Results 81 to 90 of about 1,008,460 (342)
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
On solving fully fuzzy multi-criteria De Novo programming via fuzzy goal programming approach
Journal of Applied Research on Industrial Engineering, 2018 In this paper, a Multi-Criteria De Novo Linear Programming (F- MDNLP) problem has been developed under consideration of the ambiguity of parameters. These fuzzy parameters are characterized by fuzzy numbers.
Hamiden Abdelwahed Khalifa
doaj +1 more source
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
Aging and Cancer, EarlyView.As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
A goal programming technique for railroad passenger scheduling [PDF]
Management Science Letters, 2012 Railroad industry has received tremendous challenges in the world in terms of handling cost and efficiency. For many years, the railroad business lost money in many countries such as Japan until many governments decided to privatize the industry in an ...
Masoud Yaghini +2 more
doaj
APPLICATION OF LINEAR GOAL PROGRAMMING TO FOREST HARVEST SCHEDULING [PDF]
Resource /Energy Economics and Policy,
Hotvedt, James E.
core +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
Appendix M: GAMS Programming Code for the Wik Forestry Goal Programming Model [PDF]
, 2008 GAMS Programming Code for the Wik Forestry Goal Programming ...
Tyron J. Venn
core
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source