Results 131 to 140 of about 23,329 (282)

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

Epidemiology of Cranial Cruciate Ligament Disease Diagnosis in Dogs Attending Primary-Care Veterinary Practices in England [PDF]

, 2015
Adams, Adams, Aragon, Au, Barnes, Bartlett, Bateson, Bennett, Bergh, Buote, Comerford, Conzemius, Dohoo, Duval, Egenvall, Fleming, Glas, Griffon, Guthrie, Harasen, Hayashi, Hohn, Hosmer, Irion, Johnson, Kearsley-Fleet, Kirkwood, McGreevy, Nelson, O'Neill, Off, Roberts, Slauterbeck, Strande, Vasseur, Vasseur, Watson, Whitehair, Witsberger   +38 more
core   +2 more sources

Nicotinamide and Pyridoxine Supplementation Enhances Muscle Stem Cell Activity and Muscle Regeneration in Humans: A Randomized Placebo‐Controlled Clinical Trial of High Force Eccentric Contraction Recovery in Healthy Young Men

Advanced Science, EarlyView.
In a randomized clinical trial, we test the potential of combined nicotinamide (NAM) and pyridoxine (PN) to improve muscle recovery through muscle stem cell (MuSC) activity. Daily oral NAM and PN supplementation after high intensity muscle contractions enhances MuSC activation and differentiation, and accelerates muscle regeneration, providing new ...
Grith Højfeldt, Joris Michaud, Ann Damgaard, Karoline Karlog, Eugenia Migliavacca, Sonia Karaz, Elham Pazirandeh‐Micol, Odd E. Johansen, Leonidas G. Karagounis, Bjørk W. Helge, William Hagemann, Michael Kjaer, Jerome N. Feige, Pascal Stuelsatz, Abigail L. Mackey   +14 more
wiley   +1 more source

Proton FLASH Exposure Preserves Gut Commensal Microbiomes and Spares Intestinal Stem Cells

Advanced Science, EarlyView.
This study highlights the role of Proton FLASH abdominal irradiation in sparing of intestinal stem cells and preservation of key gut microbial population resulting minimization of radiation toxicity in intestinal epithelium in mice. Our findings support the potential of Proton FLASH to improve the therapeutic ratio for abdominal radiation exposure ...
Rishi Man Chugh, Payel Bhanja, Emily Schueddig, Jufri Setianegara, Yuting Lin, Kenny Guida, Shujah Rehman, Stacey Krepel, Devin Koestler, Ronald C. Chen, Katherine L. Cook, Subhrajit Saha   +11 more
wiley   +1 more source

Retrobulbar embryonal tumor with multilayered rosettes in a golden retriever dog. [PDF]

Clin Case Rep, 2021
Martins BC, Struthers J, Abbott JR, Plummer CE.   +3 more
europepmc   +1 more source

Neural Fields for Highly Accelerated 2D Cine Phase Contrast MRI

Advanced Science, EarlyView.
ABSTRACT 2D cine phase contrast (CPC) MRI provides quantitative information on blood velocity and flow within the human vasculature. However, data acquisition is time‐consuming, motivating the reconstruction of the velocity field from undersampled measurements to reduce scan times. In this work, neural fields are proposed as a continuous spatiotemporal
Pablo Arratia, Martin J. Graves, Mary McLean, Carolin Pirkl, Carola‐Bibiane Schönlieb, Timo Schirmer, Florian Wiesinger, Matthias J. Ehrhardt   +7 more
wiley   +1 more source

Case report of canine discoid lupus erythematosus in Guatemala

Veterinary Medicine and Science
An 11‐year‐old male Golden Retriever was presented for consultation due to a chronic progressive lesion on the nose that had started a year before. The majority of the nasal mucosa was affected, with the disruption of the normal architecture, pigment ...
Estefany De León‐Robles, Mariana Colmenares, Gylari Mhelanya Calderón   +2 more
doaj   +1 more source

The Golden Retriever Lifetime Study: Assessing factors associated with owner compliance after the first year of enrollment. [PDF]

J Vet Intern Med, 2021
Ruple A, Jones M, Simpson M, Page R.
europepmc   +1 more source

Learnable Diffusion Framework for Mouse V1 Neural Decoding

Advanced Science, EarlyView.
We introduce Sensorium‐Viz, a diffusion‐based framework for reconstructing high‐fidelity visual stimuli from mouse primary visual cortex activity. By integrating a novel spatial embedding module with a Diffusion Transformer (DiT) and a synthetic‐response augmentation strategy, our model outperforms state‐of‐the‐art fMRI‐based baselines, enabling robust
Kaiwen Deng, Peter S. Schwendeman, Yuanfang Guan   +2 more
wiley   +1 more source

Preliminary Analysis of Intestinal Microbiota in Golden Retrievers Prone to Dilated Cardiomyopathy Due to Taurine Deficiency

Veterinary Sciences
Taurine plays a key role in cardiovascular and gastrointestinal health in dogs and may be deficient in some predisposed breeds despite consuming complete petfood.
Matilda Rachele Dametti, Mara Bagardi, Sara Ghilardi, Giulietta Minozzi, Michele Polli, Paola Giuseppina Brambilla, Eleonora Fusi   +6 more
doaj   +1 more source