Results 61 to 70 of about 2,932,343 (371)
Validating a novel web-based method to capture disease progression outcomes in multiple sclerosis [PDF]
, 2013 The Expanded Disability Status Scale (EDSS) is the current ‘gold standard’ for monitoring disease severity in multiple sclerosis (MS). The EDSS is a physician-based assessment.
Dobson, Ruth +4 more
core +1 more source
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
Evaluating Uncertainty in Dengue Seroprevalence in the Absence of a Gold Standard Diagnostic Test
McGill Journal of Medicine, 2020 Background: Shortly after the introduction of the first licensed vaccine against dengue fever (Dengvaxia), a serious outcome was attributed to the vaccine: vaccinated individuals without a previous dengue infection were at increased risk of developing ...
Tess Baker, David B. Wolfson
doaj
Clinical Liver Disease, 2019 Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in Western countries, affecting nearly 25% to 30% of the general population.
Daniel Berger, V. Desai, Sujit Janardhan
semanticscholar +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Assessment of the Gold Standard Test for Fetal Malnutrition Using Statistical and Boolean Analyses
Pakistan Journal of Medicine and DentistryBackground: Fetal malnutrition (FM), defined by inadequate fat and muscle deposition in utero, poses serious risks to neonatal and long-term health. Early identification is vital for prompt intervention.
Irum Javed +5 more
doaj +1 more source
International Journal of Dentistry, 2021 Aim of the Work. The goal of the current study was to investigate the capability of the cold test to predict the profound pulpal anesthesia before starting the endodontic treatment of mandibular first molars with symptomatic irreversible pulpitis (SIP ...
Mohamed El Sayed, Kamis Gaballah
doaj +1 more source
The Surgery Journal, 2022 Background Necrotizing fasciitis (NF) is a life-threatening condition requiring urgent attention. It is clinically difficult to diagnose, linked to severe systemic toxicity, and has poor prognosis.
Farah Naaz Kazi +4 more
doaj +1 more source
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2013 The test-negative design (TND) is an efficient form of case-control study commonly applied to influenza vaccine effectiveness (VE) estimation. TND validity is predicated on the core assumption that the intervention (vaccine) has no effect on other non ...
G. Serres +3 more
semanticscholar +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source