Results 101 to 110 of about 120,000 (268)

External Control Arms in Japan: A Systematic Case Analysis of Documented Regulatory Implementation and Uncertainty Management

Clinical Pharmacology &Therapeutics, EarlyView.
External control arms (ECAs) have emerged as important tools to provide benchmark evidence on comparator effectiveness and thereby support regulatory decision making in situations where randomized controlled trials are difficult to conduct. However, how key methodological elements for ECAs are documented and implemented in practice and how residual ...
Suguru Okami, Alexandros Sagkriotis
wiley   +1 more source

Antipsychotic Drug Interactions and Short‐Term Mortality Risk in People With Dementia: A National Cohort Study

Clinical Pharmacology &Therapeutics, EarlyView.
Antipsychotics are often prescribed in the management of behaviors and psychological symptoms of dementia. While the potential harms of antipsychotic use in people with dementia have been established, little is known about the risk associated with antipsychotic drug–drug interactions (DDIs). This study aims to examine the patterns of antipsychotic DDIs
Edward C.Y. Lau, Grace H. Shim, Chin Hang Yiu, Sarah N. Hilmer, Yun‐Hee Jeon, Weisi Chen, Christine Y. Lu, Edwin C.K. Tan   +7 more
wiley   +1 more source

Early and High‐Dose Glucocorticoid Use and Survival in Advanced NSCLC Receiving Immune Checkpoint Inhibitors: A Multicenter Target Trial Emulation

Clinical Pharmacology &Therapeutics, EarlyView.
Despite the immunomodulatory mechanism of immune checkpoint inhibitors (ICIs), systemic glucocorticoids are commonly used in advanced non–small cell lung cancer (NSCLC). Evidence regarding their effects on ICI outcomes is inconsistent, in part due to confounding by indication and immortal time bias.
Da Eun Lee, Geunho Lim, Minoh Ko, Mari Kim, Ji Sun Chun, Borim Lee, Miso Kim, Kwangsoo Kim, Byung Kwan Choi, Jeongmin Seo, Jin Hyoung Kang, Taehoon Ko, In‐Wha Kim, Jung Mi Oh   +13 more
wiley   +1 more source

Defining Reconciliation Studies: Theoretical and Practical Dimensions

Conflict Resolution Quarterly, EarlyView.
ABSTRACT Reconciliation studies (RS) has become increasingly influential in understanding alternative views to ending conflict and dealing with the aftermath. As a discipline or field, however, it is not well defined. The actual usefulness of reconciliation (as a concept), or of RS (as a discipline), is debated, and due to its growing usage, it is ...
Colleen Alena O’Brien
wiley   +1 more source

A shining starlet: Nematostella vectensis as a model for developmental, regenerative, and comparative biology

Developmental Dynamics, EarlyView.
Abstract The sea anemone, Nematostella vectensis, has been used as a model organism in developmental biology studies for many years. This estuarine species has the notable capacity to regenerate its full body plan from small pieces throughout life. Nematostella have been described as having a great degree of cellular plasticity.
Patrick A. Lewis, Zachary Horowitz, Michael Shribak, Karen Echeverri   +3 more
wiley   +1 more source

eGFR slope as predictor of mortality in heart failure patients

ESC Heart Failure, Volume 12, Issue 2, Page 1217-1226, April 2025.
Abstract Aims Heart failure (HF) leads to an imbalance between heart and kidney function, resulting in poor outcomes. However, the prognostic significance of the estimated glomerular filtration rate (eGFR) trajectory in HF patients remains unclear. We analysed electronic health records (EHRs) of real‐world HF patients, assessing eGFR trajectories and ...
Sofie Verstreken, Monika Beles, Clara L. Oeste, Ana Moya, Imke Masuy, Riet Dierckx, Ward Heggermont, Jeroen Dauw, Dries Hens, Jozef Bartunek, Marc Vanderheyden   +10 more
wiley   +1 more source

Community as Medicine: A Qualitative Exploration of Meaningful Social Support and Health for Trans‐ and Gender‐Diverse People in England

European Journal of Social Psychology, EarlyView.
ABSTRACT The poor mental and physical health of trans‐ and gender‐diverse (TGD) young people is well established and commonly attributed to gender minority stress. Although recent research has shown that social support can mitigate these effects, less attention has been paid to the psychological processes through which this occurs.
Chase Staras, Juliet Wakefield, Daragh McDermott, Bethany Jones   +3 more
wiley   +1 more source

Honesty in Difficult Conversations: Insights From Healthcare Professionals

European Journal of Social Psychology, EarlyView.
ABSTRACT When being honest is expected to cause emotional distress to those it concerns, it can be difficult to practice. This study examines how honesty is understood and accounted for in situations of emotional, moral and relational complexity. Drawing on semi‐structured interviews with 16 Danish healthcare professionals (8 doctors and 8 nurses), we ...
Anna Louise Z. Malfilâtre, Rachele Mazzini, Lau Lilleholt, Ingo Zettler, Séamus A. Power   +4 more
wiley   +1 more source

Cumulative electroconvulsive therapy sessions and focal epilepsy: A nationwide cohort study in Japan

Epilepsia Open, EarlyView.
Abstract Objective Electroconvulsive therapy (ECT) is widely used for severe psychiatric disorders, yet concerns remain regarding possible epileptogenic effects associated with prolonged or repeated exposure. We examined the association between cumulative ECT sessions and focal epilepsy in a nationwide Japanese cohort.
Masahiro Hata, Yuki Miyazaki, Hisaki Omori, Shun Takahashi, Manabu Ikeda   +4 more
wiley   +1 more source

‘They Should Understand That the Anorexia Drives me to do Anything’: Exploring How Individuals With Anorexia Nervosa Make Sense of the Experience of Medical Admissions

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a complex disorder associated with significant morbidity and mortality. Some people with AN require medical admissions to manage physical complications. Currently, little is known about how these medical admissions are experienced, despite an increase in the number of individuals being hospitalised.
Hannah Webb, Penny Neild, Vanessa Lawrence, Ulrike Schmidt, Maria Griffiths   +4 more
wiley   +1 more source