Results 111 to 120 of about 11,733,399 (339)

4th and Goal: What is the Interpretive Touchdown? [PDF]

, 2012
What is the aim of historic interpretation? That seems like it would be a simple question to answer, but it\u27s simply not. Historic interpretation seems to be a many headed Hydra, with each interpreter seeing their own purpose and their own goals ...
Rudy, John M.
core   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

CURIOUS: Intrinsically Motivated Modular Multi-Goal Reinforcement Learning [PDF]

, 2019
In open-ended environments, autonomous learning agents must set their own goals and build their own curriculum through an intrinsically motivated exploration.
Chetouani, Mohamed, Colas, Cédric, Fournier, Pierre, Oudeyer, Pierre-Yves, Sigaud, Olivier   +4 more
core   +2 more sources

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

A goal model for crowdsourced software engineering [PDF]

, 2018
Crowdsourced Software Engineering (CSE) is the act of undertaking any external software engineering tasks by an undefined, potentially large group of online workers in an open call format.
Franch Gutiérrez, Javier, Siyal, Fiza
core  

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Are People More Averse of Their Peers Living in Hardship or Driving Luxury Cars? Individuals’ Willingness to Accept Their Peers’ Relative Circumstances

Behavioral Sciences
Are people more afraid of peers living in hardship or peers driving luxury cars? Tri-Reference Point theory posits that individuals prioritize others’ minimum requirements over their goals.
Xiaohan Hu, Jie Liu, Fengyang Sun, Xiuxin Wang   +3 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Yrkesämnesdidaktik på universitet: Mål, innehåll, arbetssätt och examination [Vocational subject didactics at university: Learning goals, content, working methods and exams]

Nordic Journal of Vocational Education and Training, 2019
The purpose of this article is to investigate learning goals, content, working methods and examinations in the vocational didactic sections of the vocational teacher education programme.
Annelie Andersén, Hamid Asghari, Maria Petersson   +2 more
doaj   +1 more source