Results 211 to 220 of about 19,645 (252)

Structural and dynamic views of GM1 ganglioside

Glycoconjugate Journal, 2015
The ganglioside GM1 mediates various physiological and pathological processes mainly through the formation of GM1 clusters on cell surfaces. Therefore, detailed characterization of conformational properties of the glycan moiety of GM1 and the structures and interactions of this glycosphingolipid in membrane environments is necessary for better ...
Maho, Yagi-Utsumi, Koichi, Kato
openaire   +2 more sources

Total synthesis of gangliosides GM1 and GM2

Carbohydrate Research, 1986
Synthese de (O-glycosyl N-tetracosanoyl) sphingosines.
M, Sugimoto, M, Numata, K, Koike, Y, Nakahara, T, Ogawa   +4 more
openaire   +2 more sources

Organization of ganglioside GM1 in phosphatidylcholine bilayers

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1985
Molecules of the ganglioside GM1 are randomly distributed in liquid-crystalline 1-palmitoyl-2-oleoyl phosphatidylcholine bilayers. This conclusion is based on a freeze-etch electron microscopic study using ferritin-conjugated cholera toxin and cholera toxin alone as ganglioside labels.
T E, Thompson, M, Allietta, R E, Brown, M L, Johnson, T W, Tillack   +4 more
openaire   +2 more sources

Conformational study of asialo-GM1 (GA1) ganglioside

Biopolymers, 1997
In order to investigate the significance of preferred conformations of the saccharide for the steric orientation and recognition of glycosphingolipids at the membrane surface, the conformational free energy calculations were carried out on the asialo-GM1 [GA1; beta-D-Gal (1-->3) beta-D-GalNac(1-->4) beta-D-Gal(1-->4) beta-D-Glc-O-ceramide) using a new ...
H J, Park, G J, Jhon, S J, Han, Y K, Kang   +3 more
openaire   +2 more sources

GM1 ganglioside and Alzheimer’s disease

Glycoconjugate Journal, 2015
Assembly and deposition of amyloid ß-protein (Aß) is an invariable and fundamental event in the pathological process of Alzheimer's disease (AD). To decipher the AD pathogenesis and also to develop disease-modifying drugs for AD, clarification of the molecular mechanism underlying the Aß assembly into amyloid fibrils in the brain has been a crucial ...
openaire   +2 more sources

Trifluoromethyl Derivatization of the Ganglioside, GM1

Synthesis, 2010
A practical synthetic route to a terminally trifluoromethylatedanalogue of the ganglioside G M1 is described. It is basedon regioselective chemical manipulation of naturally occurring G M1 isolatedfrom bovine brain. Lyso-G M1 obtained by simple chemical transformationwas then simply acylated with the NHS ester of trifluorostearicacid. The ability
Krishna Kumar, Zhao Liu
openaire   +1 more source

GM1 Ganglioside: Past Studies and Future Potential

Molecular Neurobiology, 2015
Gangliosides (sialic acid-containing glycosphingolipids) are abundant in neurons of all animal species and play important roles in many cell physiological processes, including differentiation, memory control, cell signaling, neuronal protection, neuronal recovery, and apoptosis.
M. Aureli, L. Mauri, M.G. Ciampa, A. Prinetti, G. Toffano, C. Secchieri, S. Sonnino   +6 more
openaire   +2 more sources

Mimicking Gangliosides by Design: Mimics of GM1 Headgroup

Neurochemical Research, 2002
Detailed knowledge of the three-dimensional structure of ganglioside headgroups has allowed the successful design of structural and functional mimics of ganglioside GMI oligosaccharide. Our recent work in this area is reviewed in this paper.
A. Bernardi, D. Arosio, S. Sonnino
openaire   +2 more sources

Is Ganglioside GM1 Effective in the Treatment of Stroke?

Drugs & Aging, 1991
Nine double-blind, placebo-controlled clinical trials involving 784 patients with nonhaemorrhagic stroke have been reviewed to investigate the clinical efficacy of ganglioside GM1 in this disorder. The evaluated data show a statistically significant, but transient, acceleration in recovery from neurological deficits in 63% of all GM1-treated patients ...
openaire   +2 more sources

Synthesis of a Pseudo Tetrasaccharide Mimic of Ganglioside GM1

European Journal of Organic Chemistry, 1999
The pseudo tetrasaccharide 2 was designed to mimic ganglioside GM1, the membrane receptor of both the cholera toxin and of the heat-labile toxin of E. coli. Compound 2 retains the Gal and Neu5Ac recognition determinant of GM1 and uses as the scaffold element a new, conformationally restricted cyclohexanediol (DCCHD 3), with the same relative and ...
A. Bernardi, G. Boschin, A. Checchia, M. Lattanzio, L. Manzoni, D. Potenza, C. Scolastico   +6 more
openaire   +3 more sources