Results 221 to 230 of about 2,502,296 (297)

Identification of the Potential chi-miR-148a-5p-PTGS2 Regulatory Axis Mediating TNF and IL-17 Signaling Pathways in Caprine Bronchial Epithelial Cells Challenged with Klebsiella Pneumoniae. [PDF]

Vet Sci
Chen Y, Gong Z, Jing H, Duan H, Qian H, Li T, Niu S, Wu L, Wang Z, Zhang M, Cheng Y, Man C, Chen Q, Du L, Chen S, Gao H, Wang F.   +16 more
europepmc   +1 more source

A Small‐Molecule DEPTAC Rescues Cognitive Deficits by Targeted Dephosphorylation of Pathological Tau

Advanced Science, EarlyView.
TP2 is a fully synthetic small‐molecule dephosphorylation‐targeting chimera that recruits endogenous PP2A‐Bα to Tau, enabling targeted removal of pathological phosphate modifications. In two tauopathy mouse models, systemic TP2 reduces Tau pathology, preserves neuronal and synaptic integrity, improves neuroimmune homeostasis, and rescues cognition ...
Fei Sun, Yang Liu, Qiuzhi Zhou, Qingyuan Hu, Weixia Wang, Yue Xiao, Jingfen Su, Guanting Liu, Miaomiao Sun, Lixia Chen, Hua Li, Ying Yang, Jian‐Zhi Wang   +12 more
wiley   +1 more source

Addition of multi-locus variable number tandem repeat analysis to assist <i>Cryptosporidium parvum</i> foodborne outbreak investigation - France, 2025. [PDF]

Food Waterborne Parasitol
Chereau F, Rageot D, Puzin L, Dalle F, Buser GL, Lalan L, Dorgebray PE, Laurent E, Stoica MA, Fredriksen N, Favennec L, Costa D, de Valk H.   +12 more
europepmc   +1 more source

PROTAC‐Engineered Protein/DNA Nanoantigen is a Potent Booster for Dendritic Cell Vaccines in Cancer Immunotherapy

Advanced Science, EarlyView.
A PROTAC‐functionalized protein/DNA‐integrated nanoantigen platform is developed to enhance dendritic cell vaccine potency. By combining a VHL‐recruiting peptide‐modified antigen with a sustained expression plasmid within CaCO3 nanoparticles, this system amplifies cross‐presentation, promotes DC maturation, and elicits robust Th1 and CTL responses ...
Peng Liu, Qiang Chen, Zhe Zhou, Yuekang Xu, Jinyao Li   +4 more
wiley   +1 more source

Acupoint catgut embedding exerts node-dependent effects on leptin resistance-related signaling and the ghrelin-GOAT pathway in obese mice. [PDF]

Front Nutr
Yang Q, Yang H, Zhang J, Xu N, Zhu C, Yi W, Huang H.   +6 more
europepmc   +1 more source

Kidney‐Targeted Cilastatin Nanoparticles Inhibit DPEP1‐Mediated Ferroptosis for Acute Kidney Injury Therapy

Advanced Science, EarlyView.
In this study, MPDA NPs were engineered to encapsulate CTT. To further increase renal accumulation of CTT, L‐serine was conjugated to the surface of the MPDA nanoparticles (CTT/MPDA@L‐Ser NPs). CTT/MPDA@L‐Ser NPs inhibit DPEP1 activity, thereby restoring ferroptosis defense mechanisms through upregulation of GPX4 and SLC7A11 expression, ultimately ...
Wanbing Qin, Jiaqi Huang, Manting Zhang, Wanchun Yang, Mingwei Xu, Chi Jiang, Jiekai Li, Jinjuan Wen, Qibin Huang, Shiqi Wen, Weidong Wang, Junbing He, Qinghua Liu   +12 more
wiley   +1 more source

Prevalence and Phenotypic Antimicrobial Resistance of <i>Listeria monocytogenes</i> from Animal-Derived Foods: A Scoping Review. [PDF]

Foods
Songor G, Anchundia M.
europepmc   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

Structural Prediction and Antigenic Characterization of Recombinant Nucleocapsid Protein (p14) of Small Ruminant Lentivirus. [PDF]

Viruses
Castañeda-Montes MA, Cerriteño-Sánchez JL, Cuevas-Romero JS, Castañeda-Montes FJ, González-Esparragoza D, Ávila-De la Vega LM, Ramírez-Álvarez H.   +6 more
europepmc   +1 more source

Excessive activation of the RAS/MAPK pathway triggers adult-onset motor axonal degeneration. [PDF]

iScience
Been M, Lambert E, Serna A, Balvert ACG, Heisinger S, Kreshpani M, Te Dorsthorst-Maas C, Paškevičiūtė P, Rodríguez Arias H, Beijer D, Astuti G, Kenna K, van Reijmersdal B, Gloudemans S, van Lith P, Sijlmans C, Verstreken P, Veldink J, Züchner S, Gilissen C, Schenck A, Storkebaum E.   +21 more
europepmc   +1 more source