The FEBS Journal, EarlyView.Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero +8 more
wiley +1 more source
De novo development of Clinical Practice Guidelines or adaptation of high-quality international Guidelines. When and how [PDF]
Rev Colomb Obstet GinecolGaitán-Duarte H.
europepmc +1 more source
A fast metaheuristic approach for the planar multiple obnoxious facility location problem
International Transactions in Operational Research, EarlyView.Abstract The multiple obnoxious facility location problem is one of the most studied problems in the literature of the obnoxious facility location problems family. In this work, we propose an alternative algorithmic approach for this problem, based on an efficient metaheuristic procedure over a discretization of the plane based on Voronoi diagrams ...
Sergio Salazar +2 more
wiley +1 more source
Evaluation of Nurse‐Led Triage in the Emergency Department: A Retrospective Observational Study
Journal of Clinical Nursing, EarlyView.ABSTRACT Aim To assess the quality of the Spanish Triage System performed by nurses according to the triage code assigned to each patient and to examine factors associated with the need for re‐evaluation after completion of triage. Design Retrospective longitudinal observational study.
Dolores Selva‐Medrano +9 more
wiley +1 more source
[Commercially available complementary foods in Argentina and Mexico: An analysis of their nutritional composition, labeling, and promotionAlimentos complementares comercializados na Argentina e no México: análise da composição nutricional, rotulagem e promoção]. [PDF]
Rev Panam Salud PublicaZapata ME +7 more
europepmc +1 more source
Voting Red Again: How Social Capital and Local Change Drove the Trump Swing
Journal of Regional Science, EarlyView.ABSTRACT Social capital has long been regarded as a bulwark of democratic life. Yet in the United States—as across much of the democratic world—some of the communities with the densest social ties have proved the most receptive to antisystem politics.
Pedro Fierro +3 more
wiley +1 more source
Deacetylase inhibitors CM‐444 and CM‐1758 enhance chemotherapy response in AML via ALOX5
British Journal of Haematology, EarlyView.
Naroa Gimenez‐Camino +7 more
wiley +1 more source
Nocturnal Sleep Breathing Patterns in Healthy Adolescents Residing at Very High Altitudes in Bolivia
Journal of Sleep Research, EarlyView.ABSTRACT Data on sleep and respiratory patterns among adolescents residing at very high altitude (> 3500 m) remain scarce, and altitude‐related physiological differences may influence these parameters. Studying adolescents at different very high altitudes is crucial, as subtle environmental variations could affect sleep‐related oxygenation and ...
Keaton Patterson +8 more
wiley +1 more source