Results 31 to 40 of about 314,364 (262)

Comparison of sheep and goat colostrum fatty acids contents [PDF]

BIO Web of Conferences
The quality and content of colostrum is a very important factor for the health of the offspring. Colostrum is the first food that ensures the growth and development of offspring and their immunity against diseases.
Anitaş Özgül, Göncü Serap
doaj   +1 more source

Discovery of novel inhibitors of ghrelin O-acyltransferase enzyme: an in-silico approach

Research in Pharmaceutical Sciences, 2022
Background and purpose: Ghrelin is known as a hunger hormone and plays a pivotal role in appetite, food intake, energy balance, glucose metabolism, and insulin secretion, making it a potential target for the treatment of obesity and type 2 diabetes.
Faezeh Sadat Hosseini, Alireza Ghassempour, Massoud Amanlou   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Ethnoveterinary medicines used for mitigating goat diseases in Zimbabwe: A narrative review.

Student's Journal of Health Research Africa
Livestock production, including goat farming, is important for rural development as it provides food security and fast-turnaround cash for the household. However, goats are often susceptible to various diseases and ailments.
Dr. Alfred Maroyi
doaj   +1 more source

Incidence of diseases in goats in Bangladesh

Bangladesh Veterinarian, 2022
An assessment of goat diseases was done in 1808 goats in one farm in Dhaka, Bangladesh. Abortion (1.7%), abscess (1.1%), actinomycosis (1.1%), bloat (2.1%), conjunctivitis (2.6%), diarrhoea (31.1%), dystocia (0.3%), contagious ecthyma (4.4%), fever (2.7%), fox bite (1.1%), lameness (9.0%), malnutrition (3.2%), mange (6.2%), mastitis (1.7%), mechanical (
MH Rahman, S Akther, MZ Ali, MZ Hassan
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Epidemiological Study on Incidence and Major Causes of Pre-Weaning Kid Morbidity and Mortality of Abergelle Goats in Waghemira Zone, Amhara Region, Ethiopia

Blue Nile Journal of Agricultural Research, 2023
Small ruminants, especially goat is very important in the economy and nutrition, and has the potential for using it as a tool for poverty reduction in developing countries.
Ayalew Assefa, Adane Bahiru, Abebe Tibebu   +2 more
doaj  

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source