Results 41 to 50 of about 509,047 (307)

Holographic microscopy for the three-dimensional exploration of light scattering from gold nanomarkers in biological media

, 2011
The 3D structure of light scattering from dark-field illuminated live 3T3 cells marked with 40 nm gold nanomarkers is explored. For this purpose, we use a high resolution holographic microscope combining the off-axis heterodyne geometry and the phase ...
Abboud, Marie, Desbiolles, Pierre, Gross, Michel, Joud, Fadwa, Verpillat, Frédéric   +4 more
core   +4 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Deep gold prospectivity modeling in the Jiaojia gold belt, Jiaodong Peninsula, eastern China using machine learning of geometric and geodynamic variables

Frontiers in Earth Science
Gold mineralization in the Jiaojia gold belt was formed in a structurally-dominant hydrothermal mineral system showing a close spatial association with the Jiaojia detachment fault.
Guanghuan Chen, Guanghuan Chen, Guanghuan Chen, Zhankun Liu, Zhankun Liu, Zhankun Liu, Guodong Chen, Guodong Chen, Guodong Chen, Shaofeng Xie, Xin Yang, Xiao Li, Yudong Chen, Yudong Chen, Zihe Hao, Zihe Hao, Huiting Zhong, Huiting Zhong, Liqun Jiang, Liqun Jiang   +19 more
doaj   +1 more source

Using Bacillus Cereus as a Geo-Biological Marker For Gold Prospecting in Iran [PDF]

International Journal of Mining and Geo-Engineering, 2012
Several methods have been developed for gold exploration in the past, among which biological base method is known to be the most efficient with least expenses. This method can also be used for latent gold prospects exploration.
B. Tokhmechi, M. Mamarabadi
doaj  

Deep exploration of Jiaodong type gold deposit, taking Shanhou gold deposit, southern part of Zhaoping fault as an example

Frontiers in Earth Science, 2022
Crustal response induced by the subduction of Paleo-Pacific Plate, is crucial to study the metallogenic law and prediction of Jiaodong type gold deposit. Gold deposits are preferentially hosted in the lithospheric-scale second-order faults, which provide
Zhi-He Xu, Zhi-He Xu, Zhi-He Xu, Zhi-He Xu, Zheng-Jiang Ding, Guan-Wen Gu, Guan-Wen Gu, Ji-Yi Jiang, Ji-Yi Jiang, Li Wang, Xing-Guo Niu   +10 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Exploration and scientific research of the Jiaojia-type gold deposit

Dizhi lixue xuebao
[Objective] Jiaojia-type gold deposit is a new type of gold mine discovered by Shandong geologists in northwestern Jiaodong in the 1960s, and its output is controlled by regional tectonic fracture zones.
ZHOU Mingling, SUN Liangliang, LYU Junyang, WANG Bin, LIU Xiangdong, BAO Zhongyi, ZHANG Qibin, ZHOU Xiaoping, XIE Tianci, WANG Shanshan, LIU Caijie, XU Shaohui, YAN Chunming, ZHANG Peng, ZHANG Liangliang, YANG Zhenliang, FAN Jiameng, ZHAO Chengle, GUO Meili, LI Ruixiang   +19 more
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source