Results 31 to 40 of about 120,000 (268)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Patterns of immunotherapy-induced pneumonitis in patients with non-small-cell lung cancer: a case series

Journal of Medical Case Reports, 2021
Background Immunotherapy has become an efficacious option in the management of solid organ malignancies. Immune-related adverse events including pneumonitis are well described and may be particularly of concern in patients receiving immunotherapy for non-
Sarah Picard, Desiree Goh, Ashley Tan, Nisha Sikotra, Eli Gabbay, Tim Clay   +5 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

No evidence of mid-flexion instability after robotic-assisted total knee arthroplasty as assessed by intraoperative pressure sensors

Arthroplasty
Purpose Mid-flexion instability has been identified as a cause for dissatisfaction following total knee arthroplasty (TKA). Robotic-assisted surgery using the Mako robot only allows for assessment of stability at 10° and 90°.
Mateo Armendariz, Baha John Tadros, Dermot Collopy, Gavin Clark   +3 more
doaj   +1 more source

Exploring psychological experiences of soldiers who have undergone voluntary male medical circumcision at the Engineers Battalion in Kasungu, Malawi

Health SA Gesondheid: Journal of Interdisciplinary Health Sciences
Background: Voluntary medical male circumcision (VMMC) has gained recognition for its potential to reduce the risk of HIV transmission. However, limited academic research has comprehensively examined the psychological experiences of individuals who have ...
George Chapweteka, Nixon Chidzere, Thandie Munthali, Patson Kumwenda, Chimwemwe Munthali, Esmie Mkwinda, Geldine Chironda   +6 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Inferior vena cava filters (IVCFs): a review of uses and application to international guidelines at a single Australian center; implications of venous thromboembolism associated with malignancy

Pulmonary Circulation, 2018
Venous thromboembolism (VTE) is a potentially lethal event. Anticoagulation is the cornerstone of treatment. Inferior vena cava filters (IVCFs) may be used in circumstances when anticoagulation is contraindicated or as an adjunct to anticoagulation. IVCF
Philip Craven, Ciara Daly, Randall Oates, Nisha Sikotra, Tim Clay, Eli Gabbay   +5 more
doaj   +1 more source

‘God of Gods’

Indo-Iranian Journal
Abstract The Iranian flavour of the Chinese epithet of the Buddha, tianzhong tian 天中天, ‘god among gods,’ and its relationship with the Indo-Aryan parallel devātideva-, ‘foremost god of gods,’ have been repeatedly addressed. Past studies of the origin of the expressions sought to establish an ultimate connection to the Achaemenid royal title ‘king ...
Francesco Barchi, Benedikt Peschl
openaire   +1 more source

Disease Course After Anti‐CD20 Discontinuation in Secondary Progressive Multiple Sclerosis—A Multicenter Long‐Term Longitudinal Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe long‐term outcomes after anti‐CD20 discontinuation in selected patients with secondary progressive multiple sclerosis (SPMS) who remained without subsequent disease‐modifying therapy (DMT). Methods We retrospectively analyzed data from four centers in Austria and Switzerland.
Ferdinand Otto, Dariia Kliushnikova, Richard Friedrich Radlberger, Sinan Yasaroglu, Tobias Moser, Andrea Harrer, Kitty Kratzer, Wolfgang Hitzl, Christiane Gradl, Martin Schmidauer, Patrick Roth, Harald Hegen, Peter Wipfler   +12 more
wiley   +1 more source

Prevalence of anxiety and associated factors among guardians of children admitted with severe malaria at Thyolo District Hospital in Malawi

South African Journal of Psychiatry
Background: Anxiety is a common psychological response among caregivers of children with severe illnesses, yet limited research has explored its prevalence and associated factors in guardians of children with severe malaria in Malawi.
Nixon Chidzere, Chimwemwe Munthali, George Chapweteka, Thandie Munthali, Patson Kumwenda, Blessings Chikasema, Esmie Mkwinda, Geldine Chironda   +7 more
doaj   +1 more source