Исследование острой токсичности ГИЖ-298 [PDF]
, 2021 Assessment of acute toxicity is a necessary stage of preclinical research of the substance GIZh-298. The aim of present research is study of acute toxicity GIZh-298. Methods. GIZh-298 was administered once intraperitoneally to mice at doses 200-330 mg/kg.
А. Д. Захаров +15 more
core +4 more sources
Additional file 11 of MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration [PDF]
, 2021 Additional file 11. Intrathecal pre-treatment with LPS enhances miR-298-5p- and miR-100-5p-induced neurodegeneration and microglial accumulation. 1 μg LPS was injected intrathecally into C57BL/6 mice.
Michal Szczepek (4950643) +18 more
core +1 more source
Additional file 10 of MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration [PDF]
, 2021 Additional file 10. Intrathecal brain-derived, small RNA triggers neurodegeneration. 125 pmol of an LNA inhibitor specific for mmu-miR-298-5p (miR-298-I), an LNA negative control inhibitor (neg.
Michal Szczepek (4950643) +18 more
core +1 more source
Additional file 5 of MicroRNA-100-5p and microRNA-298-5p released from apoptotic cortical neurons are endogenous Toll-like receptor 7/8 ligands that contribute to neurodegeneration [PDF]
, 2021 Additional file 5. Low dose response of miR-100-5p- and miR-298-5p-treated microglia and HEK293 hTLR7/8 reporter cells. (a) Images of C57BL/6 microglia incubated with 5 μg/ml of miR-100-5p or miR-298-5p, or PBS (control) for 4 h. Subsequently, cells were
Michal Szczepek (4950643) +18 more
core +1 more source
Development of the circadian system in early life: maternal and environmental factors
Journal of Physiological Anthropology, 2022 In humans, an adaptable internal biological system generates circadian rhythms that maintain synchronicity of behavior and physiology with the changing demands of the 24-h environment.
Sachi D. Wong +6 more
doaj +1 more source
Do green-blocking glasses enhance the nonvisual effects of white polychromatic light?
Journal of Physiological Anthropology, 2018 Background It is well known that light containing the blue component stimulates the intrinsically photosensitive retinal ganglion cells (ipRGCs) and plays a role in melatonin suppression and pupillary constriction.
Soomin Lee +2 more
doaj +1 more source
Journal of Physiological Anthropology, 2020 Background Age-related changes affect driving ability, including the smoothness of driving. This operation requires the use of both allocentric strategies (based on world-centered representations) and egocentric strategies (based on self-centered ...
Masafumi Kunishige +5 more
doaj +1 more source
Which characteristic of Natto: appearance, odor, or taste most affects preference for Natto
Journal of Physiological Anthropology, 2012 Background In Japan, consumption of Natto, a fermented bean dish, is recommended because of its high quality protein, digestibility in the gut and its preventive effect on blood clot formation due to high vitamin K content.
Tsumura Yuki +3 more
doaj +1 more source
Non-cotton swab sample collection may not affect salivary melatonin assay results
Journal of Physiological Anthropology, 2018 Background Salivary melatonin levels have been analyzed in many research fields, including physiological anthropology. Although various devices have been utilized for saliva collection, cotton swabs are among the most common.
Tomoaki Kozaki, Yuki Hidaka
doaj +1 more source
Journal of Physiological Anthropology, 2012 Background This study aimed to present normative reference values of heart rate variability and salivary alpha-amylase in a healthy young male population with a particular focus on their distribution and reproducibility. Methods The short-term heart rate
Kobayashi Hiromitsu +2 more
doaj +1 more source