Results 51 to 60 of about 1,663,340 (263)

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan   +3 more
wiley   +1 more source

Evaluation of the golden proportion and golden standard of maxillary anterior teeth in relation to smile attractiveness

open access: yesBrazilian Dental Science, 2019
Objective: The present study aimed to explore the existence of golden proportion (GP) between the widths of maxillary anterior teeth and golden standard (GS) for width to height ratio of maxillary central incisor in individuals with attractive and non ...
Marwan Ahmed Swileh   +2 more
semanticscholar   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Nature-aligned approaches to form students’ system motivation

open access: yesОткрытое образование (Москва), 2017
Sustainable development of the society involves the transition of the society from the current evolutional stage to a higher stage without revolutionary destruction of the existing frames of society.
Marina V. Ulyanova
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Golden Proportion and Golden Standard Assessment of Maxillary Anterior Teeth Among Undergraduate Students

open access: yesJournal of The Pakistan Dental Association, 2019
ental esthetics is a prime consideration for all patients. The size and shape of the maxillary anterior teeth have significant affect not only on the dental esthetics, but also on the overall facial esthetics of a person.1 A mismatch between size and ...
Danish Shahnawaz   +5 more
semanticscholar   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

The Golden Proportion in Dentistry: A Literature Review

open access: yesMiddle East Journal of Rehabilitation and Health, 2016
Context: In the last 2 decades, several studies have questioned the application of the rule of the golden proportion in dentistry. Therefore, the purpose of this review study was to assess the dental use of the golden proportion. Evidence Acquisition: We performed MEDLINE and Cochrane searches for English language literature published through 2015 ...
Amir Ali Karamifar   +6 more
openaire   +1 more source

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