebrates, is able to bypass the citric acid cycle to achieve fat-to-carbohydrate interconversion.
Marzo F +4 more
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The glyoxylate cycle and alternative carbon metabolism as metabolic adaptation strategies of Candida glabrata: perspectives from Candida albicans and Saccharomyces cerevisiae [PDF]
Journal of Biomedical Science, 2019 Background Carbon utilization and metabolism are fundamental to every living organism for cellular growth. For intracellular human fungal pathogens such as Candida glabrata, an effective metabolic adaptation strategy is often required for survival and ...
Shu Yih Chew +2 more
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Precise tuning of the glyoxylate cycle in Escherichia coli for efficient tyrosine production from acetate [PDF]
Microbial Cell Factories, 2019 Background Acetate is one of promising feedstocks owing to its cheap price and great abundance. Considering that tyrosine production is gradually shifting to microbial production method, its production from acetate can be attempted to further improve the
Minji Jo +6 more
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Mycobacterium smegmatis GlnR Regulates the Glyoxylate Cycle and the Methylcitrate Cycle on Fatty Acid Metabolism by Repressing icl Transcription [PDF]
Frontiers in Microbiology, 2021 Mycobacterium smegmatis (Msm), along with its pathogenic counterpart Mycobacterium tuberculosis (Mtb), utilizes fatty acids and cholesterol as important carbon and energy sources during the persistence within host cells.
Nan Qi +4 more
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Fatty acid feedstocks enable a highly efficient glyoxylate‐TCA cycle for high‐yield production of β‐alanine [PDF]
mLife, 2022 Metabolic engineering to produce tricarboxylic acid (TCA) cycle‐derived chemicals is usually associated with problems of low production yield and impaired cellular metabolism. In this work, we found that fatty acid (FA) feedstocks could enable high‐yield
Yingchun Miao +5 more
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