Results 41 to 50 of about 6,024 (176)
British Journal of Clinical Pharmacology, EarlyView.ABSTRACT Aims Imatinib improves hemodynamics in pulmonary arterial hypertension (PAH), but dose‐dependent toxicity has limited its clinical development. We aimed to quantify the dose–efficacy–toxicity relationship and evaluate alternative dosing strategies using data from the PIPAH trial.
Medhat M. Said +13 more
wiley +1 more source
The Extended Gompertz Distribution: Properties and Application Abstract
Maǧallaẗ Al-Buḥūṯ Al-TiǧāriyyaẗThe Extended Gompertz Distribution: Properties and Application Abstract This paper introduces the Marshall–Olkin Weibull–Gompertz (MOWGo) distribution, a new four-parameter extension of the classical Gompertz distribution.
زينب اسماعيل عطيه +2 more
doaj +1 more source
THE TRANSMUTED GAMMA-GOMPERTZ DISTRIBUTION
International Journal of Research -GRANTHAALAYAH, 2020 This article introduces a four-parameter probability model which represents a gener- alization of the the Gamma-Gompertz distribution using the quadratic rank trans- mutation map. The proposed model is named the Transmuted Gamma-Gompertz distribution. We provide explicit expressions for its statistical properties, moment generating function, quantile ...
Rwabi AzZwideen, Loai M. Al Zou’bi
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Mechanistic Digital Model for Real‐Time Monitoring and Optimization of Adenovirus Production
Biotechnology and Bioengineering, EarlyView.ABSTRACT Adenoviral vectors are a critical vaccine platform, with billions of vaccine doses administered during the COVID‐19 pandemic. In addition, they are promising therapeutics for cancer treatment. To advance their manufacturing, real‐time monitoring of adenovirus production is essential for process optimization, yield improvement, and product ...
Xingge Xu +4 more
wiley +1 more source
The Modified Beta Gompertz Distribution: Theory and Applications
Mathematics, 2018 In this paper, we introduce a new continuous probability distribution with five parameters called the modified beta Gompertz distribution. It is derived from the modified beta generator proposed by Nadarajah, Teimouri and Shih (2014) and the Gompertz ...
Ibrahim Elbatal +4 more
doaj +1 more source
A Hybrid Mechanistic Model Capturing Lactate Run‐Away and Back‐Metabolism in Mammalian Cell Culture
Biotechnology and Bioengineering, EarlyView.ABSTRACT Mechanistic modeling is important in biopharmaceutical manufacturing by enabling in‐silico experimentation. However, developing a robust mechanistic model for mammalian cell culture remains challenging due to the complexity of the underlying bioprocesses.
Li Qin +4 more
wiley +1 more source
Catheterization and Cardiovascular Interventions, EarlyView.ABSTRACT Background Rotational atherectomy (RA) has undergone considerable technical modernization in recent years. This study evaluated whether RA performed in the contemporary era was associated with superior cardiovascular outcomes compared with the traditional era. Aims To compare the clinical characteristics and cardiovascular outcomes of patients
Ravi Vazirani +15 more
wiley +1 more source
Axioms, 2023 In reliability and survival analysis, the time-to-failure data play an important role in the development of the reliability and life characteristics of the products. In some cases, these kinds of data are modeled using a competing risks model.
Laila A. Al-Essa +3 more
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Some characterizations of the exponentiated Gompertz distribution [PDF]
International Mathematical Forum, 2014 In this article, we discuss some characterizations of the exponentiated Gompertz distribution. The moments, quantiles, mode, mean residual lifetime, mean deviations and Renyi entropy have been obtained. In addition, we introduce the density, survival and hazard functions and determine the important result about the curve of the distribution and nature ...
Hanaa H. Abu-Zinadah, Anhar S. Aloufi
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[0,1] Truncated Exponential Marshall-Olkin-Gompertz Distribution: Properties and Applications
Tikrit Journal of Administrative and Economic Sciences, 2020 In this paper, a new compound distribution termed as [0,1]Truncated Exponential Marshall-Olkin-Gompertz (TEMO-Go)is introduced. Several essential statistical properties of TEMO-Go distribution were studied.
Alaa Abdulrahman Khalaf +1 more
doaj +1 more source