Results 141 to 150 of about 2,557 (278)

Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl‐tRNA Synthetase Boosts Genetic Code Expansion in E. coli

Advanced Science, EarlyView.
ABSTRACT Orthogonal translation systems (OTSs) enable site‐specific incorporation of non‐canonical amino acids (ncAAs) and are central to genetic code expansion. Current engineering strategies typically rely on hyperstable aminoacyl tRNA synthetase (aaRS) scaffolds to tolerate destabilizing mutations required for substrate diversification.
Nikolaj G. Koch, Peter Goettig, Michael A. Nash, Juri Rappsilber, Nediljko Budisa   +4 more
wiley   +1 more source

THE GOLDEN HORDE AND THE PENZA REGION

Археология евразийских степей
After the Mongol invasion, the few remaining monuments of the Upper Posurye and Moksha region became part of the Golden Horde, and the population of this region, preserving old traditions, gradually began to play an important role in the life of the new state. Archaeological studies of the monuments of this period (primarily the Narovchatsky settlement
Gennady N. Belorybkin, Tatyana V. Osipova   +1 more
openaire   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

North Pontic crossroads: Mobility in Ukraine from the Bronze Age to the early modern period [PDF]

Sci Adv
Saag L, Utevska O, Zadnikov S, Shramko I, Gorbenko K, Bandrivskyi M, Pavliv D, Bruyako I, Grechko D, Okatenko V, Toshev G, Andrukh S, Radziyevska V, Buynov Y, Kotenko V, Smyrnov O, Petrauskas O, Magomedov B, Didenko S, Heiko A, Reida R, Sapiehin S, Aksonov V, Laptiev O, Terskyi S, Skorokhod V, Zhyhola V, Sytyi Y, Järve M, Scheib CL, Anastasiadou K, Kelly M, Williams M, Silva M, Barrington C, Gilardet A, Macleod R, Skoglund P, Thomas MG.   +38 more
europepmc   +2 more sources

Genetic polymorphism of Y-chromosome in Kazakh populations from Southern Kazakhstan. [PDF]

BMC Genomics, 2023
Ashirbekov Y, Seidualy M, Abaildayev A, Maxutova A, Zhunussova A, Akilzhanova A, Sharipov K, Sabitov Z, Zhabagin M.   +8 more
europepmc   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Canagliflozin Alleviates Diabetic Glomerular Endothelial Injury via Melibiose in a Microbiota‐Dependent Manner

Advanced Science, EarlyView.
Canagliflozin treatment reshapes the gut microbiota in DKD and elevates levels of melibiose, a metabolite derived from Roseburia intestinalis. Melibiose directly binds to and enhances the enzymatic activity of glyoxalase 1, leading to decreased methylglyoxal accumulation.
Wei Zhang, Yi Song, Changkun Li, Yuanyuan Luo, Mingwei Shao, Feng Guo, Fangyi Wei, Xunjie Fan, Wenwen Guo, Fengmei Xu, Yanhong Sang, Dongming Zhang, Yanhong Zhou, Lianwei Wang, Zhiqiang Kang, Yingjun Yang, Chunhua Song, Yanxia Liu, Xiaojun Ma, Jiao Wang, Chong Li, Shengnan Ma, Lin Zhao, Zhi Qin, Guolan Xing, Qiubo Zhao, Jun Li, Shumin Song, Dan Zhao, Ting Huang, Qingzhu Wang, Yanyan Zhao, Guijun Qin   +32 more
wiley   +1 more source

Metagenomic Insights into the Taxonomic and Functional Features of Traditional Fermented Milk Products from Russia. [PDF]

Microorganisms, 2023
Elcheninov AG, Zayulina KS, Klyukina AA, Kremneva MK, Kublanov IV, Kochetkova TV.   +5 more
europepmc   +1 more source

The Reflection of the Golden Horde-Russian Struggle to Literature: The Epic of Zadonsina

, 2020
The Mongols that began to dominate the Russian lands from the first quarter of the 13th century, were increasingly stronger from the second half of that century and thus leading the establishment of the Golden Horde state, including various Turkic tribes.
Yucel, Mualla Uydu, Saginayeva, Ainagul
core  

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source