Results 161 to 170 of about 734,327 (301)

Integrated miRNA–mRNA Analysis Reveals Obesity‐Driven Regulatory Networks in Human Visceral Adipose Tissue With and Without Type 2 Diabetes

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims Obesity is characterised by pathological alterations in visceral white adipose tissue (vWAT) that may contribute to the development of type 2 diabetes (T2D). While microRNAs (miRNAs) are key post‐transcriptional regulators, comprehensive human vWAT profiling across metabolic states remains limited.
Elsa Villa‐Fernández   +19 more
wiley   +1 more source

Alternancia política y gobiernos locales en México

open access: yesEstudios Sociológicos, 2002
Víctor Alejandro Espinoza Valle
doaj   +1 more source

The media and public agendas: testing for media effects in Argentina during the Kirchner administration [PDF]

open access: yes
In this paper we examine the presence of agenda-setting effects by the print media in Argentina during 2003 and 2008. Using previously unavailable monthly data on newspapers mentions we test two hypotheses about the relationship between the different ...
Juan Carlos Cuestas   +2 more
core  

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

open access: yesThe FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero   +8 more
wiley   +1 more source

Los hechos regionales, base para las estructuras de gobierno en la ciudad-región de Medellín [PDF]

open access: yes
La fusión urbana de los municipios del Área Metropolitana de Medellín,asociada al mejoramiento de las infraestructuras que la conectan con eloriente y occidente cercanos, han cambiado la realidad urbana, regional,social y económica.
Luis Fernando Agudelo Henao
core  

Exploring drivers and costs of partial trans‐Saharan migration in juvenile vultures

open access: yesIbis, EarlyView.
Partial migration occurs when only a subset of individuals within a population undertakes a migratory journey. The decision to migrate can be influenced by intrinsic traits (e.g. sex or physical condition) as well as by extrinsic factors (e.g. social environment or resource availability).
Eneko Arrondo   +18 more
wiley   +1 more source

Oportunidades ambientales de los Gobiernos Locales

open access: yes, 2012
Los gobiernos locales deben contribuir con los esfuerzos nacionales y globales para reducir la contaminación y el agotamiento de recursos naturales que impactan en el cambio climático. Sin duda las municipalidades representan el eslabón institucional más cercano al ciudadano, y ello debe ser aprovechado para que las autoridades ediles implementen ...
Luque Casanave, Manuel   +1 more
openaire   +1 more source

An efficient variable neighborhood search approach for the facility location problem with the limited choice rule

open access: yesInternational Transactions in Operational Research, EarlyView.
Abstract One of the most common problems in the expansion of a company consists of deciding the most appropriate locations for their facilities. This decision problem, known as the facility location problem, has been studied from different perspectives, considering a number of different constraints.
Enrique García‐Galán   +2 more
wiley   +1 more source

A fast metaheuristic approach for the planar multiple obnoxious facility location problem

open access: yesInternational Transactions in Operational Research, EarlyView.
Abstract The multiple obnoxious facility location problem is one of the most studied problems in the literature of the obnoxious facility location problems family. In this work, we propose an alternative algorithmic approach for this problem, based on an efficient metaheuristic procedure over a discretization of the plane based on Voronoi diagrams ...
Sergio Salazar   +2 more
wiley   +1 more source

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