Results 41 to 50 of about 54,082 (295)

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Current Status and Prospects of Mineral Sorting Technology Research at Home and Abroad [PDF]

E3S Web of Conferences
With the continuous exploitation of mining resources, the grade of selected ores gradually decreases, and the cost of crushing, grinding, and beneficiation gradually increases.
Qin Guanglin, Sun Lianxi, Liu Yunzhi, Zhang Xiaoguang, Jing Xiaolei, Ji Qiang   +5 more
doaj   +1 more source

Improving the Stability of Subsurface Structures in Deep Metal Mines by Stress and Energy Adjustment: A Case Study

Advances in Civil Engineering, 2021
In deep hard-rock mines, the failure of subsurface structures (e.g., tunnels, stopes, and shafts) has been a significant problem affecting mining safety due to the high-stress environment.
Huanxin Liu, Xingquan Liu, Zhuoying Tan, Yang Liu, Guilin Li   +4 more
doaj   +1 more source

Streptavidins Coordinate Biotin Sequestration and Self‐Resistance Within a Biotin‐Pathway Antibiotic Network

Advanced Science, EarlyView.
A conserved genomic region between two streptavidin genes in Streptomyces packages biosynthetic gene clusters for diverse biotin‐pathway antibiotics: acidomycin, stravidin, the new non‐proteinogenic amino acid ANDA, and the new BioA inhibitor α‐methyl‐KAPA.
Sumire Kurosawa, Jingjun Mo, Xiaotong Diao, Feng Xie, Tingting Wang, Haowen Zhao, Dalei Wu, Rolf Müller, Chengzhang Fu   +8 more
wiley   +1 more source

Harnessing Phase Separation for the Development of High‐Performance Hydrogels

Advanced Science, EarlyView.
ABSTRACT Hydrogels are indispensable for the development of next‐generation bioelectronics, soft robotics, and biomedical devices, where their mechanical properties determine performance and reliability. Among strategies to enhance hydrogel mechanics, phase separation enables controlled heterogeneity resulting in gel networks that are reinforced by ...
Yue Shao, Yiming Ma, Baihao Shao, Molly M. Stevens   +3 more
wiley   +1 more source

Diffusion‐Based Generative Model With Scaffold‐Hopping Strategy Yields Highly Potent Bioactive Molecules

Advanced Science, EarlyView.
SMarT‐Diff introduces a multi‐objective generative paradigm that integrates scaffold hopping with structure‐aware scoring to enable controlled exploration beyond the training distribution. The framework consistently balances drug‐likeness, synthesizes accessibility and bioactivity, yielding chemically diverse candidates with enhanced properties.
Yuwei Yang, Xiaoqing Gong, Shukai Gu, Jing Li, Bo Liu, Yanan Tian, Qianqian Zhang, Xiaojun Yao, Huanxiang Liu   +8 more
wiley   +1 more source

Geophysical data interpretation of the tectonic deformation lithofacies belts in the ore field: Application in ore prospecting

Dizhi lixue xuebao, 2021
Based on the physical parameters of the rocks (ores) and the genetic types of ore deposits, the geophysical exploration models have met issues of multiple solutions for deep prospecting prediction.
ZHANG Baolin, LYU Guxian, YU Jianguo, LIANG Guanghe, XU Xingwang, LI Zhiyuan, ZHANG Qipeng, SHI Xiaoming, WEI Junbin, XU Daoxue, LI Xu, ZHAO Peng   +11 more
doaj   +1 more source

Artisanal Gold Mining Camps in the Butana (Eastern Sudan) as Migration Hubs

, 2023
Artisanal and small-scale gold mining sites have become large-scale migration hubs for thousands of young men from Sudan and its neighbouring countries.
Abdul-Jalil, Musa Adam
core  

How Advanced Artificial Intelligence Technologies Shape Drug–Drug and Drug–Target Interaction Modeling

Advanced Science, EarlyView.
This review explores the convergence of artificial intelligence technologies in modeling drug–drug and drug–target interactions. By evaluating advanced feature engineering, architectural innovations, and learning paradigms reveals shared evolutionary trends and critical challenges, such as cold‐start settings and shortcut learning.
Xin Sun, Tong Wang
wiley   +1 more source

Lessons From Drug Discovery for Cryoprotective Agent Design: An AI‐Oriented Perspective

Advanced Science, EarlyView.
Cryoprotectant design is reframed through the lens of drug discovery as a multiparameter optimization problem. This perspective highlights how AI and systematic design strategies could enable safer, more effective cryoprotectants, while identifying key limitations that currently constrain predictive progress in cryobiology. ABSTRACT Cryopreservation is
Dominika Wilczok, Jesús Valdés‐Hernández, Varinia Bernales, Alán Aspuru‐Guzik, Alex Zhavoronkov   +4 more
wiley   +1 more source