Results 71 to 80 of about 67,800 (303)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Estimasi Parameter dan Dalam Pemulusan Eksponensial Ganda Dua Parameter Dengan Metode Modifikasi Golden Section [PDF]

open access: yes, 2012
Ada beberapa parameter yang harus dievaluasi pada metode pemulusn eksponensial sehingga didapatkan parameter optimal yang memberikan ukuran kesalahan peramalan terkecil.
Wahyuningsih, Nuri; Institut Teknologi Sepuluh Nopember (ITS)   +1 more
core   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Performance of Turbo-Codes with Some Proposed Interleaver Schemes

open access: yesAl-Khawarizmi Engineering Journal, 2017
This paper describes a number of new interleaving strategies based on the golden section. The new interleavers are called golden relative prime interleavers, golden interleavers, and dithered golden interleavers. The latter two approaches involve sorting
Ahmed S. Hadi
doaj  

La passion de la connaissance et l’esthétique des proportions chez Matyla Ghyka [PDF]

open access: yesJournal of Humanistic and Social Studies, 2016
Matyla Ghyka can be included in the series of writers saved by exile, a series including, among others, Mircea Eliade, Emil Cioran and Eugène Ionesco. Lesser-known in Romania, in comparison to the aforementioned writers, he lived a life extremely rich in
Radu Ciobotea
doaj  

The Golden Section and Attitudes Towards Mental Illness: How does Stigma Influence Golden Section Ratings? [PDF]

open access: yes, 2010
Studies have shown that when people are asked to make judgments about others using a list of bipolar adjective pairs, they consistently produce ratings that are approximately 62% positive and 38% negative.
Harasym, Melanie T.
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

open access: yesFEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová   +2 more
wiley   +1 more source

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