Results 61 to 70 of about 10,905,136 (285)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Epidemiological Study on Incidence and Major Causes of Pre-Weaning Kid Morbidity and Mortality of Abergelle Goats in Waghemira Zone, Amhara Region, Ethiopia

Blue Nile Journal of Agricultural Research, 2023
Small ruminants, especially goat is very important in the economy and nutrition, and has the potential for using it as a tool for poverty reduction in developing countries.
Ayalew Assefa, Adane Bahiru, Abebe Tibebu   +2 more
doaj  

Sustainable Sheep and Goat Farming in Arid Regions of Jordan

Ruminants
This study examines the sustainability of livestock farming in Jordan’s arid regions, focusing on smallholder Awassi sheep and Baladi goat farming. It assesses breeders, economic factors, herd productivity, and sustainability, evaluating the vitality of ...
Faisal Al-Barakeh, A. O. Khashroum, Radi Tarawneh, F. Al-Lataifeh, Azzam N. Al-Yacoub, M. Dayoub, Khaled Al-Najjar   +6 more
semanticscholar   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Genome-Wide Identification of Specific Genetic Loci Common to Sheep and Goat

Biomolecules
Sheep and goat may become carriers of some zoonotic diseases. They are important livestock and experimental model animals for human beings. The fast and accurate identification of genetic materials originating from sheep and goat can prevent and inhibit ...
Zuoxiang Liang, Xiaoyu Yue, Yangxiu Liu, Mengyan Ye, Ling Zhong, Yue Luan, Qin Wang   +6 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

GOAT FARMING IN THE VRBAS BANOVINA

Истраживања
The aim of the paper is to analyze goat farming in the Vrbas Banovina based on published and unpublished sources and available literature. In certain areas of the Kingdom of Yugoslavia, goat farming was a major branch of stockbreeding. The portion of the
ŽELJKO SAVANOVIĆ
doaj   +1 more source

Nutritional and Health Profile of Goat Products: Focus on Health Benefits of Goat Milk

Goat Science, 2017
Goat (Capra hircus) is one of the main sources of milk and meat products for human consumption. Goat milk differs from cow and human milk in both composition and nutritional properties.
M. J. Lima, Edite Teixeira-Lemos, Jorge Oliveira, Luís Teixeira-Lemos, António Cardoso Monteiro, J. M. Costa   +5 more
semanticscholar   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Milking characteristics, hygiene and management practices in Saanen goat farms: a case of Canakkale province, Turkey

Italian Journal of Animal Science, 2020
In order to determine the current status of milking characteristics, hygiene and health protection practices in Saanen goat farms in Turkey, data were obtained from 92 farms through surveys in Çanakkale province.
Arzu Gökdai, Engin Sakarya, Barbara Contiero, Flaviana Gottardo   +3 more
doaj   +1 more source