A novel platform for isotype-specific testing of autoantibodies. [PDF]
, 2019 The objective of this study was to test if a novel platform could be used for isotype-specific autoantibody testing in humans. Further, we evaluated if testing with this novel platform enables earlier detection of insulin autoantibodies in individuals ...
Carter, Kaylene L +4 more
core +2 more sources
Gollum: A Gold Standard for Large Scale Multi Source Knowledge Graph Matching [PDF]
arXiv, 2022 The number of Knowledge Graphs (KGs) generated with automatic and manual approaches is constantly growing. For an integrated view and usage, an alignment between these KGs is necessary on the schema as well as instance level. While there are approaches that try to tackle this multi source knowledge graph matching problem, large gold standards are ...
arxiv
Rifampin Drug Resistance Tests for Tuberculosis: Challenging the Gold Standard [PDF]
Journal of Clinical Microbiology, 2013 ABSTRACT The rapid diagnosis of rifampin resistance is hampered by a reported insufficient specificity of molecular techniques for detection of rpoB mutations. Our objective for this study was to document the prevalence and prognostic value of rpoB mutations with unclear phenotypic ...
Bouke C. de Jong +10 more
openaire +2 more sources
PROVA DE TOLERÂNCIA A UMA REFEIÇÃO MISTA COMO MÉTODO DE RASTREIO DE DIABETES GESTACIONAL: UMA REVISÃO NARRATIVA [PDF]
, 2020 The oral glucose tolerance test is, to this day, the gold standard method to screen for gestational diabetes mellitus, even though it can cause various side effects.
Guarino, Maria Pedro +3 more
core +1 more source
Notes on Exact Power Calculations for t Tests and Analysis of Covariance [PDF]
Statistics in Biopharmaceutical Research 2020, 2020 Tang derived the exact power formulae for t tests and analysis of covariance (ANCOVA) in superiority, noninferiority and equivalence trials. The power calculation in equivalence trials can be simplified by using Owen's Q function, which is available in standard statistical software.
arxiv +1 more source
Unified Least Squares Methods for the Evaluation of Diagnostic Tests With the Gold Standard [PDF]
Cancer Informatics, 2017 The article proposes a unified least squares method to estimate the receiver operating characteristic (ROC) parameters for continuous and ordinal diagnostic tests, such as cancer biomarkers. The method is based on a linear model framework using the empirically estimated sensitivities and specificities as input “data.” It gives consistent estimates for
Liansheng Larry Tang +4 more
openaire +4 more sources
Monitoring functional capacity in heart failure. [PDF]
, 2019 This document reflects the key points of a consensus meeting of the Heart Failure Association of European Society of Cardiology (ESC) held to provide an overview the role of physiological monitoring in the complex multimorbid heart failure (HF) patient ...
Aaby +58 more
core +1 more source
Human papillomavirus testing as a cytology gold standard: comparing Surinam with the Netherlands [PDF]
Modern Pathology, 2005 Polymerase chain reaction to detect high-risk human papillomavirus has been suggested as a gold standard for cytology. The Netherlands and Surinam were prospectively compared in regard to the proportions of Negative, Atypical Squamous Cells of Undetermined Significance, and Squamous Intraepithelial Lesion smears that had detectable high-risk human ...
Mitchell S Wachtel +3 more
openaire +4 more sources
Evaluation of the Sensitivity and Specificity of three Rapid Test Kits Used in the Detection of Human Immunodeficiency Virus (Hiv) in Public Hospital Niger State, Nigeria [PDF]
, 2022 Purpose: The assessment of HIV rapid test kits commonly used was evaluated for optimum performance on the suspected patient. This study aims to determine the sensitivity and specificity of rapid test kits used in public hospitals in Minna, Niger State ...
Abdullahi, Muhammad +4 more
core +3 more sources
Multiple sclerosis clinical decision support system based on projection to reference datasets
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1863-1873, December 2022., 2022 Abstract Objective Multiple sclerosis (MS) is a multifactorial disease with increasingly complicated management. Our objective is to use on‐demand computational power to address the challenges of dynamically managing MS. Methods A phase 3 clinical trial data (NCT00906399) were used to contextualize the medication efficacy of peg‐interferon beta‐1a vs ...
Chadia Ed‐driouch +13 more
wiley +1 more source