Results 61 to 70 of about 16,670 (212)

Sulfated Polysaccharides From Gracilaria gracilis (Red Seaweed) Restores Testicular Glucose Metabolism by Improving FSH and Insulin Signaling in Rats With Type 2 Diabetes

Molecular Nutrition &Food Research, EarlyView.
Sulfated polysaccharides from red seaweed improved testicular FSH and insulin signaling, which upregulated GLUT4 level and improved glycolysis and energy metabolism in testes of diabetic rats. ABSTRACT Testicular glucose homeostasis plays important roles in testicular energy metabolism and male fertility, but it is altered in type 2 diabetes (T2D ...
Ochuko L. Erukainure, Tosin A. Olasehinde, Olanrewaju S. Olayeriju, Bukola Omotoso, Md. Shahidul Islam, Ademola O. Olaniran   +5 more
wiley   +1 more source

Structural insights into the inhibition properties of archaeon citrate synthase from Metallosphaera sedula.

PLoS ONE, 2019
Metallosphaera sedula is a thermoacidophilic archaeon and has an incomplete TCA/glyoxylate cycle that is used for production of biosynthetic precursors of essential metabolites. Citrate synthase from M.
Seul Hoo Lee, Hyeoncheol Francis Son, Kyung-Jin Kim   +2 more
doaj   +1 more source

Optimum flux rerouting for efficient production of naringenin from acetate in engineered Escherichia coli

Biotechnology for Biofuels and Bioproducts, 2022
Background Microbial production of naringenin has received much attention owing to its pharmaceutical applicability and potential as a key molecular scaffold for various flavonoids.
Dong Hwan Kim, Hyun Gyu Hwang, Gyoo Yeol Jung   +2 more
doaj   +1 more source

Comparative Analysis of Heat Exposure‐Induced Molecular Changes in Two Turtle Species with Contrasting Thermal Adaptations

Integrative Zoology, EarlyView.
Protein processing in the endoplasmic reticulum is highlighted in response to heat stress in Platysternon megacephalum. Under heat stress, the up‐regulation of genes such as CHOP in protein processing in the endoplasmic reticulum pathway, along with the suppression of energy and lipid metabolism and the up‐regulation of JARID2 expression, leads to ...
Jian Hong, Yangchun Gao, Jiaxuan Li, Yan Ge, Yufeng Wei, Youqiang Yin, Qianru Liang, Shiping Gong   +7 more
wiley   +1 more source

Combined GC- and UHPLC-HR-MS Based Metabolomics to Analyze Durable Anti-fungal Resistance Processes in Cereals

CHIMIA, 2017
Introduction of durable resistance genes in crops is an important strategy to prevent yield loss caused by pathogens. The durable multi-pathogen resistance gene Lr34 originating from wheat is widely used in breeding, and is functionally ...
Rahel Bucher, Daniel Veyel, Lothar Willmitzer, Simon Krattinger, Beat Keller, Laurent Bigler   +5 more
doaj   +1 more source

Tryptophan derivatives as non‐invasive diagnostic indicators for obesity‐related MASLD in children and adolescents

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) represents a major health burden in children and adolescents with obesity. This study aimed to characterize metabolic alterations associated with obesity‐related MASLD and to evaluate the potential of tryptophan (TRP)‐derived metabolites as non‐invasive biomarkers for early ...
Shumin Zhan, Xingyun Wang, Chen Wang, Bowen Zhu, Jianfang Gao, Zhou Peng, Rui Wang, Yun Yang, Liang Zhang, Tengfei Wang, Jiaoxiang Wu, Wei Wu, Ke Huang, Guanping Dong, Qiannan Ren, Shan Wang, Senjie Wang, Xuelian Zhou, Liling Xu, Junfen Fu, Xirong Guo   +20 more
wiley   +1 more source

A central role for the peroxisomal membrane in glyoxylate cycle function

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2006
The glyoxylate cycle provides the means to convert C2-units to C4-precursors for biosynthesis, allowing growth on fatty acids and C2-compounds. The conventional view that the glyoxylate cycle is contained within peroxisomes in fungi and plants is no longer valid. Glyoxylate cycle enzymes are located both inside and outside the peroxisome.
Itsara Pracharoenwattana, Markus Kunze, Steven M. Smith, Andreas Hartig   +3 more
openaire   +4 more sources

A short peptide derived from late embryogenesis abundant proteins enhances acid tolerance in Escherichia coli via modulation of two‐component regulatory systems

The FEBS Journal, EarlyView.
Expression of the LEA‐K peptide in E. coli BL21 (DE3) improved bacterial viability under acidic stress (pH4), suggesting a protective function. RNA‐sequencing of LEA‐K‐expressing vs. non‐expressing cells revealed 283 differentially expressed genes (DEGs). In silico docking linked LEA‐K to two‐component systems (TCS) proteins (Rcs, BtsS/R, and EnvZ/OmpR)
Khaled Metwally, Shinya Ikeno
wiley   +1 more source

Multifaceted roles of metabolic enzymes of the Paracoccidioides species complex

Frontiers in Microbiology, 2014
Paracoccidioides species are dimorphic fungi, and are the etiologic agents of paracoccidioidomycosis (PCM), a serious disease of multiple organs. The large number of tissues colonized by this fungus suggests the presence of a variety of surface molecules
Caroline Maria Marcos, Haroldo César de Oliveira, Julhiany de Fátima da Silva, Patricia Akemi Assato, Ana Marisa eFusco-Almeida, Maria José Soares Mendes-Giannini   +5 more
doaj   +1 more source

Contextualized Metabolic Modelling Revealed Factors Affecting Isoflavone Accumulation in Soybean Seeds

Plant, Cell &Environment, EarlyView.
ABSTRACT Isoflavones, secondary metabolites with numerous health benefits, are predominantly found in legume seeds, especially soybean; however, their contents in domesticated soybean seeds are highly variable. Wild soybeans are known for higher seed isoflavone contents than cultivars. Here we used experimental and modelling approaches on wild soybean (
Carolina A. Contador, Ailin Liu, Ming‐Sin Ng, Yee‐Shan Ku, Siu H. J. Chan, Hon‐Ming Lam   +5 more
wiley   +1 more source