Results 101 to 110 of about 242,279 (275)
Deep Contrastive Learning for High‐Throughput Prediction of Drug Resistance Mutations from Sequences
Advanced Science, EarlyView.This study presents DeepMutDTA, a deep learning framework aimed at predicting mutation‐induced changes in protein‐drug interactions and prioritizing variants potentially linked to drug resistance. Trained on large‐scale data, it incorporates SimSiam‐MuTF, a label‐aware contrastive fine‐tuning strategy that encourages separation between WT and MT ...
Xiaowen Hu +7 more
wiley +1 more source
T-cell lymphoma infiltrating the uterus and ovaries of a Golden Retriever: a case report. [PDF]
Ir Vet J, 2023 Jo J +9 more
europepmc +1 more source
SISTEM PAKAR DIAGNOSA PENYAKIT ANJING GOLDEN RETRIEVER MENGGUNAKAN TEOREMA BAYES [PDF]
Golden Retriever merupakan ras anjing yang populer dan rentan terhadap berbagai penyakit. Permasalahan muncul ketika pemilik tidak memahami gejala awal penyakit dan sulitnya akses ke dokter hewan secara langsung.
Louis Fernando Sinaga +1 more
core +1 more source
Advanced Science, EarlyView.This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao +7 more
wiley +1 more source
Veterinary SciencesThe World Health Organization (WHO) recognizes the impact of social determinants of health (SDHs) on human health and wellbeing factors. Limited research has explored how SDHs, such as the social, economic, and environmental conditions in which ...
Elpida Artemiou +2 more
doaj +1 more source
Neural Fields for Highly Accelerated 2D Cine Phase Contrast MRI
Advanced Science, EarlyView.ABSTRACT 2D cine phase contrast (CPC) MRI provides quantitative information on blood velocity and flow within the human vasculature. However, data acquisition is time‐consuming, motivating the reconstruction of the velocity field from undersampled measurements to reduce scan times. In this work, neural fields are proposed as a continuous spatiotemporal
Pablo Arratia +7 more
wiley +1 more source
Multiple intra-abdominal fungal granulomas caused by Scedosporium apiospermum effectively treated with voriconazole in a Golden Retriever. [PDF]
Med Mycol Case Rep, 2023 Yoshimura A +5 more
europepmc +1 more source
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source
Charting Endocrine Progenitors Across Species and Organs
Advanced Science, EarlyView.Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing +21 more
wiley +1 more source
Mutations associated with progressive retinal atrophy in Golden Retriever dogs in Brazil
, 2022 A atrofia progressiva da retina (PRA) é uma enfermidade caracterizada por degeneração das células do tecido da retina, de evolução lenta e cuja sua etiologia no golden retriever envolve mutações em três genes diferentes descritos, prcd-PRA, SLC4A3 e TTC8
Trecenti-Santana, Anelize de Souza
core