Results 61 to 70 of about 3,076,378 (375)
When More Is Less: Pitfalls of significance testing [PDF]
arXiv, 2022 The controversy about statistical significance vs. scientific relevance is more than 100 years old. But still nowadays null hypothesis significance testing is considered as gold standard in many empirical fields from economics and social sciences over psychology to medicine, and small $p$-values are often the key to publish in journals of high ...
arxiv
Clinical utility of cerebrospinal fluid biomarkers measured by LUMIPULSE® system
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1898-1909, December 2022., 2022 Abstract Objectives Cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are well‐established in research settings, but their use in routine clinical practice remains a largely unexploited potential. Here, we examined the relationship between CSF biomarkers, measured by a fully automated immunoassay platform, and brain β‐amyloid (Aβ ...
Hisashi Nojima +9 more
wiley +1 more source
Evaluation of diagnostic tests when there is no gold standard. A review of methods
Health Technology Assessment, 2007 To generate a classification of methods to evaluate medical tests when there is no gold standard.Multiple search strategies were employed to obtain an overview of the different methods described in the literature, including searches of electronic databases, contacting experts for papers in personal archives, exploring databases from previous ...
Anne W S Rutjes +4 more
openaire +4 more sources
Establishing a Gold Standard for Test Sets [PDF]
Academic Radiology, 2013 Test sets for assessing and improving radiologic image interpretation have been used for decades and typically evaluate performance relative to gold-standard interpretations by experts. To assess test sets for screening mammography, a gold-standard for whether a woman should be recalled for additional work-up is needed, given that interval cancers may ...
Lawrence W. Bassett +13 more
openaire +4 more sources
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2013 The test-negative design (TND) is an efficient form of case-control study commonly applied to influenza vaccine effectiveness (VE) estimation. TND validity is predicated on the core assumption that the intervention (vaccine) has no effect on other non ...
G. Serres +3 more
semanticscholar +1 more source
The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022 Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee +16 more
wiley +1 more source
Semiparametric Estimation of the Covariate-Specific ROC Curve in Presence of Ignorable Verification Bias [PDF]
, 2011 Covariate-specific ROC curves are often used to evaluate the classification accuracy of a medical diagnostic test or a biomarker, when the accuracy of the test is associated with certain covariates. In many large-scale screening tests, the gold standard
Liu, Danping, Zhou, Xiao-Hua
core +2 more sources
Development of Gold Contacted Flip-chip Detectors with IMARAD CZT [PDF]
, 2000 We present initial results from our evaluation of a gold-contacted pixellated detector using cadmium zinc telluride substrate produced by IMARAD Imaging Systems. The Horizontal Bridgman (HB) grown crystals from IMARAD have been shown to produce high resolution photopeaks, but they are also seen to have large leakage current.
arxiv +1 more source
How many labelers do you have? A closer look at gold-standard labels [PDF]
arXiv, 2022 The construction of most supervised learning datasets revolves around collecting multiple labels for each instance, then aggregating the labels to form a type of "gold-standard". We question the wisdom of this pipeline by developing a (stylized) theoretical model of this process and analyzing its statistical consequences, showing how access to non ...
arxiv
FEBS Letters, EarlyView.Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma +8 more
wiley +1 more source