Engineering the glyoxylate cycle for chemical bioproduction [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 With growing concerns about environmental issues and sustainable economy, bioproduction of chemicals utilizing microbial cell factories provides an eco-friendly alternative to current petro-based processes.
Peng Yang +3 more
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Mycobacterium smegmatis GlnR Regulates the Glyoxylate Cycle and the Methylcitrate Cycle on Fatty Acid Metabolism by Repressing icl Transcription [PDF]
Frontiers in Microbiology, 2021 Mycobacterium smegmatis (Msm), along with its pathogenic counterpart Mycobacterium tuberculosis (Mtb), utilizes fatty acids and cholesterol as important carbon and energy sources during the persistence within host cells.
Nan Qi +4 more
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Permeability of the peroxisomal membrane: lessons from the glyoxylate cycle [PDF]
Frontiers in Physiology, 2013 Glyoxylate serves as intermediate in various metabolic pathways, although high concentrations of this metabolite are toxic to the cell. In many organisms glyoxylate is fed into the glyoxylate cycle. Enzymes participating in this metabolism are located on
Markus eKunze, Andreas eHartig
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The Glyoxylate Cycle Is Involved in White-Opaque Switching in Candida albicans [PDF]
Journal of Fungi, 2021 Candida albicans is a commensal yeast that inhabits the gastrointestinal tract of humans. The master regulator of the white-opaque transition WOR1 has been implicated in the adaptation to this commensal status.
Susana Hidalgo Vico +4 more
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The Methylcitrate Cycle and Its Crosstalk with the Glyoxylate Cycle and Tricarboxylic Acid Cycle in Pathogenic Fungi [PDF]
Molecules, 2023 In fungi, the methylcitrate cycle converts cytotoxic propionyl-coenzyme A (CoA) to pyruvate, which enters gluconeogenesis. The glyoxylate cycle converts acetyl-CoA to succinate, which enters gluconeogenesis.
Zhicheng Huang +8 more
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The glyoxylate cycle and alternative carbon metabolism as metabolic adaptation strategies of Candida glabrata: perspectives from Candida albicans and Saccharomyces cerevisiae [PDF]
Journal of Biomedical Science, 2019 Background Carbon utilization and metabolism are fundamental to every living organism for cellular growth. For intracellular human fungal pathogens such as Candida glabrata, an effective metabolic adaptation strategy is often required for survival and ...
Shu Yih Chew +2 more
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Precise tuning of the glyoxylate cycle in Escherichia coli for efficient tyrosine production from acetate [PDF]
Microbial Cell Factories, 2019 Background Acetate is one of promising feedstocks owing to its cheap price and great abundance. Considering that tyrosine production is gradually shifting to microbial production method, its production from acetate can be attempted to further improve the
Minji Jo +6 more
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Metabolic modeling and comparative biochemistry in glyoxylate cycle [PDF]
Acta Scientiarum: Biological Sciences, 2016 Glyoxylate cycle in fatty acid catabolism enhances net production of oxaloacetate, a substrate for gluconeogenesis, in certain bacteria, invertebrates and oilseed in the growth stage.
Itamar Luís Gonçalves +3 more
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Efficiency of vanillin in impeding metabolic adaptability and virulence of Candida albicans by inhibiting glyoxylate cycle, morphogenesis, and biofilm formation [PDF]
Current Medical Mycology, 2020 Background and Purpose: Candida albicans is the fourth most common cause of nosocomial fungal infections across the world. The current drug regimens are suffering from such drawbacks as drug resistance, toxicity, and costliness; accordingly, they ...
Venkata Saibabu +4 more
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Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle [PDF]
Nature Communications, 2018 The citric acid cycle (TCA) is a fundamental metabolic pathway to release stored energy in living organisms. Here, the authors report two linked cycles of reactions that each oxidize glyoxylate into CO2 and generate intermediates shared with the modern ...
Greg Springsteen +4 more
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