Results 41 to 50 of about 900,711 (239)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

CSF Levels of NPTX2 Are Associated With Less Brain Atrophy Over Time in Cognitively Unimpaired Individuals

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Introduction Neuronal pentraxin 2 (NPTX2) is a synaptic protein involved in synaptic plasticity and regulation of neuronal excitability. Lower baseline cerebrospinal fluid (CSF) NPTX2 levels have been shown to be associated with an earlier onset of mild cognitive impairment (MCI), a pre‐dementia syndrome, even after CSF Alzheimer's Disease (AD)
Juan P. Vazquez, Corinne Pettigrew, Yuxin Zhu, Claire Anderson, Guray Erus, Christos Davatzikos, Michael Miller, Abhay Moghekar, Sungtaek Oh, Chan‐Hyun Na, Marilyn Albert, Paul Worley, Anja Soldan   +12 more
wiley   +1 more source

Complexity metrics for measuring the understandability and maintainability of Business Process Models using Goal-Question-Metric (GQM) [PDF]

, 2008
Business Process Models (BPMs), often modeling language such as UML activity between the created using stakeholders in the can provide us a diagrams, Event- Driven Process Chains Markup Language (EPML) and Yet Another Workflow Language (YAWL), serve as a
Abd Ghani, Abdul Azim, Koh, Tieng Wei, Muketha, Geoffrey Muchiri, Wong, Pei Wen   +3 more
core  

A Scoping Review on Artificial Intelligence–Supported Interventions for Nonpharmacologic Management of Chronic Rheumatic Diseases

Arthritis Care &Research, EarlyView.
This review summarizes artificial intelligence (AI)‐supported nonpharmacological interventions for adults with chronic rheumatic diseases, detailing their components, purpose, and current evidence base. We searched Embase, PubMed, Cochrane, and Scopus databases for studies describing AI‐supported interventions for adults with chronic rheumatic diseases.
Nirali Shah, Alexis Castellanos, Yen Chen, John Piette, Amy Bucher, Susan Murphy   +5 more
wiley   +1 more source

Goal and Risk Factors in Offshore Outsourced Software Development from Vendor's Viewpoint

2009 Fourth IEEE International Conference on Global Software Engineering, 2009
Reducing production cost is vital for ensuring sustainable competitive strength. This is particularly true in software development, in which there has been a move from in-house development to global and now also to offshore-outsourced software ...
Shareeful Islam, Md. Mahbubul Alam Joarder, S. Houmb   +2 more
semanticscholar   +1 more source

Development of a Personalized Visualization and Analysis Tool to Improve Clinical Care in Complex Multisystem Diseases With Application to Scleroderma

Arthritis Care &Research, EarlyView.
Objective In complex diseases, it is challenging to assess a patient's disease state, trajectory, treatment exposures, and risk of multiple outcomes simultaneously, efficiently, and at the point of care. Methods We developed an interactive patient‐level data visualization and analysis tool (VAT) that automates illustration of the trajectory of a ...
Ji Soo Kim, John Scott, Lauren Fisher, Lauren N. Smith, Willie Stewart, Adrianne Woods, Rob Smithwright, Diane Koher, Parastoo Aslanbeik, Aalok B. Shah, Brad Tibbils, Samantha I. Pitts, Ayse P. Gurses, Yushi Yang, Ana‐Maria Orbai, Antony Rosen, Laura K. Hummers, Scott L. Zeger, Ami A. Shah   +18 more
wiley   +1 more source

Development of a Digital Health Intervention for the Secondary Prevention of Cardiovascular Disease (INTERCEPT): Co-Design and Usability Testing Study

JMIR Human Factors
BackgroundSecondary prevention is an important strategy to reduce the burden of cardiovascular disease (CVD), a leading cause of death worldwide.
Irene Gibson, Lis Neubeck, Marissa Corcoran, Chris Morland, Steve Donovan, Jennifer Jones, Caroline Costello, Lisa Hynes, Aisling Harris, Mary Harrahill, Mary Lillis, Alison Atrey, Chantal F Ski, Vilius Savickas, Molly Byrne, Andrew W Murphy, John William McEvoy, David Wood, Catriona Jennings   +18 more
doaj   +1 more source

RESEARCH ON ARTIFICIAL INTELLIGENCE TOOLS FOR AUTOMATING THE SOFTWARE TESTING PROCESS

Bulletin of National Technical University KhPI Series System Analysis Control and Information Technologies
The subject matter of the article is artificial intelligence (AI) tools for automating the software testing process. The rapid development of the software development industry in recent decades has led to a significant increase in competition in the IT ...
O. Vorochek, I. Solovei
semanticscholar   +1 more source

Evaluating the Impact of Critical Factors in Agile Continuous Delivery Process: A System Dynamics Approach [PDF]

, 2014
Continuous Delivery is aimed at the frequent delivery of good quality software in a speedy, reliable and efficient fashion – with strong emphasis on automation and team collaboration. However, even with this new paradigm, repeatability of project outcome
Akerele, O, Dixon, MB, Ramachandran, M
core   +1 more source