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Nodular Goiter and Thyroid Cancer
New England Journal of Medicine, 1948IN THE therapeutic attack on malignant tumors in general, the accumulated experience of generations has established as virtually axiomatic certain well defined principles. The first is the folly of attempting to arrive at a diagnosis by observation of the continued growth of a tumor or area of nodularity until its malignant nature is clear and ...
T J, ANGLEM, M L, BRADFORD
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THE EVOLUTION OF NODULAR GOITER
The Journal of Clinical Endocrinology & Metabolism, 1953SIMPLE goiter occurs sporadically all over the world and in the form of endemic goiter affects millions of people in every continent, as a recent World Health Organization conference1 so clearly showed. Simple goiter almost inevitably progresses to the nodular form, and thus a clear knowledge of how these nodules arise and what changes they may undergo
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Nontoxic Goiter - Diffuse or Nodular
Medical Clinics of North America, 1975Nontoxic goiters are very common. A single hyperfunctioning nodule is never malignant. Treatment is required only if the patient is hyperthyroid. Most single hypofunctioning thyroid nodules are cool and most are benign; however, it is important to rule out malignancy.
F, Maloof, C A, Wang, A L, Vickery
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The Evolution of Toxic Nodular Goiter
Archives of Internal Medicine, 1964In 1913 Plummer differentiated exophthalmic goiter from toxic adenomatous goiter on the basis of clinical observations on 2,000 operated cases.1He recognized that the former might be superimposed on any stage of endemic goiter, with resultant problems in differential diagnosis that might be difficult to resolve on either clinical or pathological ...
J M, MILLER, R C, HORN, M A, BLOCK
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The Nontoxic Nodular Hyperplastic Goiter
New England Journal of Medicine, 1955RECENT studies on sporadic goitrous cretinism1 2 3 4 5 have called attention to the interesting paradox of hypothyroidism associated with a hyperplastic nodular goiter. These studies have demonstrated an intrinsic defect within the thyroid gland in its synthesis of thyroid hormone that can occur at different stages, either in the binding of iodine to ...
G O, BELL, C H, EISENBEIS
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Nodular Goiter and Thyroid Cancer
New England Journal of Medicine, 1958THE practice of removing a nodule or multiple nodules from the thyroid gland for the prevention of cancer has been challenged in recent years. The justification for this procedure arose from the concept, held for many years, that a large proportion of thyroid cancers arose from a pre-existing adenoma or from multiple nodular goiters. Regardless of this
L M, HURXTHAL, A C, HEINEMAN
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Scintigraphic evaluation of nodular goiter
Seminars in Nuclear Medicine, 1971The thyroid scintiscan is primarily a function test, and it must be correlated with the anatomical findings for proper interpretation. Thyroid nodules are classified as nonfunctioning ("cold"), functioning ("warm"), and autonomous ("hot"), a division which facilitates proper management. Additional scintigraphic studies may be required in some cases for
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Dakar medical, 2009
To date no study in our country was specifically dedicated on toxic nodular goiter. They were just mentioned in generally studies about hyperthyroidism.The authors report a retrospective series of 62 cases of toxic nodular goitre collected between 1979 and 1999 at the internal medical clinic of Dakar teaching hospital.
Pamela R. Schroeder, Paul W. Ladenson
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To date no study in our country was specifically dedicated on toxic nodular goiter. They were just mentioned in generally studies about hyperthyroidism.The authors report a retrospective series of 62 cases of toxic nodular goitre collected between 1979 and 1999 at the internal medical clinic of Dakar teaching hospital.
Pamela R. Schroeder, Paul W. Ladenson
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Molecular pathogenesis of nodular goiter
Langenbeck's Archives of Surgery, 2011Familial clustering of goiters mostly with an autosomal dominant pattern of inheritance has repeatedly been reported. Moreover, other environmental and etiologic factors are likely to be involved in the development of euthyroid goiter. Therefore, a multifactorial etiology based on complex interactions of both genetic predisposition and the individuals'
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Carcinoma in Nodular Goiter of Childhood
Postgraduate Medicine, 1968From 1930 to 1960, Lahey Clinic physicians saw 79 children under 15 years of age with nodular goiter. Thirteen were referred with an established diagnosis of carcinoma, and nine of the 66 patients first seen at the Clinic also had carcinoma. In most cases, surgeons removed the lobe with the cancer, excised a generous portion of the opposite lobe and ...
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